23 Publications
2008
Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.
Chiesa, Roberto⋅Piccardo, Pedro⋅Biasini, Emiliano⋅Ghetti, Bernardino and Harris, David A
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 28, (no. 49), pp. 13258-67, 2008/Dec/3. | Journal Article
2007
Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice
Li, Aimin⋅Li, A.⋅Piccardo, Pedro⋅Piccardo, P.⋅Barmada, S.J.⋅Barmada, Sami J⋅Ghetti, B.⋅Ghetti, Bernardino⋅Harris, David A and Harris, D.A.
EMBO Journal, vol. 26, (no. 11), pp. 2777-2785, 2007. | Journal Article
2005
Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease
Chiesa, Roberto⋅Piccardo, Pedro⋅Dossena, Sara⋅Nowoslawski, Lisa⋅Roth, Kevin⋅Ghetti, Bernardino and Harris, David A
Proceedings of the National Academy of Sciences, USA, vol. 102, (no. 1), pp. 238-243, 2005. | Journal Article
2004
GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice
Barmada, Sami J⋅Barmada, S.⋅Piccardo, P.⋅Piccardo, Pedro⋅Yamaguchi, K.⋅Yamaguchi, Keiji⋅Ghetti, Bernardino⋅Ghetti, B.⋅Harris, D.A. and Harris, David A
Neurobiology of Disease, vol. 16, (no. 3), pp. 527-537, 2004. | Journal Article
2003
Molecular Distinction between Pathogenic and Infectious Properties of the Prion Protein
Chiesa, R.⋅Piccardo, Pedro⋅Quaglio, E.⋅Drisaldi, B.⋅Si-Hoe, SL⋅Takao, M.⋅Ghetti, Bernardino and Harris, David A
Journal of Virology, vol. 77, (no. 13), pp. 7611-7622, 2003. | Journal Article
 
Variable phenotype in a P102L Gerstmann-Sträussler-Scheinker Italian family.
De Michele, Giuseppe⋅Pocchiari, Maurizio⋅Petraroli, Rossella⋅Manfredi, Mario⋅Caneve, Giorgio⋅Coppola, Giovanni⋅Casali, Carlo⋅Saccà, Francesco⋅Piccardo, Pedro⋅Salvatore, Elena⋅Berardelli, Alfredo⋅Orio, Marcello⋅Barbieri, Fabrizio⋅Ghetti, Bernardino and Filla, Alessandro
The Canadian Journal of Neurological Sciences. Le Journal Canadien des Sciences Neurologiques, vol. 30, (no. 3), pp. 233-6, 2003/Aug. | Journal Article
2002
A novel mutation (G217D) in the Presenilin 1 gene ( PSEN1) in a Japanese family: presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum.
Takao, Masaki⋅Ghetti, Bernardino⋅Hayakawa, Isao⋅Ikeda, Eiji⋅Fukuuchi, Yasuo⋅Miravalle, Leticia⋅Piccardo, Pedro⋅Murrell, Jill R⋅Glazier, Bradley S and Koto, Atsuo
Acta neuropathologica, vol. 104, (no. 2), pp. 155-70, 2002/Aug. | Journal Article
 
Association between conformational mutations in neuroserpin and onset and severity of dementia.
Davis, Richard L⋅Shrimpton, Antony E⋅Carrell, Robin⋅Lomas, David⋅Gerhard, Lieselotte⋅Baumann, Bruno⋅Lawrence, Daniel A⋅Yepes, Manuel⋅Kim, Tai S⋅Ghetti, Bernardino⋅Piccardo, Pedro⋅Takao, Masaki⋅Lacbawan, Felicitas L⋅Muenke, Maximilian⋅Sifers, Richard N⋅Bradshaw, Charles B⋅Kent, Paul F⋅Collins, George H⋅Larocca, Daria and Holohan, Peter D
Lancet, vol. 359, (no. 9325), pp. 2242-7, 2002/Jun/29. | Journal Article
2001
A 7-kDa prion protein (PrP) fragment, an integral component of the PrP region required for infectivity, is the major amyloid protein in Gerstmann-Sträussler-Scheinker disease A117V.
Tagliavini, F⋅Lievens, P M⋅Tranchant, C⋅Warter, J M⋅Mohr, M⋅Giaccone, G⋅Perini, F⋅Rossi, G⋅Salmona, M⋅Piccardo, Pedro⋅Ghetti, Bernardino⋅Beavis, R C⋅Bugiani, O⋅Frangione, Blas and Prelli, F
The Journal of biological chemistry, vol. 276, (no. 8), pp. 6009-15, 2001/Feb/23. | Journal Article
 
