52 Publications (Page 2 of 3)
2017
Declined Presentation Inhibition of carbonic anhydrase IX as a novel strategy to target FLT3/ITD mutated aml cells under hypoxic conditionsKonig, Heiko⋅Konig, Heiko⋅Chen, Fangli⋅Chen, Fangli⋅Rogozea, Adriana⋅Rogozea, Adriana⋅Kinnebrew, Garrett⋅Kinnebrew, Garrett⋅Ivan, Mircea and Ivan, MirceaExperimental Hematology, vol. 53, pp. S88, September 2017.
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Enzyme-immobilized hydrogels to create hypoxia for in vitro cancer cell cultureDawes, Camron S⋅Dawes, Camron S.⋅Konig, Heiko⋅Konig, Heiko⋅Lin, Chien-Chi and Lin, Chien ChiJournal of Biotechnology, vol. 248, pp. 34, 2017-04-20.
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Immunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic MicroenvironmentGbolahan, Olumide Babajide⋅Gbolahan, Olumide Babajide⋅Gbolahan, Olumide Babajide⋅Zeidan, Amer M⋅Zeidan, Amer M⋅Zeidan, Amer M⋅Zeidan, Amer M⋅Stahl, Maximilian⋅Stahl, Maximilian⋅Stahl, Maximilian⋅Stahl, Maximilian⋅Abu Zaid, Mohammad⋅Abu Zaid, Mohammad⋅Abu Zaid, Mohammad⋅Farag, Sherif⋅Farag, Sherif⋅Farag, Sherif⋅Farag, Sherif⋅Paczesny, Sophie⋅Paczesny, Sophie⋅Paczesny, Sophie⋅Paczesny, Sophie⋅Konig, Heiko⋅Konig, Heiko⋅Konig, Heiko and Konig, HeikoInternational journal of molecular sciences, vol. 18, (no. 8), pp. 1660, 2017-Jul-31.
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2016
Reduced Chemosensitivity of FLT3/ITD Mutated Cells to Cytarabine and Quizartinib Under Hypoxic ConditionsKonig, Heiko⋅Konig, Heiko⋅Rogozea, Adriana L⋅Rogozea, Adriana L⋅Kinnebrew, Garrett H⋅Kinnebrew, Garrett H⋅Ivan, Mircea and Ivan, MirceaBlood, vol. 128, (no. 22), pp. 1579, 2016-12-02.
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The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells.Chang, E⋅Ganguly, S⋅Rajkhowa, T⋅Gocke, C D⋅Levis, M and Konig, HLeukemia, vol. 30, (no. 5), pp. 1025-1032, May 2016.
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2015
Pilot study of erlotinib in patients with acute myeloid leukemia.Sayar, Hamid⋅Sayar, Hamid⋅Czader, Magdalena⋅Czader, Magdalena⋅Amin, Chirag⋅Amin, Chirag⋅Cangany, Mary⋅Cangany, Mary⋅Konig, Heiko⋅Konig, Heiko⋅Cripe, Larry and Cripe, Larry DLeukemia research, vol. 39, (no. 2), pp. 170-172, February 2015.
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Signal transduction in Acute Myeloid Leukemia - Implications for Novel Therapeutic Concepts.Konig, Heiko and Santos, Cedric DosCurrent cancer drug targets, vol. 15, (no. 9), pp. 803-821, 2015.
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Targeting FLT3 to treat leukemia.Konig, Heiko and Levis, MarkExpert opinion on therapeutic targets, vol. 19, (no. 1), pp. 37-54, January 2015.
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The Combination of the Novel Syk Inhibitor TAK659 with Decitabine Exerts Synergistic Cytotoxic Effects Against FLT3/ITD Mutated Acute Myeloid Leukemia CellsStage, Edwin⋅Stage, Edwin⋅Stage, Edwin⋅Czader, Magdalena⋅Czader, Magdalena⋅Czader, Magdalena⋅O'Leary, Heather⋅O'Leary, Heather⋅O'Leary, Heather⋅Boswell, H. Scott⋅Boswell, H. Scott⋅Boswell, H. Scott⋅Cripe, Larry D⋅Cripe, Larry D⋅Cripe, Larry D⋅Sayar, Hamid⋅Sayar, Hamid⋅Sayar, Hamid⋅Dos Santos, Cedric⋅Dos Santos, Cedric⋅Dos Santos, Cedric⋅Levis, Mark J⋅Levis, Mark J⋅Levis, Mark J⋅Konig, Heiko⋅Konig, Heiko and Konig, HeikoBlood, vol. 126, (no. 23), pp. 4928, 2015-12-03.
