The Yang laboratory is interested in understanding fundamental mechanisms by which T cells coordinate immune signals and cellular metabolism in maintaining immune homeostasis and preventing allergic inflammation. Using mouse models with genetic interference of mTOR signaling and systems biology approaches, the lab aims to identify key molecular and metabolic components involved in the initiation and progression of allergic diseases. Dr. Yang’s lab also investigates the role of metabolic remodeling in regulating T-cell quiescence.

My research has focused on elucidating fundamental mechanisms that coordinate immune signals and cellular metabolism in the control of T cell homeostasis, differentiation and function.

I have a long-standing interest in understanding molecular and metabolic mechanisms involved in regulating T cell quiescence and activation.

In addition, I also actively investigate regulatory mechanisms governing the stability and functional integrity of Treg cells, which suppress T cell immune responses in the tumor microenvironment.

With the extensive research experience in T cell biology, I would like to elucidate regulatory mechanisms governing T cell responses in the tumor microenvironment in the following aspects: (1) Identification of immune and metabolic checkpoints that restrain T cell responses in the tumor microenvironment. (2) Elucidation of molecular and metabolic mechanisms that modulate Treg cell stability and functional integrity in suppressing T cell immunity in the tumor microenvironment. (3) Investigation of regulatory mechanisms that control the infiltration of T cells into tumors.

Subject Areas:

  • Pulmonary Asthma Allergy
Oncology, Pediatrics, Rheumatology/Allergy, Pulmonary and Critical Care Medicine
PHD, University of the Chinese Academy of Sciences, Biochemistry, Cell Biology, 2008
BS, Southwest University, Biopharmacy, 2001