24 Publications
2021
β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation.
Zhao, Wenxiu⋅Zhao, Wenxiu⋅Jiang, Lingxiang⋅Jiang, Lingxiang⋅Fang, Ting⋅Fang, Ting⋅Fang, Fei⋅Fang, Fei⋅Liu, Yingchun⋅Liu, Yingchun⋅Zhao, Ye⋅Zhao, Ye⋅You, Yuting⋅You, Yuting⋅Zhou, Hao⋅Zhou, Hao⋅Su, Xiaolin⋅Su, Xiaolin⋅Wang, Jiangwei⋅Wang, Jiangwei⋅Liu, Sheng⋅Liu, Sheng⋅Chen, Yaomin⋅Chen, Yaomin⋅Wan, Jun⋅Wan, Jun⋅Huang, Xiumei and Huang, Xiumei
Frontiers in oncology, vol. 11, pp. 747282, 2021. | Journal Article
2020
Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer.
Starcher, Colton L⋅Starcher, Colton L⋅Pay, S Louise⋅Pay, S. L⋅Singh, Naveen⋅Singh, Naveen⋅Yeh, I-Ju⋅Yeh, I-Ju⋅Bhandare, Snehal B⋅Bhandare, Snehal B⋅Su, Xiaolin⋅Su, Xiaolin⋅Huang, Xiumei⋅Huang, Xiumei⋅Bey, Erik A⋅Bey, Erik A⋅Motea, Edward A⋅Motea, Edward A⋅Boothman, David A and Boothman, David A
Frontiers in oncology, vol. 10, pp. 1575, 2020. | Journal Article
2019
NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers
Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Williams, Noelle S⋅Williams, Noelle S⋅Williams, Noelle S⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Gerber, David E⋅Gerber, David E⋅Gerber, David E⋅Beg, Muhammad S⋅Beg, Muhammad S⋅Beg, Muhammad S⋅Bey, Erik A⋅Bey, Erik A⋅Bey, Erik A⋅Boothman, David A⋅Boothman, David A and Boothman, David A
Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 25, (no. 8), pp. 2609, 2019-04-15. | Journal Article
 
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
Li, Xiaoguang⋅Li, Xiaoguang⋅Liu, Zhida⋅Liu, Zhida⋅Zhang, Anli⋅Zhang, Anli⋅Han, Chuanhui⋅Han, Chuanhui⋅Shen, Aijun⋅Shen, Aijun⋅Jiang, Lingxiang⋅Jiang, Lingxiang⋅Boothman, David A⋅Boothman, David A⋅Qiao, Jian⋅Qiao, Jian⋅Wang, Yang⋅Wang, Yang⋅Huang, Xiumei⋅Huang, Xiumei⋅Fu, Yang-Xin and Fu, Yang-Xin
Nature communications, vol. 10, (no. 1), pp. 13, 2019-07-19. | Journal Article
2018
Modulators of Redox Metabolism in Head and Neck Cancer.
Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Chen, Xiaofei⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Mims, Jade⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Singh, Naveen⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Motea, Edward⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Planchon, Sarah M⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Tsang, Allen W⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Porosnicu, Mercedes⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Kemp, Melissa L⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Furdui, Cristina M⋅Furdui, Cristina M⋅Furdui, Cristina M⋅Furdui, Cristina M⋅Furdui, Cristina M⋅Furdui, Cristina M and Furdui, Cristina M
Antioxidants & redox signaling, vol. 29, (no. 16), pp. 1660-1690, December 1, 2018. | Journal Article
2017
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
Beg, Muhammad Shaalan⋅Huang, Xiumei⋅Silvers, Molly A⋅Gerber, David E⋅Bolluyt, Joyce⋅Sarode, Venetia⋅Fattah, Farjana⋅Deberardinis, Ralph J⋅Merritt, Matthew E⋅Xie, Xian-Jin⋅Leff, Richard⋅Laheru, Daniel and Boothman, David A
Journal of surgical oncology, vol. 116, (no. 1), pp. 83-88, July 2017. | Journal Article
 
