169 Publications (Page 1 of 7)
2019
NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers
Motea, Edward AMotea, Edward AMotea, Edward AHuang, XiumeiHuang, XiumeiHuang, XiumeiSingh, NaveenSingh, NaveenSingh, NaveenKilgore, Jessica AKilgore, Jessica AKilgore, Jessica AWilliams, Noelle SWilliams, Noelle SWilliams, Noelle SXie, Xian-JinXie, Xian-JinXie, Xian-JinGerber, David EGerber, David EGerber, David EBeg, Muhammad SBeg, Muhammad SBeg, Muhammad SBey, Erik ABey, Erik ABey, Erik ABoothman, David ABoothman, David A and Boothman, David A
Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 25, (no. 8), pp. 2609, 2019-Apr-15. | Journal Article
 
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
Li, XiaoguangLi, XiaoguangLiu, ZhidaLiu, ZhidaZhang, AnliZhang, AnliHan, ChuanhuiHan, ChuanhuiShen, AijunShen, AijunJiang, LingxiangJiang, LingxiangBoothman, David ABoothman, David AQiao, JianQiao, JianWang, YangWang, YangHuang, XiumeiHuang, XiumeiFu, Yang-Xin and Fu, Yang-Xin
Nature communications, vol. 10, (no. 1), pp. 13, 2019-Jul-19. | Journal Article
 
Targeting NAD.sup.+ Metabolism to Enhance Radiation Therapy Responses
Lewis, Joshua ELewis, JoshuaSingh, NaveenSingh, NaveenHolmila, Reetta JHolmila, ReettaSumer, BaranSumer, Baran DWilliams, Noelle SWilliams, NoelleFurdui, CristinaFurdui, Cristina MKemp, MelissaKemp, Melissa LBoothman, David A and Boothman, David
Seminars in Radiation Oncology, vol. 29, (no. 1), pp. 6, 20190101. | Journal Article
2018
Following anticancer drug activity in cell lysates with DNA devices
Kahanda, DimithreeKahanda, D.Singh, N.Singh, NaveenBoothman, D. A.Boothman, David ASlinker, Jason D and Slinker, J. D.
Biosensors and Bioelectronics, vol. 119, pp. 9, 2018-11-15. | Journal Article
 
Genome-scale metabolic modeling identifies novel targets of redox metabolism in radiation-resistant tumors
Lewis, JoshuaFurdui, CristinaBoothman, David and Kemp, Melissa
Free Radical Biology and Medicine, vol. 128, pp. S88, 2018-11-00. | Journal Article
 
Genome-Scale Modeling of NADPH-Driven β-Lapachone Sensitization in Head and Neck Squamous Cell Carcinoma
Lewis, Joshua ELewis, Joshua ECostantini, FrancescoCostantini, FrancescoMims, JadeMims, JadeChen, XiaofeiChen, XiaofeiFurdui, Cristina MFurdui, Cristina MBoothman, David ABoothman, David AKemp, Melissa L and Kemp, Melissa L
Antioxidants & Redox Signaling, vol. 29, (no. 10), pp. 952, 2018-10-01. | Journal Article
 
Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers
Motea, Edward AMotea, Edward AMotea, Edward AFattah, Farjana JFattah, Farjana JFattah, Farjana JXiao, LingXiao, LingXiao, LingGirard, LucGirard, LucGirard, LucRommel, AmyRommel, AmyRommel, AmyMorales, Julio CMorales, Julio CMorales, Julio CPatidar, PraveenPatidar, PraveenPatidar, PraveenZhou, YunyunZhou, YunyunZhou, YunyunPorter, AndrewPorter, AndrewPorter, AndrewXie, YangXie, YangXie, YangMinna, John DMinna, John DMinna, John DBoothman, David ABoothman, David A and Boothman, David A
Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 24, (no. 24), pp. 6470, 2018-Dec-15. | Journal Article
 
