The Vilseck Laboratory is focused on the development and application of state-of-the-art computer simulations to provide atomistic insights into the mechanisms and thermodynamics of protein–ligand and protein–protein binding.
His research group will (i) continue to develop lambda dynamics-based computational techniques, (ii) apply these techniques to in silico structure-based drug design, and (iii) investigate aberrant protein side chain mutations in proliferative and infectious diseases to address on-going drug resistance.