Using a novel NQO1 bioactivatable drug, beta‐lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer
MS, Beg⋅Beg, Muhammad Shaalan⋅Beg, Muhammad Shaalan⋅Huang, Xiumei⋅X, Huang⋅Huang, Xiumei⋅MA, Silvers⋅Silvers, Molly A⋅Silvers, Molly A⋅Gerber, David E⋅DE, Gerber⋅Gerber, David E⋅Bolluyt, Joyce⋅Bolluyt, Joyce⋅J, Bolluyt⋅V, Sarode⋅Sarode, Venetia⋅Sarode, Venetia⋅Fattah, Farjana⋅Fattah, Farjana⋅F, Fattah⋅Deberardinis, Ralph J⋅Deberardinis, Ralph J⋅RJ, Deberardinis⋅Me, Merritt⋅Merritt, Matthew E⋅Merritt, Matthew E⋅Xie, Xian‐Jin⋅XJ, Xie⋅Xie, Xian‐Jin⋅Leff, Richard⋅Leff, Richard⋅R, Leff⋅Laheru, Daniel⋅Laheru, Daniel⋅D, Laheru⋅DA, Boothman⋅Boothman, David A and Boothman, David A
Journal of Surgical Oncology, vol. 116, (no. 1), pp. 88, July 1, 2017. | Journal Article
2016
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors
Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Motea, Edward A⋅Moore, Zachary R⋅Moore, Zachary R⋅Moore, Zachary R⋅Moore, Zachary R⋅Yao, Jun⋅Yao, Jun⋅Yao, Jun⋅Yao, Jun⋅Dong, Ying⋅Dong, Ying⋅Dong, Ying⋅Dong, Ying⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Silvers, Molly A⋅Silvers, Molly A⋅Silvers, Molly A⋅Silvers, Molly A⋅Patidar, Praveen L⋅Patidar, Praveen L⋅Patidar, Praveen L⋅Patidar, Praveen L⋅Cholka, Agnieszka⋅Cholka, Agnieszka⋅Cholka, Agnieszka⋅Cholka, Agnieszka⋅Fattah, Farjana⋅Fattah, Farjana⋅Fattah, Farjana⋅Fattah, Farjana⋅Cha, Yoonjeong⋅Cha, Yoonjeong⋅Cha, Yoonjeong⋅Cha, Yoonjeong⋅Anderson, Glenda G⋅Anderson, Glenda G⋅Anderson, Glenda G⋅Anderson, Glenda G⋅Kusko, Rebecca⋅Kusko, Rebecca⋅Kusko, Rebecca⋅Kusko, Rebecca⋅Peyton, Michael⋅Peyton, Michael⋅Peyton, Michael⋅Peyton, Michael⋅Yan, Jingsheng⋅Yan, Jingsheng⋅Yan, Jingsheng⋅Yan, Jingsheng⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Xie, Xian-Jin⋅Sarode, Venetia⋅Sarode, Venetia⋅Sarode, Venetia⋅Sarode, Venetia⋅Williams, Noelle S⋅Williams, Noelle S⋅Williams, Noelle S⋅Williams, Noelle S⋅Minna, John D⋅Minna, John D⋅Minna, John D⋅Minna, John D⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Beg, Muhammad⋅Gerber, David E⋅Gerber, David E⋅Gerber, David E⋅Gerber, David E⋅Bey, Erik A⋅Bey, Erik A⋅Bey, Erik A⋅Bey, Erik A⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A and Boothman, David A
Cancer Cell, vol. 30, (no. 6), pp. 952, 2016-12-12. | Journal Article
2015
Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy
Ma, Xinpeng⋅Ma, Xinpeng⋅Ma, Xinpeng⋅Huang, Xiumei⋅Huang, Gang⋅Huang, Xiumei⋅Huang, Xiumei⋅Moore, Zachary⋅Moore, Zachary⋅Moore, Zachary⋅Huang, Gang⋅Huang, Gang⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Wang, Yiguang⋅Wang, Yiguang⋅Wang, Yiguang⋅Hammer, Suntrea⋅Hammer, Suntrea⋅Hammer, Suntrea⋅Williams, Noelle S⋅Williams, Noelle S⋅Williams, Noelle S⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Gao, Jinming⋅Gao, Jinming and Gao, Jinming
Journal of Controlled Release, vol. 200, pp. 211, 2015-02-28. | Journal Article
 
