We are particularly interested in the functions of the Mediator complex, a conserved, essential coactivator generally required for transcription by RNA Polymerase II (RNAPII).
We are investigating the mechanisms by which CTCF and BORIS influence transcription and chromatin architecture through these two classes of sites and are also exploring novel functions for CTCF and BORIS through mapping their protein-protein interaction landscapes.
My research focuses on genome-wide analysis of basal transcriptional regulation. I am also interested in the development and application of new technologies for genomic analysis of transcriptional regulation and the epigenome.
Skills and Expertise:
- Gene Regulation
- Molecular Biology
- Transcription Factors
- Gene Expression and Chromatin Biology
- Gene Expression
- epigenomic analysis of transcriptional regulation