40 Publications (Page 1 of 2)
2010
Cyanide-induced apoptosis of dopaminergic cells is promoted by BNIP3 and Bax modulation of endoplasmic reticulum-mitochondrial Ca2+ levels.
Zhang, Lu⋅Li, Li⋅Leavesley, Heather W⋅Zhang, Xun⋅Borowitz, Joseph L and Isom, Gary E
The Journal of pharmacology and experimental therapeutics, vol. 332, (no. 1), pp. 97-105, 2010/Jan. | Journal Article
 
Nitrite-mediated antagonism of cyanide inhibition of cytochrome c oxidase in dopamine neurons.
Leavesley, Heather B⋅Li, Li⋅Mukhopadhyay, Soma⋅Borowitz, Joseph L and Isom, Gary E
Toxicological sciences : an official journal of the Society of Toxicology, vol. 115, (no. 2), pp. 569-76, 2010/Jun. | Journal Article
2009
BNIP3 mediates cell death by different pathways following localization to endoplasmic reticulum and mitochondrion.
Zhang, Lu⋅Li, Li⋅Liu, Han⋅Borowitz, Joseph L and Isom, Gary E
FASEB journal., vol. 23, (no. 10), pp. 3405-3414, 2009. | Journal Article
 
Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression
Zhang, X.⋅Li, L.⋅Zhang, L.⋅Borowitz, Joseph L and Isom, Gary E
Toxicology and Applied Pharmacology, vol. 238, (no. 1), pp. 11-19, 2009. | Journal Article
2008
Interaction of Cyanide and Nitric Oxide with Cytochrome c Oxidase: Implications for Acute Cyanide Toxicity
Leavesley, Heather B⋅Li, Li⋅Prabhakaran, Krishnan⋅Borowitz, Joseph L and Isom, Gary E
Toxicological Sciences, vol. 101, (no. 1), pp. 101-111, 2008. | Journal Article
 
Nicotine and Type 2 Diabetes
Borowitz, Joseph L and Isom, Gary E
Toxicological Sciences, vol. 103, (no. 2), pp. 225-227, 2008. | Journal Article
2007
HIF-1 alpha activation by a redox-sensitive pathway mediates cyanide-induced BNIP3 upregulation and mitochondrial-dependent cell death
Zhang, L.⋅Li, L.⋅Liu, H.⋅Prabhakaran, Krishnan⋅Zhang, X.⋅Borowitz, Joseph L and Isom, Gary E
Free Radical Biology and Medicine, vol. 43, (no. 1), pp. 117-127, 2007. | Journal Article
 
Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPAR alpha activation and oxidative stress
Zhang, X.⋅Li, L.⋅Prabhakaran, Krishnan⋅Zhang, L.⋅Leavesley, HB⋅Borowitz, Joseph L and Isom, Gary E
Toxicology and Applied Pharmacology, vol. 223, (no. 1), pp. 10-19, 2007. | Journal Article
 
Upregulation of BNIP3 and translocation to mitochondria mediates cyanide-induced apoptosis in cortical cells
Prabhakaran, Krishnan⋅Li, L.⋅Zhang, L.⋅Borowitz, Joseph L and Isom, Gary E
Neuroscience, vol. 150, (no. 1), pp. 159-167, 2007. | Journal Article
2006
PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells.
Li, Li⋅Prabhakaran, Krishnan⋅Zhang, Xun⋅Borowitz, Joseph L and Isom, Gary E
Toxicological sciences : an official journal of the Society of Toxicology, vol. 93, (no. 1), pp. 136-45, 2006/Sep. | Journal Article
 
PPAR alpha -Mediated Upregulation of Uncoupling Protein-2 Switches Cyanide-Induced Apoptosis to Necrosis in Primary Cortical Cells
Li, Li⋅Prabhakaran, Krishnan⋅Zhang, Xun⋅Borowitz, Joseph L and Isom, Gary E
Toxicological Sciences, vol. 93, (no. 1), pp. 136-145, 2006. | Journal Article
 
Trimethyltin-induced apoptosis is associated with upregulation of inducible nitric oxide synthase and Bax in a hippocampal cell line
Zhang, L.⋅Li, L.⋅Prabhakaran, Krishnan⋅Borowitz, Joseph L and Isom, Gary E
Toxicology and Applied Pharmacology, vol. 216, (no. 1), pp. 34-43, 2006. | Journal Article
2005
Up-regulation of uncoupling protein 2 by cyanide is linked with cytotoxicity in mesencephalic cells.
Prabhakaran, Krishnan⋅Li, Li⋅Mills, Edward M⋅Borowitz, Joseph L and Isom, Gary E
The Journal of pharmacology and experimental therapeutics, vol. 314, (no. 3), pp. 1338-45, 2005/Sep. | Journal Article
2004
Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis.
Shou, Yan⋅Li, Li⋅Prabhakaran, Krishnan⋅Borowitz, Joseph L and Isom, Gary E
The Biochemical journal, vol. 379, (no. Pt 3), pp. 805-13, 2004/May/1. | Journal Article
 