Molecular classification and drug resistance analysis of Escherichia coli isolated from poultry in China
Gai, Wenyan⋅Wang, Junwei⋅Wang, Juan⋅Cui, Zhigang⋅Qu, Zhina⋅Cui, Jinghua⋅Du, Xiaoli⋅Huang, Xiumei and Zhao, Jianmei
International journal of clinical and experimental medicine, vol. 8, (no. 1), pp. 844, 2015-00-00. | Journal Article
 
Nanotechnology-enabled delivery of NQO1 bioactivatable drugs.
Ma, Xinpeng⋅Ma, Xinpeng⋅Ma, Xinpeng⋅Moore, Zachary R⋅Moore, Zachary R⋅Moore, Zachary R⋅Huang, Gang⋅Huang, Gang⋅Huang, Gang⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Boothman, David A⋅Boothman, David A⋅Boothman, David A⋅Gao, Jinming⋅Gao, Jinming and Gao, Jinming
Journal of drug targeting, vol. 23, (no. 7-8), pp. 672-680, 2015. | Journal Article
2014
Abstract 787: DNA repair and metabolism inhibitors are tumor-selective when combined with NQO1 bioactivatable drugs for therapy against pancreatic and nonsmall cell lung cancers
Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Moore, Zachary⋅Moore, Zachary⋅Moore, Zachary⋅Luo, Xiuquan⋅Luo, Xiuquan⋅Luo, Xiuquan⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Chakrabarti, Gaurab⋅Ilcheva, Mariya⋅Ilcheva, Mariya⋅Ilcheva, Mariya⋅Brekken, Rolf⋅Brekken, Rolf⋅Brekken, Rolf⋅Burma, Sandeep⋅Burma, Sandeep⋅Burma, Sandeep⋅Gao, Jinming⋅Gao, Jinming⋅Gao, Jinming⋅Deberardinis, Ralph⋅Deberardinis, Ralph⋅Deberardinis, Ralph⋅Bornmann, William⋅Bornmann, William⋅Bornmann, William⋅Hergenrother, Paul⋅Hergenrother, Paul⋅Hergenrother, Paul⋅Boothman, David A⋅Boothman, David A and Boothman, David A
Cancer Research, vol. 74, (no. 19 Supplement), pp. 787, 2014-10-01. | Journal Article
 