Modulators of Redox Metabolism in Head and Neck Cancer
Chen, XiaofeiChen, XiaofeiChen, XiaofeiChen, XiaofeiChen, XiaofeiChen, XiaofeiChen, XiaofeiMims, JadeMims, JadeMims, JadeMims, JadeMims, JadeMims, JadeMims, JadeHuang, XiumeiHuang, XiumeiHuang, XiumeiHuang, XiumeiHuang, XiumeiHuang, XiumeiHuang, XiumeiSingh, NaveenSingh, NaveenSingh, NaveenSingh, NaveenSingh, NaveenSingh, NaveenSingh, NaveenMotea, EdwardMotea, EdwardMotea, EdwardMotea, EdwardMotea, EdwardMotea, EdwardMotea, EdwardPlanchon, Sarah MPlanchon, Sarah MPlanchon, Sarah MPlanchon, Sarah MPlanchon, Sarah MPlanchon, Sarah MPlanchon, Sarah MBeg, MuhammadBeg, MuhammadBeg, MuhammadBeg, MuhammadBeg, MuhammadBeg, MuhammadBeg, MuhammadTsang, Allen WTsang, Allen WTsang, Allen WTsang, Allen WTsang, Allen WTsang, Allen WTsang, Allen WPorosnicu, MercedesPorosnicu, MercedesPorosnicu, MercedesPorosnicu, MercedesPorosnicu, MercedesPorosnicu, MercedesPorosnicu, MercedesKemp, Melissa LKemp, Melissa LKemp, Melissa LKemp, Melissa LKemp, Melissa LKemp, Melissa LKemp, Melissa LBoothman, David ABoothman, David ABoothman, David ABoothman, David ABoothman, David ABoothman, David ABoothman, David AFurdui, Cristina MFurdui, Cristina MFurdui, Cristina MFurdui, Cristina MFurdui, Cristina MFurdui, Cristina M and Furdui, Cristina M
Antioxidants & Redox Signaling, vol. 29, (no. 16), pp. 1690, 2018-12-01. | Journal Article
 
Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis
Gerber, David EGerber, David EBeg, M ShaalanBeg, M ShaalanFattah, FarjanaFattah, FarjanaFrankel, Arthur EFrankel, Arthur EFatunde, OluwatomiladeFatunde, OluwatomiladeArriaga, YullArriaga, YullDowell, Jonathan EDowell, Jonathan EBisen, AjitBisen, AjitLeff, Richard DLeff, Richard DMeek, Claudia CMeek, Claudia CPutnam, William CPutnam, William CKallem, Raja ReddyKallem, Raja ReddySubramaniyan, IndhumathySubramaniyan, IndhumathyDong, YingDong, YingBolluyt, JoyceBolluyt, JoyceSarode, VenetiaSarode, VenetiaLuo, XinLuo, XinXie, YangXie, YangSchwartz, BrianSchwartz, BrianBoothman, David A and Boothman, David A
British journal of cancer, vol. 119, (no. 8), pp. 936, 2018-Oct. | Journal Article
2017
Phase 1 study of ARQ 761, a β-lapachone analog that promotes NQO1-mediated programmed cancer cell necrosis
Gerber, David EBisen, Ajit KumarBeg, Muhammad ShaalanFrankel, Arthur EFatunde, OluwatomiladeFattah, FarjanaArriaga, Yull EdwinDowell, JonathanMeek, ClaudiaBolluyt, Joyce DSarode, VenetiaLuo, XinXie, YangSchwartz, Brian EBoothman, David A and Leff, Richard
Journal of Clinical Oncology, vol. 35, (no. 15_suppl), pp. 2517, 2017-05-20. | Journal Article
 
