Our research focus is to investigate the noncoding RNA (ncRNA) regulatory network by G protein-coupled receptor-mediated signaling in heart failure using state-of-the-art cell approaches and mouse model systems. We are particularly interested in molecular mechanisms in downstream processes by which β-arrestin-mediated β-adrenergic receptor (βAR) signaling confers cardiac protection. Using active NIH & AHA grants, we investigate the roles of ncRNAs, a new class of gene regulators, in the βAR/β-arrestin-mediated cardioprotection. We also try to define the importance of βAR/β-arrestin-regulatable microRNAs (small ncRNAs) as well as their upstream regulators, long ncRNAs and their functional target genes in βAR-mediated β-arrestin cardioprotective pathways.
