She has been a faculty member at Indiana University since 1992, and in 2019 was named Distinguished Professor at IU. Dr. Moe is the principal investigator for several ongoing basic and clinical research studies in the field of Chronic Kidney Disease -Mineral Bone Disorder (CKD-MBD), including studies on vascular calcification, mineral metabolism and bone metabolism in kidney disease.
My research investigates the relationship of kidney disease, vascular calcification, bone, and disorders of mineral metabolism known as CKD-Mineral Bone Disorder (CKD-MBD).
We are using a naturally occurring rat model of CKD that spontaneously develops all manifestations of CKD-MBD to study 1) mechanisms by which matrix vesicles propagate arterial calcification, 2) how oxidative stress alters vasculature, 3) the role of advanced glycation end product cross linking of bone collagen predisposes to fracture, 4) mechanisms of sudden cardiac death, 5) how impaired muscle function occurs with progressive CKD, and 6) micro RNA as biomarkers. We also have active investigator initiated clinical trials studying the natural progression of frailty and muscle weakness in patients as they start on dialysis, novel phosphate binders and the effect on phosphate balance, how nutrition can be enhanced in patients on dialysis, and the use of pioglitazone as a treatment for ADPKD.
My clinical interests focus on the prevention and treatment of kidney stones using diet and medications. In addition I specialize in the treatment of bone disease in patients with kidney disease, and disorders of magnesium and calcium.
Subject area:
Research: Complication of Diabetes and Obesity
Keywords:
- Vascular Calcification
- Bone Loss
- Oxidative Stress
- Exercise and Muscle Loss