The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism
Silvers, Molly AMA, SilversS, DejaDeja, StanislawN, SinghSingh, NaveenEgnatchik, Robert ARA, EgnatchikSudderth, JessicaJ, SudderthLuo, XiuquanX, LuoMS, BegBeg, Muhammad SBurgess, Shawn CSC, BurgessDeBerardinis, Ralph JRJ, DeBerardinisDA, BoothmanBoothman, David AMerritt, Matthew E and Me, Merritt
The Journal of biological chemistry, vol. 292, (no. 44), pp. 18216, 2017-11-03. | Journal Article
 
Using a novel NQO1 bioactivatable drug, beta‐lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer
MS, BegBeg, Muhammad ShaalanBeg, Muhammad ShaalanHuang, XiumeiX, HuangHuang, XiumeiMA, SilversSilvers, Molly ASilvers, Molly AGerber, David EDE, GerberGerber, David EBolluyt, JoyceBolluyt, JoyceJ, BolluytV, SarodeSarode, VenetiaSarode, VenetiaFattah, FarjanaFattah, FarjanaF, FattahDeberardinis, Ralph JDeberardinis, Ralph JRJ, DeberardinisMe, MerrittMerritt, Matthew EMerritt, Matthew EXie, Xian‐JinXJ, XieXie, Xian‐JinLeff, RichardLeff, RichardR, LeffLaheru, DanielLaheru, DanielD, LaheruDA, BoothmanBoothman, David A and Boothman, David A
Journal of Surgical Oncology, vol. 116, (no. 1), pp. 88, July 1, 2017. | Journal Article
2016
Abstract 5093: Fibulin-5 supports pancreatic tumor growth through inhibition of integrin-induced ROS
Topalovski, MaryWang, MiaoMoore, ZacharyBoothman, David and Brekken, Rolf
Cancer Research, vol. 76, (no. 14 Supplement), pp. 5093, 2016-07-15. | Journal Article
 
Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors
Yan, YunfengZhou, KejinXiong, HuMiller, JasonMotea, EdwardBoothman, DavidLiu, Li and Siegwart, Daniel
Biomaterials, vol. 118, pp. 93, 2016. | Journal Article
 
Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer
Tang, Ke-JingTang, Ke-JingTang, Ke-JingConstanzo, Jerfiz DConstanzo, Jerfiz DConstanzo, Jerfiz DVenkateswaran, NiranjanVenkateswaran, NiranjanVenkateswaran, NiranjanMelegari, MargheritaMelegari, MargheritaMelegari, MargheritaIlcheva, MariyaIlcheva, MariyaIlcheva, MariyaMorales, Julio CMorales, Julio CMorales, Julio CSkoulidis, FerdinandosSkoulidis, FerdinandosSkoulidis, FerdinandosHeymach, John VHeymach, John VHeymach, John VBoothman, David ABoothman, David ABoothman, David AScaglioni, Pier PaoloScaglioni, Pier Paolo and Scaglioni, Pier Paolo
Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 22, (no. 23), pp. 5863, 2016-Dec-01. | Journal Article
 
