21 Publications
2020
Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy
Singh, Naveen⋅Pay, S Louise⋅Bhandare, Snehal B⋅Arimpur, Udhaya and Motea, Edward A
Cancers, vol. 12, (no. 4), pp. 972, 2020-Apr-14. | Journal Article
 
XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition
Patidar, Praveen L⋅Patidar, Praveen L⋅Talysa, Viera⋅Talysa, Viera⋅Morales, Julio C⋅Morales, Julio C⋅Singh, Naveen⋅Singh, Naveen⋅Motea, Edward A⋅Motea, Edward A⋅Fattah, Farjana J and Fattah, Farjana J
Scientific Reports (Nature Publisher Group), vol. 10, (no. 1), 2020. | Journal Article
2019
NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers
Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Williams, Noelle S⋅Williams, Noelle S⋅Williams, Noelle S⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Gerber, David E⋅Gerber, David E⋅Gerber, David E⋅Beg, Muhammad S⋅Beg, Muhammad S⋅Beg, Muhammad S⋅Bey, Erik A⋅Bey, Erik A⋅Bey, Erik A⋅Boothman, David A⋅Boothman, David A and Boothman, David A
Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 25, (no. 8), pp. 2609, 2019-04-15. | Journal Article
2018
Kub5-HeraRPRD1B Deficiency Promotes “BRCAness” and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers
Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Fattah, Farjana J⋅Fattah, Farjana J⋅Fattah, Farjana J⋅Xiao, Ling⋅Xiao, Ling⋅Xiao, Ling⋅Girard, Luc⋅Girard, Luc⋅Girard, Luc⋅Rommel, Amy⋅Rommel, Amy⋅Rommel, Amy⋅Morales, Julio C⋅Morales, Julio C⋅Morales, Julio C⋅Patidar, Praveen⋅Patidar, Praveen⋅Patidar, Praveen⋅Zhou, Yunyun⋅Zhou, Yunyun⋅Zhou, Yunyun⋅Porter, Andrew⋅Porter, Andrew⋅Porter, Andrew⋅Xie, Yang⋅Xie, Yang⋅Xie, Yang⋅Minna, John D⋅Minna, John D⋅Minna, John D⋅Boothman, David A⋅Boothman, David A and Boothman, David A
Clinical Cancer Research, vol. 24, (no. 24), pp. 6470, 2018-12-15. | Journal Article
 
Modulators of Redox Metabolism in Head and Neck Cancer.
Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Furdui, Cristina M⋅Furdui, Cristina M⋅Furdui, Cristina M⋅Furdui, Cristina M⋅Furdui, Cristina M⋅Furdui, Cristina M and Furdui, Cristina M
Antioxidants & redox signaling, vol. 29, (no. 16), pp. 1660-1690, December 1, 2018. | Journal Article
2017
Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents
Choi, Jung-Suk⋅Kim, Seol⋅Motea, Edward and Berdis, Anthony
Oncotarget, vol. 8, (no. 25), pp. 40816, 2017-Jun-20. | Journal Article
2016
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors
Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Moore, Zachary R⋅Moore, Zachary R⋅Moore, Zachary R⋅Moore, Zachary R⋅Yao, Jun⋅Yao, Jun⋅Yao, Jun⋅Yao, Jun⋅Dong, Ying⋅Dong, Ying⋅Dong, Ying⋅Dong, Ying⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Silvers, Molly A⋅Silvers, Molly A⋅Silvers, Molly A⋅Silvers, Molly A⋅Patidar, Praveen L⋅Patidar, Praveen L⋅Patidar, Praveen L⋅Patidar, Praveen L⋅Cholka, Agnieszka⋅Cholka, Agnieszka⋅Cholka, Agnieszka⋅Cholka, Agnieszka⋅Fattah, Farjana⋅Fattah, Farjana⋅Fattah, Farjana⋅Fattah, Farjana⋅Cha, Yoonjeong⋅Cha, Yoonjeong⋅Cha, Yoonjeong⋅Cha, Yoonjeong⋅Anderson, Glenda G⋅Anderson, Glenda G⋅Anderson, Glenda G⋅Anderson, Glenda G⋅Kusko, Rebecca⋅Kusko, Rebecca⋅Kusko, Rebecca⋅Kusko, Rebecca⋅Peyton, Michael⋅Peyton, Michael⋅Peyton, Michael⋅Peyton, Michael⋅Yan, Jingsheng⋅Yan, Jingsheng⋅Yan, Jingsheng⋅Yan, Jingsheng⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Sarode, Venetia⋅Sarode, Venetia⋅Sarode, Venetia⋅Sarode, Venetia⋅Williams, Noelle S⋅Williams, Noelle S⋅Williams, Noelle S⋅Williams, Noelle S⋅Minna, John D⋅Minna, John D⋅Minna, John D⋅Minna, John D⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Gerber, David E⋅Gerber, David E⋅Gerber, David E⋅Gerber, David E⋅Bey, Erik A⋅Bey, Erik A⋅Bey, Erik A⋅Bey, Erik A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A and Boothman, David A
Cancer Cell, vol. 30, (no. 6), pp. 952, 2016-12-12. | Journal Article
 