Biochemical characterization of a neuroserpin variant associated with hereditary dementia.
Yazaki, M⋅Liepnieks, J J⋅Murrell, Jill R⋅Takao, M⋅Guenther, B⋅Piccardo, Pedro⋅Farlow, Martin R⋅Ghetti, Bernardino and Benson, Merrill D
The American journal of pathology, vol. 158, (no. 1), pp. 227-33, 2001/Jan. | Journal Article
 
Ectopic White Matter Neurons, a Developmental Abnormality That May Be Caused by the PSEN1 S169L Mutation in a Case of Familial AD with Myoclonus and Seizures
Takao, M.⋅Ghetti, Bernardino⋅Murrell, Jill R⋅Unverzagt, Frederick⋅Giaccone, G.⋅Tagliavini, F.⋅Bugiani, O.⋅Piccardo, Pedro⋅Hulette, Christine M⋅Crain, Barbara J⋅Farlow, Martin R and Heyman, Albert
Journal of Neuropathology & Experimental Neurology, vol. 60, (no. 12), pp. 1137-1152, 2001. | Journal Article
 
Prion proteins with different conformations accumulate in Gerstmann-Sträussler-Scheinker disease caused by A117V and F198S mutations.
Piccardo, Pedro⋅Piccardo, Pedro⋅Piccardo, Pedro⋅Piccardo, Pedro⋅Liepnieks, J J⋅Liepnieks, Juris J⋅Liepnieks, Juris J⋅Liepnieks, Juris J⋅William, A⋅William, Albert⋅William, Albert⋅William, Albert⋅Dlouhy, Stephen R⋅Dlouhy, Stephen R⋅Dlouhy, S R⋅Dlouhy, Stephen R⋅Farlow, Martin R⋅Farlow, M R⋅Farlow, Martin R⋅Farlow, Martin R⋅Young, Katherine⋅Young, K⋅Young, Katherine⋅Young, Katherine⋅Nochlin, David⋅Nochlin, David⋅Nochlin, David⋅Nochlin, David⋅Bird, Thomas D⋅Bird, Thomas D⋅Bird, Thomas D⋅Bird, T D⋅Nixon, Randal R⋅Nixon, Randal R⋅Nixon, Randal R⋅Nixon, R R⋅Ball, Melvyn J⋅Ball, M J⋅Ball, Melvyn J⋅Ball, Melvyn J⋅DeCarli, Charles⋅DeCarli, C⋅DeCarli, Charles⋅DeCarli, Charles⋅Bugiani, O⋅Bugiani, Orso⋅Bugiani, Orso⋅Bugiani, Orso⋅Tagliavini, Fabrizio⋅Tagliavini, Fabrizio⋅Tagliavini, F⋅Tagliavini, Fabrizio⋅Benson, Merrill D⋅Benson, Merrill D⋅Benson, Merrill D⋅Benson, M D⋅Ghetti, Bernardino⋅Ghetti, B⋅Ghetti, Bernardino and Ghetti, Bernardino
The American journal of pathology, vol. 158, (no. 6), pp. 2201-7, 2001/Jun. | Journal Article
2000
Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation
Chiesa, R.⋅Drisaldi, B.⋅Quaglio, E.⋅Migheli, A.⋅Piccardo, Pedro⋅Ghetti, Bernardino and Harris, David A
Proceedings of the National Academy of Sciences, USA, vol. 97, (no. 10), pp. 5580-5585, 2000. | Journal Article
 
Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation.
Chiesa, R⋅Drisaldi, B⋅Quaglio, E⋅Migheli, A⋅Piccardo, Pedro⋅Ghetti, Bernardino and Harris, David A
Proceedings of the National Academy of Sciences of the United States of America, vol. 97, (no. 10), pp. 5574-9, 2000/May/9. | Journal Article
 
