My research is focused on the gap-junction protein Connexin43 (Cx43) as a regulator of intracellular signaling activated by therapeutic, hormonal and mechanical stimuli in osteocytes. A fundamental part of these investigations has been the generation and characterization of a genetically modified mouse model in which connexin43 has been deleted exclusively from osteocytes. Using this mouse model, I am studying the requirement of Cx43 for the survival of osteocytes and the effect of osteocyte apoptosis on bone formation and resorption.
Past Affiliations
PhD, University of Udine, Italy, Medical Sciences and Biotechnology, 2007
MS, University of Trieste, Italy, Biotechnology, 2003