The Bellido laboratory studies osteocytes and their role in regulating the function of osteoblasts and osteoclasts in response to hormonal and mechanical stimuli. They study the regulation of osteocyte-derived genes by parathyroid hormone (PTH), the mechanisms by which PTH and mechanical force regulate bone homeostasis through actions on osteocytes, and the antagonistic interplay between glucocorticoids and mechanical stimulation in bone.