The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair
Patidar, Praveen L⋅Patidar, Praveen L⋅Patidar, Praveen⋅Motea, Edward A⋅Motea, Edward⋅Motea, Edward A⋅Fattah, Farjana⋅Fattah, Farjana J⋅Fattah, Farjana J⋅Zhou, Yunyun⋅Zhou, Yunyun⋅Zhou, Yunyun⋅Morales, Julio C⋅Morales, Julio C⋅Morales, Julio⋅Xie, Yang⋅Xie, Yang⋅Xie, Yang⋅Garner, Harold⋅Garner, Harold R⋅Garner, Harold R⋅Boothman, David A⋅Boothman, David and Boothman, David A
Nucleic acids research, vol. 44, (no. 4), pp. 1731, 2016-Feb-29. | Journal Article
 
XRN2 Links Transcription Termination to DNA Damage and Replication Stress
Morales, Julio⋅Morales, Julio⋅Morales, Julio C⋅Morales, Julio C⋅Julio C Morales⋅Richard, Patricia⋅Patricia Richard⋅Richard, Patricia⋅Richard, Patricia⋅Richard, Patricia⋅Praveen L Patidar⋅Patidar, Praveen⋅Patidar, Praveen⋅Patidar, Praveen L⋅Patidar, Praveen L⋅Motea, Edward A⋅Edward A Motea⋅Motea, Edward A⋅Motea, Edward⋅Motea, Edward⋅Tuyen T Dang⋅Dang, Tuyen⋅Dang, Tuyen T⋅Dang, Tuyen T⋅Dang, Tuyen⋅Manley, James⋅Manley, James L⋅Manley, James L⋅Manley, James⋅James L Manley⋅Boothman, David A⋅Boothman, David⋅Boothman, David⋅David A Boothman and Boothman, David A
PLoS genetics, vol. 12, (no. 7), pp. e1006107, 2016-07-00. | Journal Article
2015
Abstract LB-071: Kub5-Hera/RPRD1B controls CDK1 regulation and synthetic lethality to PARP1 inhibition
Motea, Edward A⋅Motea, Edward A⋅Fattah, Farjana⋅Fattah, Farjana⋅Xiao, Ling⋅Xiao, Ling⋅Girard, Luc⋅Girard, Luc⋅Rommel, Amy⋅Rommel, Amy⋅Morales, Julio⋅Morales, Julio⋅Patidar, Praveen⋅Patidar, Praveen⋅Porter, Andrew⋅Porter, Andrew⋅Minna, John⋅Minna, John⋅Boothman, David and Boothman, David
Cancer Research, vol. 75, (no. 15 Supplement), pp. LB-071, 2015-08-01. | Journal Article
2014
Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair
Morales, Julio C⋅Morales, Julio C⋅Morales, Julio C⋅Richard, Patricia⋅Richard, Patricia⋅Richard, Patricia⋅Rommel, Amy⋅Rommel, Amy⋅Rommel, Amy⋅Fattah, Farjana J⋅Fattah, Farjana J⋅Fattah, Farjana J⋅Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Patidar, Praveen L⋅Patidar, Praveen L⋅Patidar, Praveen L⋅Xiao, Ling⋅Xiao, Ling⋅Xiao, Ling⋅Leskov, Konstantin⋅Leskov, Konstantin⋅Leskov, Konstantin⋅Wu, Shwu-Yuan⋅Wu, Shwu-Yuan⋅Wu, Shwu-Yuan⋅Hittelman, Walter N⋅Hittelman, Walter N⋅Hittelman, Walter N⋅Chiang, Cheng-Ming⋅Chiang, Cheng-Ming⋅Chiang, Cheng-Ming⋅Manley, James L⋅Manley, James L⋅Manley, James L⋅Boothman, David A⋅Boothman, David and Boothman, David A
Nucleic Acids Research, vol. 42, (no. 8), pp. 5006, 20140400. | Journal Article
 
Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers
Cao, Lifen⋅Cao, Lifen⋅Cao, Lifen⋅Cao, Lifen⋅Li, Long Shan⋅Li, Long Shan⋅Li, Long Shan⋅Li, Long Shan⋅Spruell, Christopher⋅Spruell, Christopher⋅Spruell, Christopher⋅Spruell, Christopher⋅Xiao, Ling⋅Xiao, Ling⋅Xiao, Ling⋅Xiao, Ling⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Bey, Erik A⋅Bey, Erik A⋅Bey, Erik A⋅Bey, Erik A⋅Reinicke, Kathryn E⋅Reinicke, Kathryn E⋅Reinicke, Kathryn E⋅Reinicke, Kathryn E⋅Srougi, Melissa C⋅Srougi, Melissa C⋅Srougi, Melissa C⋅Srougi, Melissa C⋅Moore, Zachary⋅Moore, Zachary⋅Moore, Zachary⋅Moore, Zachary⋅Dong, Ying⋅Dong, Ying⋅Dong, Ying⋅Dong, Ying⋅Vo, Peggy⋅Vo, Peggy⋅Vo, Peggy⋅Vo, Peggy⋅Kabbani, Wareef⋅Kabbani, Wareef⋅Kabbani, Wareef⋅Kabbani, Wareef⋅Yang, Chin-Rang⋅Yang, Chin-Rang⋅Yang, Chin-Rang⋅Yang, Chin-Rang⋅Wang, Xiaoyu⋅Wang, Xiaoyu⋅Wang, Xiaoyu⋅Wang, Xiaoyu⋅Fattah, Farjana⋅Fattah, Farjana⋅Fattah, Farjana⋅Fattah, Farjana⋅Morales, Julio C⋅Morales, Julio C⋅Morales, Julio C⋅Morales, Julio C⋅Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Bornmann, William G⋅Bornmann, William G⋅Bornmann, William G⋅Bornmann, William G⋅Yordy, John S⋅Yordy, John S⋅Yordy, John S⋅Yordy, John S⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A and Boothman, David A
Antioxidants & Redox Signaling, vol. 21, (no. 2), pp. 250, 2014-07-10. | Journal Article
2013
Development and Characterization of a Non-natural Nucleoside that Displays Anticancer Activity Against Solid Tumors
Golden, Jackelyn⋅Golden, Jackelyn⋅Motea, Edward⋅Motea, Edward⋅Zhang, Xuemei⋅Zhang, Xuemei⋅Choi, Jung-Suk⋅Choi, Jung-Suk⋅Feng, Ye⋅Feng, Ye⋅Xu, Yan⋅Xu, Yan⋅Lee, Irene⋅Lee, Irene⋅Berdis, Anthony J and Berdis, Anthony J
ACS Chemical Biology, vol. 8, (no. 11), pp. 2465, 20131115. | Journal Article
 
Insights into the Roles of Desolvation and π‐Electron Interactions during DNA Polymerization
Motea, Edward A⋅Motea, Edward A⋅Lee, Irene⋅Lee, Irene⋅Berdis, Anthony J and Berdis, Anthony J
ChemBioChem, vol. 14, (no. 4), pp. 498, March 4, 2013. | Journal Article
2012
A Non-natural Nucleoside with Combined Therapeutic and Diagnostic Activities against Leukemia
Motea, Edward A⋅Motea, Edward A⋅Lee, Irene⋅Lee, Irene⋅Berdis, Anthony J and Berdis, Anthony J
ACS Chemical Biology, vol. 7, (no. 6), pp. 998, 20120615. | Journal Article
 
Development of a 'clickable' non-natural nucleotide to visualize the replication of non-instructional DNA lesions
Motea, Edward A⋅Motea, Edward A⋅Lee, Irene⋅Lee, Irene⋅Berdis, Anthony J and Berdis, Anthony J
Nucleic Acids Research, vol. 40, (no. 5), pp. 2367, 20120300. | Journal Article
 
Evaluating the Therapeutic Potential of a Non-Natural Nucleotide That Inhibits Human Ribonucleotide Reductase
Ahmad, Md F⋅Ahmad, Md Faiz⋅Wan, Qun⋅Wan, Qun⋅Jha, Shalini⋅Jha, Shalini⋅Motea, Edward⋅Motea, Edward⋅Berdis, Anthony⋅Berdis, Anthony⋅Dealwis, Chris G and Dealwis, Chris
Molecular cancer therapeutics, vol. 11, (no. 10), pp. 2086, 2012-Oct. | Journal Article
2011
Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis
Motea, Edward A⋅Motea, Edward A⋅Lee, Irene⋅Lee, Irene⋅Berdis, Anthony J and Berdis, Anthony J
Nucleic acids research, vol. 39, (no. 4), pp. 1637, 2011-Mar. | Journal Article
2010
Replication of a Universal Nucleobase Provides Unique Insight into the Role of Entropy during DNA Polymerization and Pyrophosphorolysis
Zhang, Xuemei⋅Zhang, Xuemei⋅Motea, Edward⋅Motea, Edward⋅Lee, Irene⋅Lee, Irene⋅Berdis, Anthony J and Berdis, Anthony J
Biochemistry, vol. 49, (no. 14), pp. 3023, 20100413. | Journal Article
 
Terminal deoxynucleotidyl transferase: The story of a misguided DNA polymerase
Motea, Edward A⋅Motea, Edward A⋅Berdis, Anthony J and Berdis, Anthony J
BBA - Proteins and Proteomics, vol. 1804, (no. 5), pp. 1166, 2010. | Journal Article
2008
Mechanism and Dynamics of Translesion DNA Synthesis Catalyzed by the Escherichia coli Klenow Fragment
Sheriff, Asim⋅Sheriff, Asim⋅Motea, Edward⋅Motea, Edward⋅Lee, Irene⋅Lee, Irene⋅Berdis, Anthony J and Berdis, Anthony J
Biochemistry, vol. 47, (no. 33), pp. 8537, 20080819. | Journal Article