Neuroserpin Mutation S52R Causes Neuroserpin Accumulation in Neurons and Is Associated with Progressive Myoclonus Epilepsy
Takao, M.⋅Benson, Merrill D⋅Murrell, Jill R⋅Yazaki, M.⋅Piccardo, Pedro⋅Unverzagt, Frederick⋅Davis, Robin L⋅Holohan, PD⋅Lawrence, Daniel A⋅Richardson, R.⋅Farlow, Martin R and Ghetti, Bernardino
Journal of Neuropathology & Experimental Neurology, vol. 59, (no. 12), pp. 1070-1086, 2000. | Journal Article
1998
Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues.
Jiménez-Huete, A⋅Lievens, P M⋅Vidal, Ruben G⋅Piccardo, Pedro⋅Ghetti, Bernardino⋅Tagliavini, F⋅Frangione, Blas and Prelli, F
The American journal of pathology, vol. 153, (no. 5), pp. 1561-72, 1998/Nov. | Journal Article
 
Neurological Illness in Transgenic Mice Expressing a Prion Protein with an Insertional Mutation
Chiesa, R.⋅Piccardo, Pedro⋅Ghetti, Bernardino and Harris, David A
Neuron, vol. 21, (no. 6), pp. 1339-1351, 1998. | Journal Article
 
Phenotypic variability of Gerstmann-Sträussler-Scheinker disease is associated with prion protein heterogeneity.
Piccardo, Pedro⋅Dlouhy, Stephen R⋅Lievens, P M⋅Young, K⋅Bird, Thomas D⋅Nochlin, David⋅Dickson, Dennis W⋅Vinters, Harry V⋅Zimmerman, T R⋅Mackenzie, Ian⋅Kish, S J⋅Ang, L C⋅De Carli, C⋅Pocchiari, M⋅Brown, P⋅Gibbs, C J⋅Gajdusek, D C⋅Bugiani, O⋅Ironside, J. W⋅Tagliavini, F and Ghetti, Bernardino
Journal of Neuropathology and Experimental Neurology, vol. 57, (no. 10), pp. 979-88, 1998/Oct. | Journal Article
1996
Prion protein hereditary amyloidosis: Parenchymal and vascular
Ghetti, Bernardino⋅Piccardo, Pedro⋅Frangione, Blas⋅Bugiani, O.⋅Giaccone, G.⋅Young, K.⋅Prelli, F.⋅Farlow, MR⋅Dlouhy, S. R and Tagliavini, F.
Seminars in Virology, vol. 7, (no. 3), pp. 189-200, 1996. | Journal Article
 
Proteinase-K-resistant prion protein isoforms in Gerstmann-Sträussler-Scheinker disease (Indiana kindred).
Piccardo, Pedro⋅Seiler, C⋅Dlouhy, Stephen R⋅Young, K⋅Farlow, Martin R⋅Prelli, F⋅Frangione, Blas⋅Bugiani, O⋅Tagliavini, F and Ghetti, Bernardino
Journal of neuropathology and experimental neurology, vol. 55, (no. 11), pp. 1157-63, 1996/Nov. | Journal Article
 
Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.
Ghetti, Bernardino⋅Piccardo, Pedro⋅Spillantini, Maria G⋅Ichimiya, Y⋅Porro, M⋅Perini, F⋅Kitamoto, Tetsuyuki⋅Tateishi, J⋅Seiler, C⋅Frangione, Blas⋅Bugiani, O⋅Giaccone, G⋅Prelli, F⋅Goedert, M⋅Dlouhy, Stephen R and Tagliavini, F
Proceedings of the National Academy of Sciences of the United States of America, vol. 93, (no. 2), pp. 744-8, 1996/Jan/23. | Journal Article
1995
Gerstmann-Sträussler-Scheinker disease (PRNP P102L): amyloid deposits are best recognized by antibodies directed to epitopes in PrP region 90-165.
Piccardo, Pedro⋅Ghetti, Bernardino⋅Dickson, Dennis W⋅Vinters, H V⋅Giaccone, G⋅Bugiani, O⋅Tagliavini, F⋅Young, K⋅Dlouhy, S R and Seiler, C
Journal of Neuropathology and Experimental Neurology, vol. 54, (no. 6), pp. 790-801, 1995/Nov. | Journal Article
 
Gerstmann-Sträussler-Scheinker disease with mutation at codon 102 and methionine at codon 129 of PRNP in previously unreported patients.
Young, K⋅Jones, C K⋅Piccardo, Pedro⋅Lazzarini, A⋅Golbe, Lawrence I⋅Zimmerman, T R⋅Dickson, Dennis W⋅McLachlan, D C⋅St George-Hyslop, P and Lennox, A
Neurology, vol. 45, (no. 6), pp. 1127-34, 1995/Jun. | Journal Article