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You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia.Sehgal, A R⋅Konig, H⋅Johnson, D E⋅Tang, D⋅Amaravadi, R K⋅Boyiadzis, M and Lotze, M TLeukemia, vol. 29, (no. 3), pp. 517-525, March 2015.
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2014
Is targeted therapy feasible in acute myelogenous leukemia?Konig, Heiko⋅Konig, Heiko⋅Levis, Mark and Levis, MarkCurrent hematologic malignancy reports, vol. 9, (no. 2), pp. 118-127, June 2014.
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2013
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.Zhu, Jiewen⋅Zhu, Jiewen⋅Zhou, Longen⋅Zhou, Longen⋅Wu, Guikai⋅Wu, Guikai⋅Konig, Heiko⋅Konig, Heiko⋅Lin, Xiaoqin⋅Lin, Xiaoqin⋅Li, Guideng⋅Li, Guideng⋅Qiu, Xiao-Long⋅Qiu, Xiao-Long⋅Chen, Chi-Fen⋅Chen, Chi-Fen⋅Hu, Chun-Mei⋅Hu, Chun-Mei⋅Goldblatt, Erin⋅Goldblatt, Erin⋅Bhatia, Ravi⋅Bhatia, Ravi⋅Chamberlin, A Richard⋅Chamberlin, A Richard⋅Chen, Phang-Lang⋅Chen, Phang Lang⋅Lee, Wen-Hwa and Lee, Wen-HwaEMBO molecular medicine, vol. 5, (no. 3), pp. 353-365, March 2013.
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The Combination Of FLT3 Inhibition and Hypomethylation Confers Synergistic Anti-Leukemic Effects On FLT3/ITD Positive AML Cell Lines and Primary CellsKonig, Heiko and Levis, MarkBlood, vol. 122, (no. 21), pp. 3965, 2013-11-15.
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2012
Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling.Nam, Sangkil⋅Scuto, Anna⋅Yang, Fan⋅Chen, Wen Yong⋅Park, Sungman⋅Yoo, Hwa-Seung⋅Konig, Heiko⋅Bhatia, Ravi⋅Cheng, Xinlai⋅Merz, Karl-Heinz⋅Eisenbrand, Gerhard and Jove, RichardMolecular oncology, vol. 6, (no. 3), pp. 276-83, 2012/Jun.
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2009
The Sal-Like 1 (SALL1) Protein is Highly Expressed in Primary Bone Marrow Cells Derived From Patients with Acute Myeloid LeukemiaKonig, Heiko⋅Kiefer, Susan⋅Robbins, Lynn⋅Rauchman, Michael and Salman, Huda SBlood, vol. 114, (no. 22), pp. 1285, 2009-11-20.
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2008
Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606.Konig, Heiko⋅Konig, Heiko⋅Holyoake, Tessa L⋅Holyoake, Tessa L.⋅Bhatia, Ravi and Bhatia, RaviBlood, vol. 111, (no. 4), pp. 2329-2338, February 15, 2008.
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Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells.Konig, Heiko⋅Konig, Heiko⋅Copland, Mhairi⋅Copland, Mhairi⋅Chu, Su⋅Chu, Su⋅Jove, Richard⋅Jove, Richard⋅Holyoake, Tessa L⋅Holyoake, Tessa L⋅Bhatia, Ravi and Bhatia, RaviCancer research, vol. 68, (no. 23), pp. 9624-9633, December 1, 2008.
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Phospho-CRKL monitoring for the assessment of BCR-ABL activity in imatinib-resistant chronic myeloid leukemia or Ph+ acute lymphoblastic leukemia patients treated with nilotinibLa Rosee, Paul⋅Holm-Eriksen, Susanne⋅Konig, Heiko⋅Hartel, Nicolai⋅Ernst, Thomas⋅Debatin, Julia⋅Mueller, Martin⋅Erben, Philipp⋅Binckebanck, Anja⋅Wunderle, Lydia⋅Shou, Yaping⋅Dugan, Margaret⋅Hehlmann, Ruediger⋅Ottmann, Oliver and Hochhaus, AndreasHaematologica, vol. 93, (no. 5), pp. 769, 20080501.
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The Polyamide-Chlorambucil Conjugate 1R-Chl Effectively Inhibits Proliferation and Induces Apoptosis in CML Progenitor CellsKonig, Heiko⋅Chou, C. James⋅Gottesfeld, Joel M and Bhatia, RaviBlood, vol. 112, (no. 11), pp. 5031, 2008-11-16.