Prodrug Strategy to Achieve Lyophilizable, High Drug Loading Micelle Formulations Through Diester Derivatives of [beta]-Lapachone
Ma, Xinpeng⋅Ma, Xinpeng⋅Ma, Xinpeng⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Xiumei⋅Huang, Gang⋅Huang, Gang⋅Huang, Gang⋅Li, Longshan⋅Li, Longshan⋅Li, Longshan⋅Wang, Yiguang⋅Wang, Yiguang⋅Wang, Yiguang⋅Luo, Xiuquan⋅Luo, Xiuquan⋅Luo, Xiuquan⋅Boothman, David A⋅Boothman, David A⋅Boothman, David⋅Gao, Jinming⋅Gao, Jinming and Gao, Jinming
Advanced Healthcare Materials, vol. 3, (no. 8), pp. 1210, 20140801. | Journal Article
2013
Abstract 3344: Inhibiting base excision repair synergistically enhances beta-lapachone-mediated ‘kiss of death’ for tumor-selective therapy of pancreatic cancer
Luo, Xiuquan⋅Luo, Xiuquan⋅Li, Longshan⋅Li, Longshan⋅Huang, Xiumei⋅Huang, Xiumei⋅Cao, Lifen⋅Cao, Lifen⋅Moore, Zachary⋅Moore, Zachary⋅Deberardinis, Ralph⋅Deberardinis, Ralph⋅Brekken, Rolf⋅Brekken, Rolf⋅Gerson, Stanton⋅Gerson, Stanton⋅Liu, Lili⋅Liu, Lili⋅Boothman, David A and Boothman, David A
Cancer Research, vol. 73, (no. 8 Supplement), pp. 3344, 2013-04-15. | Journal Article
2012
Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid
Chen, Yaomin⋅Chen, Yaomin⋅Huang, Xiumei⋅Huang, Xiumei⋅Zhang, Yun-wu⋅Zhang, Yun-wu⋅Rockenstein, Edward⋅Rockenstein, Edward⋅Bu, Guojun⋅Bu, Guojun⋅Golde, Todd E⋅Golde, Todd E⋅Masliah, Eliezer⋅Masliah, Eliezer⋅Xu, Huaxi and Xu, Huaxi
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 32, (no. 33), pp. 11395, 2012-Aug-15. | Journal Article
 
An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis
Huang, Xiumei⋅HUANG, XIUMEI⋅Huang, Xiumei⋅Huang, Xiumei⋅DONG, YING⋅Dong, Ying⋅Dong, Ying⋅Dong, Ying⋅Bey, Erik A⋅GAO, JINMING⋅Bey, Erik A⋅Bey, Erik A⋅HERGENROTHER, Paul J⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Kilgore, Jessica A⋅Bair, Joseph S⋅BOOTHMAN, David A⋅Bair, Joseph S⋅Bair, Joseph S⋅Li, Long-Shan⋅Li, Long-Shan⋅BEY, Erik A⋅Li, Long-Shan⋅KILGORE, Jessica A⋅Patel, Malina⋅Patel, Malina⋅Patel, Malina⋅Parkinson, Elizabeth I⋅Parkinson, Elizabeth I⋅BAIR, Joseph S⋅Parkinson, Elizabeth I⋅Wang, Yiguang⋅LI, Long-Shan⋅Wang, Yiguang⋅Wang, Yiguang⋅Williams, Noelle S⋅Williams, Noelle S⋅Williams, Noelle S⋅PATES, Malina⋅Parkinson, Elizabeth I⋅Gao, Jinming⋅Gao, Jinming⋅Gao, Jinming⋅Hergenrother, Paul J⋅Hergenrother, Paul J⋅WANG, YIGUANG⋅Hergenrother, Paul J⋅Boothman, David⋅WILLIAMS, Noelle S⋅Boothman, David A and Boothman, David A
Cancer research, vol. 72, (no. 12), pp. 3047, 2012-Jun-15. | Journal Article
 
Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration
Zhang, Han⋅Zhang, Han⋅Zhang, Yun-wu⋅Zhang, Yun-wu⋅Chen, Yaomin⋅Chen, Yaomin⋅Huang, Xiumei⋅Huang, Xiumei⋅Zhou, Fangfang⋅Zhou, Fangfang⋅Wang, Weiwei⋅Wang, Weiwei⋅Xian, Bo⋅Xian, Bo⋅Zhang, Xian⋅Zhang, Xian⋅Masliah, Eliezer⋅Masliah, Eliezer⋅Chen, Quan⋅Chen, Quan⋅Han, Jing-Dong J⋅Han, Jing-Dong J⋅Bu, Guojun⋅Bu, Guojun⋅Reed, John C⋅Reed, John C⋅Liao, Francesca Fang⋅Liao, Francesca-Fang⋅Chen, Ye-Guang⋅Chen, Ye-Guang⋅Xu, Huaxi and Xu, Huaxi
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 32, (no. 44), pp. 15576, 2012-Oct-31. | Journal Article
 
Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway
Huang, Xiumei⋅Chen, Yaomin⋅Zhang, Han⋅Ma, Qilin⋅Zhang, Yun-wu and Xu, Huaxi
Neurobiology of Aging, vol. 33, (no. 5), pp. 1007.e17, 2012. | Journal Article
2010
A Protease‐Based Strategy for the Controlled Release of Therapeutic Peptides
Li, Hongjian⋅Ma, Yi⋅Chen, Ying⋅Sang, Yanxia⋅Zhou, Tianhong⋅Qiu, Meilan⋅Huang, Xiumei⋅Zhou, Cindy and Su, Zhengding
Angewandte Chemie International Edition, vol. 49, (no. 29), pp. 4933, July 5, 2010. | Journal Article
 
P2‐213: Appoptosin interacts with amyloid precursor protein and mediates neuronal toxicity via caspase depended pathway
Zhang, Han⋅Zhang, Yunwu⋅Huang, Xiumei⋅Chen, Yaomin and Xu, Huaxi
Alzheimer's & Dementia, vol. 6, pp. S376, July 2010. | Journal Article
 
P2‐312: The Rps23r1 gene family regulates Alzheimer's beta‐amyloid generation and tau phosphorylation
Zhang, Yunwu⋅Huang, Xiumei⋅Chen, Yaomin⋅Liao, Francesca-Fang⋅Li, Limin and Xu, Huaxi
Alzheimer's & Dementia, vol. 6, pp. S405, July 2010. | Journal Article
 
The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation
Huang, Xiumei⋅Huang, Xiumei⋅Chen, Yaomin⋅Chen, Yaomin⋅Li, Wu-Bo⋅Li, Wu-Bo⋅Cohen, Stanley N⋅Cohen, Stanley N⋅Liao, Francesca-Fang⋅Liao, Francesca Fang⋅Li, Limin⋅Li, Limin⋅Xu, Huaxi⋅Xu, Huaxi⋅Zhang, Yun-Wu and Zhang, Yun-Wu
Human molecular genetics, vol. 19, (no. 19), pp. 3843, 2010-Oct-01. | Journal Article
2009
A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's β-Amyloid Levels and Tau Phosphorylation
Zhang, Yun-wu⋅Zhang, Yun-wu⋅Liu, Shijie⋅Liu, Shijie⋅Zhang, Xue⋅Zhang, Xue⋅Li, Wu-Bo⋅Li, Wu-Bo⋅Chen, Yaomin⋅Chen, Yaomin⋅Huang, Xiumei⋅Huang, Xiumei⋅Sun, Liangwu⋅Sun, Liangwu⋅Luo, Wenjie⋅Luo, Wenjie⋅Netzer, William J⋅Netzer, William J⋅Threadgill, Richard⋅Threadgill, Richard⋅Wiegand, Gordon⋅Wiegand, Gordon⋅Wang, Ruishan⋅Wang, Ruishan⋅Cohen, Stanley N⋅Cohen, Stanley N⋅Greengard, Paul⋅Greengard, Paul⋅Liao, Francesca Fang⋅Liao, Francesca-Fang⋅Li, Limin⋅Li, Limin⋅Xu, Huaxi and Xu, Huaxi
Neuron, vol. 64, (no. 3), pp. 340, 2009. | Journal Article
 
Retinoid X receptor-[alpha] mediates -flurbiprofen's effect on the levels of Alzheimer's [beta]-amyloid
You, Xiaoqing⋅Zhang, Yun-wu⋅Chen, Yaomin⋅Huang, Xiumei⋅Xu, Raymond⋅Cao, Xihua⋅Chen, Jiebo⋅Liu, Yun⋅Zhang, Xiaokun and Xu, Huaxi
Journal of Neurochemistry, vol. 111, (no. 1), pp. 142, 20091001. | Journal Article