Expertise

Research in my laboratory is centered on using three dimensional structure of proteins targets to design small molecules that modulate their function.

Our work currently focuses on the following classes of targets: urokinase-type plasminogen activator system, serine/threonine kinases, aldehyde dehydrogenases, and voltage-gated calcium channels. Compounds are identified through structure-based design that involves molecular docking and scoring.

I worked on understanding the mechanism by which β-lactamases hydrolyze β-lactam antibiotics.

 

 

 


Subject Area:

  • Biochemistry & Molecular Biology.

Expertise:

  • Pain Research
  • Spinal Cord and Brain Injury Research
Affiliations
Past Affiliations

Associate Professor, Stark Neurosciences Research Institute, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Assistant Professor, Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University (past)

Associate Professor, Department of Chemistry & Chemical Biology, School of Science, Indiana University-Purdue University Indianapolis

Assistant Professor, Department of Chemistry & Chemical Biology, School of Science, Indiana University-Purdue University Indianapolis

Communities
Biochemistry, Molecular Biology, Oncology, Cellular Biochemistry, Neuroscience, Molecular Biochemistry
Degrees
PhD, Wayne State University, Chemistry, 2001
BS, Wayne State University, Chemistry, 1995
Keywords
cancer or carcinogenesis infectious diseases or agents drug design biochemistry & molecular biology computational biology computational chemistry computer-aided design (cad)
Associations
American Chemical Society