Galactic cosmic ray simulation at the NASA Space Radiation Laboratory
Norbury, John WNorbury, John WSchimmerling, WalterSchimmerling, WalterSlaba, Tony CSlaba, Tony CAzzam, Edouard IAzzam, Edouard IBadavi, Francis FBadavi, Francis FBaiocco, GiorgioBaiocco, GiorgioBenton, EricBenton, EricBindi, VeronicaBindi, VeronicaBlakely, Eleanor ABlakely, Eleanor ABlattnig, Steve RBlattnig, Steve RBoothman, David ABoothman, David ABorak, Thomas BBorak, Thomas BBritten, Richard ABritten, Richard ACurtis, StanCurtis, StanDingfelder, MichaelDingfelder, MichaelDurante, MarcoDurante, MarcoDynan, William SDynan, William SEisch, Amelia JEisch, Amelia JRobin Elgart, SRobin Elgart, SGoodhead, Dudley TGoodhead, Dudley TGuida, Peter MGuida, Peter MHeilbronn, Lawrence HHeilbronn, Lawrence HHellweg, Christine EHellweg, Christine EHuff, Janice LHuff, Janice LKronenberg, AmyKronenberg, AmyLa Tessa, ChiaraLa Tessa, ChiaraLowenstein, Derek ILowenstein, Derek IMiller, JackMiller, JackMorita, TakashiMorita, TakashiNarici, LivioNarici, LivioNelson, Gregory ANelson, Gregory ANorman, Ryan BNorman, Ryan BOttolenghi, AndreaOttolenghi, AndreaPatel, Zarana SPatel, Zarana SReitz, GuentherReitz, GuentherRusek, AdamRusek, AdamSchreurs, Ann-SofieSchreurs, Ann-SofieScott-Carnell, Lisa AScott-Carnell, Lisa ASemones, EdwardSemones, EdwardShay, Jerry WShay, Jerry WShurshakov, Vyacheslav AShurshakov, Vyacheslav ASihver, LembitSihver, LembitSimonsen, Lisa CSimonsen, Lisa CStory, Michael DStory, Michael DTurker, Mitchell STurker, Mitchell SUchihori, YukioUchihori, YukioWilliams, JacquelineWilliams, JacquelineZeitlin, Cary J and Zeitlin, Cary J
Life Sciences in Space Research, vol. 8, pp. 51, February 2016. | Journal Article
 
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors
Huang, XiumeiHuang, XiumeiHuang, XiumeiHuang, XiumeiMotea, Edward AMotea, Edward AMotea, Edward AMotea, Edward AMoore, Zachary RMoore, Zachary RMoore, Zachary RMoore, Zachary RYao, JunYao, JunYao, JunYao, JunDong, YingDong, YingDong, YingDong, YingChakrabarti, GaurabChakrabarti, GaurabChakrabarti, GaurabChakrabarti, GaurabKilgore, Jessica AKilgore, Jessica AKilgore, Jessica AKilgore, Jessica ASilvers, Molly ASilvers, Molly ASilvers, Molly ASilvers, Molly APatidar, Praveen LPatidar, Praveen LPatidar, Praveen LPatidar, Praveen LCholka, AgnieszkaCholka, AgnieszkaCholka, AgnieszkaCholka, AgnieszkaFattah, FarjanaFattah, FarjanaFattah, FarjanaFattah, FarjanaCha, YoonjeongCha, YoonjeongCha, YoonjeongCha, YoonjeongAnderson, Glenda GAnderson, Glenda GAnderson, Glenda GAnderson, Glenda GKusko, RebeccaKusko, RebeccaKusko, RebeccaKusko, RebeccaPeyton, MichaelPeyton, MichaelPeyton, MichaelPeyton, MichaelYan, JingshengYan, JingshengYan, JingshengYan, JingshengXie, Xian-JinXie, Xian-JinXie, Xian-JinXie, Xian-JinSarode, VenetiaSarode, VenetiaSarode, VenetiaSarode, VenetiaWilliams, Noelle SWilliams, Noelle SWilliams, Noelle SWilliams, Noelle SMinna, John DMinna, John DMinna, John DMinna, John DBeg, MuhammadBeg, MuhammadBeg, MuhammadBeg, MuhammadGerber, David EGerber, David EGerber, David EGerber, David EBey, Erik ABey, Erik ABey, Erik ABey, Erik ABoothman, David ABoothman, David ABoothman, David A and Boothman, David A
Cancer Cell, vol. 30, (no. 6), pp. 952, 2016-12-12. | Journal Article
 
Leveraging an NQO1 bioactivatable drug for tumor-selective use of poly (ADP-ribose) polymerase (PARP) inhibitors
Boothman, David A
Journal of Postgenomics Drug & Biomarker Development, vol. 6, (no. 3), 2016-00-00. | Journal Article
 