Caspase inhibition switches the mode of cell death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation.
Prabhakaran, Krishnan⋅Li, Li⋅Borowitz, Joseph L and Isom, Gary E
Toxicology and applied pharmacology, vol. 195, (no. 2), pp. 194-202, 2004/Mar/1. | Journal Article
2003
Cyanide enhancement of dopamine-induced apoptosis in mesencephalic cells involves mitochondrial dysfunction and oxidative stress.
Jones, Douglas C⋅Prabhakaran, Krishnan⋅Li, Li⋅Gunasekar, Palur G⋅Shou, Yan⋅Borowitz, Joseph L and Isom, Gary E
Neurotoxicology, vol. 24, (no. 3), pp. 333-42, 2003/Jun. | Journal Article
 
p38 Mitogen-activated protein kinase regulates Bax translocation in cyanide-induced apoptosis.
Shou, Y⋅Li, L⋅Prabhakaran, Krishnan⋅Borowitz, Joseph L and Isom, Gary E
Toxicological sciences : an official journal of the Society of Toxicology, vol. 75, (no. 1), pp. 99-107, 2003/Sep. | Journal Article
2002
NF-kappaB-mediated up-regulation of Bcl-X(S) and Bax contributes to cytochrome c release in cyanide-induced apoptosis.
Shou, Yan⋅Li, Nianyu⋅Li, Li⋅Borowitz, Joseph L and Isom, Gary E
Journal of neurochemistry, vol. 81, (no. 4), pp. 842-52, 2002/May. | Journal Article
 
NF- Kappa B-mediated up-regulation of Bcl-X sub(S) and Bax contributes to cytochrome c release in cyanide-induced apoptosis
Shou, Y.⋅Li, N.⋅Li, L.⋅Borowitz, Joseph L and Isom, Gary E
Journal of Neurochemistry, vol. 81, (no. 4), pp. 842-852, 2002. | Journal Article
 
Oxidative Stress and Cyclooxygenase-2 Induction Mediate Cyanide-Induced Apoptosis of Cortical Cells
Li, L.⋅Prabhakaran, Krishnan⋅Shou, Y.⋅Borowitz, Joseph L and Isom, Gary E
Toxicology and Applied Pharmacology, vol. 185, (no. 1), pp. 55-63, 2002. | Journal Article
2001
Mechanisms of the Apoptotic and Necrotic Actions of Trimethyltin in Cerebellar Granule Cells
Gunasekar, P.⋅Li, L.⋅Prabhakaran, Krishnan⋅Eybl, V.⋅Borowitz, Joseph L and Isom, Gary E
Toxicological Sciences, vol. 64, (no. 1), pp. 83-89, 2001. | Journal Article
 
Reactive Oxygen Species Mediate Pyridostigmine-Induced Neuronal Apoptosis: Involvement of Muscarinic and NMDA Receptors
Li, L.⋅Shou, Y.⋅Borowitz, Joseph L and Isom, Gary E
Toxicology and Applied Pharmacology, vol. 177, (no. 1), pp. 17-25, 2001. | Journal Article
2000
Cyanide-induced apoptosis involves oxidative-stress-activated NF-kappaB in cortical neurons.
Shou, Y⋅Gunasekar, P G⋅Borowitz, Joseph L and Isom, G E
Toxicology and applied pharmacology, vol. 164, (no. 2), pp. 196-205, 2000/Apr/15. | Journal Article
 
Dopamine-induced apoptosis is mediated by oxidative stress and Is enhanced by cyanide in differentiated PC12 cells.
Jones, D C⋅Gunasekar, P G⋅Borowitz, Joseph L and Isom, Gary E
Journal of neurochemistry, vol. 74, (no. 6), pp. 2296-304, 2000/Jun. | Journal Article
 
Endogenous generation of cyanide in neuronal tissue: involvement of a peroxidase system.
Gunasekar, P G⋅Borowitz, Joseph L⋅Turek, John J⋅Van Horn, D A and Isom, Gary E
Journal of neuroscience research, vol. 61, (no. 5), pp. 570-5, 2000/Sep/1. | Journal Article