Our lab has been focusing on the role of Tamm-Horsfall protein (Uromodulin) in Kidney Injury and inflammation.
Our current investigations are aimed at defining the molecular mechanism involved in this regulation, with a long term goal of using such insights to design novel therapeutic tools to treat patient with Acute Kidney Injury.
We also developed advanced expertise in performing immuno-fluorescence guided Laser Micro-dissection (LMD) to dissect specific nephron segments for down-stream transcriptomic and proteomic analysis.
Because of our expertise in tissue interrogation, we also developed interest in uncovering cellular and molecular omics signatures from human biopsy tissue to correlate with disease phenotype and outcomes.
Using this approach, we are currently involved in a large cooperative study to understand the pathogenesis of human kidney stone disease by molecular interrogation of kidney papillary biopsies taken during surgery.
Clinical Interests:
- Acute Kidney Injury
- Uromodulin associated kidney disease
Research: Complication of Diabetes and Obesity
Keywords:
- Cell Biology of Acute Kidney Injury
- Progressive Chronic Kidney Disease
- Chromodulin