Lysosome-oriented, dual-stage pH-responsive polymeric micelles for β-lapachone delivery
Zhou, YinjianZhou, YinjianDong, YingDong, YingHuang, GangHuang, GangWang, YiguangWang, YiguangHuang, XiaonanHuang, XiaonanZhang, FayunZhang, FayunBoothman, David ABoothman, David AGao, JinmingGao, JinmingLiang, Wei and Liang, Wei
Journal of materials chemistry. B, vol. 4, (no. 46), pp. 7440, 2016-Dec-14. | Journal Article
 
Lysosome-oriented, dual-stage pH-responsive polymeric micelles for β-lapachone deliveryElectronic supplementary information (ESI) available. See DOI: 10.1039/c6tb02049f
Zhou, YinjianDong, YingHuang, GangWang, YiguangHuang, XiaonanZhang, FayunBoothman, David AGao, Jinming and Liang, Wei
(no. 46), pp. 744, 20161123. | Journal Article
 
NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer
Li, Long-ShanLi, Long-ShanReddy, SrilakshmiReddy, SrilakshmiLin, Zhen-HuaLin, Zhen-HuaLiu, ShuangpingLiu, ShuangpingPark, HyunsilPark, HyunsilChun, Stephen GChun, Stephen GBornmann, William GBornmann, William GThibodeaux, JoelThibodeaux, JoelYan, JingshengYan, JingshengChakrabarti, GaurabChakrabarti, GaurabXie, Xian-JinXie, Xian-JinSumer, Baran DSumer, Baran DBoothman, David ABoothman, David AYordy, John S and Yordy, John S
Molecular cancer therapeutics, vol. 15, (no. 7), pp. 1767, 2016-07-00. | Journal Article
 
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights
da Cruz, Eduardo H.GSilvers, Molly AJardim, Guilherme A.MResende, Jarbas MCavalcanti, Bruno CBomfim, Igor SPessoa, Claudiade Simone, Carlos ABotteselle, Giancarlo VBraga, Antonio LNair, Divya KNamboothiri, Irishi N.NBoothman, David A and da Silva Júnior, Eufrânio N
European Journal of Medicinal Chemistry, vol. 122, pp. 16, 2016-10-21. | Journal Article
 
The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair
Patidar, Praveen LPatidar, Praveen LPatidar, PraveenMotea, Edward AMotea, EdwardMotea, Edward AFattah, FarjanaFattah, Farjana JFattah, Farjana JZhou, YunyunZhou, YunyunZhou, YunyunMorales, Julio CMorales, Julio CMorales, JulioXie, YangXie, YangXie, YangGarner, HaroldGarner, Harold RGarner, Harold RBoothman, David ABoothman, David and Boothman, David A
2016-02-29. | Journal Article
 
Using DNA devices to track anticancer drug activity
Kahanda, DimithreeKahanda, DimithreeChakrabarti, GaurabChakrabarti, GaurabMcwilliams, Marc AMcwilliams, Marc ABoothman, David ABoothman, David ASlinker, Jason D and Slinker, Jason D
Biosensors and Bioelectronics, vol. 80, pp. 653, 2016-06-15. | Journal Article
 
XRN2 Links Transcription Termination to DNA Damage and Replication Stress
Morales, JulioMorales, JulioMorales, Julio CMorales, Julio CJulio C MoralesRichard, PatriciaPatricia RichardRichard, PatriciaRichard, PatriciaRichard, PatriciaPraveen L PatidarPatidar, PraveenPatidar, PraveenPatidar, Praveen LPatidar, Praveen LMotea, Edward AEdward A MoteaMotea, Edward AMotea, EdwardMotea, EdwardTuyen T DangDang, TuyenDang, Tuyen TDang, Tuyen TDang, TuyenManley, JamesManley, James LManley, James LManley, JamesJames L ManleyBoothman, David ABoothman, DavidBoothman, DavidDavid A Boothman and Boothman, David A
2016. | Journal Article