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2007
An international study to standardize the detection and quantitation of BCR-ABL transcripts from stabilized peripheral blood preparations by quantitative RT-PCRMuller, Martin⋅Müller, Martin C⋅Saglio, Guiseppe⋅Saglio, Giuseppe⋅Lin, Feng⋅Lin, Feng⋅Pfeifer, Heike⋅Pfeifer, Heike⋅Press, Rick D⋅Press, Richard⋅Tubbs, Raymond R⋅Tubbs, Raymond⋅Paschka, Peter⋅Paschka, Peter⋅Gottardi, Enrico⋅Gottardi, Enrico⋅O'Brien, Steven G⋅O'Brien, Steven⋅Ottmann, Oliver G⋅Ottmann, Oliver⋅Stockinger, Hubertus⋅Stockinger, Hubertus⋅Wieczorek, Lothar⋅Wieczorek, Lothar⋅Merx, Kirsten⋅Merx, Kirsten⋅Konig, Heiko⋅König, Heiko⋅Schwindel, Uwe⋅Schwindel, Uwe⋅Hehlmann, Rüdiger⋅Hehlmann, Rudiger⋅Hochhaus, Andreas and Hochhaus, AndreasHaematologica, vol. 92, (no. 7), pp. 973, 20070701.
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Effect of Dasatinib on BCR-ABL and Src Mediated Growth Signaling in Primary CML Hematopoietic ProgenitorsKonig, Heiko⋅Konig, Heiko⋅Copland, Mhairi⋅Copland, Mhairi⋅Jove, Richard⋅Jove, Richard⋅Holyoake, Tessa L⋅Holyoake, Tessa L.⋅Bhatia, Ravi and Bhatia, RaviBlood, vol. 110, (no. 11), pp. 2944, 2007-11-16.
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Enhanced Bcr-Abl-specific antileukemic activity of arsenic trioxide through glutathione-depletion in imatinib-resistant cellsKonig, Heiko⋅Konig, Heiko⋅Hartel, Nicolai⋅Härtel, Nicolai⋅Schultheis, Beate⋅Schultheis, Beate⋅Schatz, Michael⋅Schatz, Michael⋅Lorentz, Christian⋅Lorentz, Christian⋅Melo, Junia⋅Melo, Junia V⋅Hehlmann, Rüdiger⋅Hehlmann, Rudiger⋅Hochhaus, Andreas⋅Hochhaus, Andreas⋅La Rosee, Paul and La Rosée, PaulHaematologica, vol. 92, (no. 6), pp. 841, 20070601.
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MAPK-Activation in CD34+ CML Stem Cells Induced by Selective Abl-Inhibitors Is Not Observed Using the Combined Src/Abl-Inhibitor DasatinibLa Rosee, Paul⋅Haertel, Nicolai⋅Klag, Thomas⋅Konig, Heiko⋅Hehlmann, Ruediger and Hochhaus, AndreasBlood, vol. 110, (no. 11), pp. 652, 2007-11-16.
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Protection of CML Progenitors from Bcr-Abl Tyrosine Kinase Inhibitor Mediated Apoptosis by the Bone Marrow Stromal MicroenvironmentZhang, Bin⋅Zhang, Bin⋅Konig, Heiko⋅Konig, Heiko⋅Mcdonald, Tinisha⋅Mcdonald, Tinisha⋅Holyoake, Tessa L.⋅Holyoake, Tessa L⋅Campana, Dario⋅Campana, Dario⋅Bhatia, Ravi and Bhatia, RaviBlood, vol. 110, (no. 11), pp. 3378, 2007-11-16.
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Small Molecules Targeting Rad51 Recombinase Synergize with Imatinib and Overcome Imatinib-Resistance in CMLZhou, Longen⋅Zhou, Longen⋅Zhu, Jiewen⋅Zhu, Jiewen⋅Konig, Heiko⋅Konig, Heiko⋅Lin, Xiaoqin⋅Lin, Xiaoqin⋅Bhatia, Ravi⋅Bhatia, Ravi⋅Chamberlin, A. Richard⋅Chamberlin, A. Richard⋅Chen, Phang-Lang⋅Chen, Phang-Lang⋅Lee, Wen-Hwa and Lee, Wen-HwaBlood, vol. 110, (no. 11), pp. 466, 2007-11-16.
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