24 Publications
2022
Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion.
Yan, Shijun⋅Yan, Shijun⋅Conley, Jason M⋅Conley, Jason M⋅Reilly, Austin M⋅Reilly, Austin M⋅Stull, Natalie D⋅Stull, Natalie D⋅Abhyankar, Surabhi D⋅Abhyankar, Surabhi D⋅Ericsson, Aaron C⋅Ericsson, Aaron C⋅Kono, Tatsuyoshi⋅Kono, Tatsuyoshi⋅Molosh, Andrei I⋅Molosh, Andrei I⋅Kubal, Chandrashekhar A⋅Kubal, Chandrashekhar A⋅Evans-Molina, Carmella⋅Evans-Molina, Carmella⋅Ren, Hongxia and Ren, Hongxia
Cell reports, vol. 38, (no. 1), pp. 110179, January 4, 2022. | Journal Article
2021
Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles
Conley, Jason M.⋅Sun, Hongmao⋅Ayers, Kristin L.⋅Zhu, Hu⋅Chen, Rong⋅Shen, Min⋅Hall, Matthew D. and Ren, Hongxia
Journal of Biological Chemistry, pp. 100881. | Journal Article
2020
Metabolic Defects Caused by High-Fat Diet Modify Disease Risk through Inflammatory and Amyloidogenic Pathways in a Mouse Model of Alzheimer’s Disease
Reilly, Austin M.⋅Tsai, Andy P.⋅Lin, Peter B.⋅Ericsson, Aaron C.⋅Oblak, Adrian L. and Ren, Hongxia
Nutrients, vol. 12, pp. 2977. | Journal Article
2019
Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-Expressing Neurons
Ren, Hongxia⋅Vieira-de-Abreu, Adriana⋅Yan, Shijun⋅Reilly, Austin M⋅Chan, Owen and Accili, Domenico
Endocrinology, vol. 160, (no. 9), pp. 2038-2048, Sep 2019. | Journal Article
 
Correction to: Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits
Glicksberg, B.S.⋅Glicksberg, Benjamin S⋅Amadori, L.⋅Amadori, Letizia⋅Akers, Nicholas K⋅Akers, N.K.⋅Sukhavasi, K.⋅Sukhavasi, Katyayani⋅Franzén, Oscar⋅Franzén, O.⋅Li, L.⋅Li, Li⋅Belbin, Gillian M⋅Belbin, G.M.⋅Akers, K.L.⋅Ayers, Kristin L⋅Shameer, Khader⋅Shameer, K.⋅Badgeley, M.A.⋅Badgeley, Marcus A⋅Johnson, Kipp W⋅Johnson, K.W.⋅Readhead, Ben⋅Readhead, B.⋅Darrow, B.J.⋅Darrow, Bruce J⋅Kenny, Eimear E⋅Kenny, E.E.⋅Betsholtz, C.⋅Betsholtz, Christer⋅Ermel, Raili⋅Ermel, R.⋅Skogsberg, J.⋅Skogsberg, Josefin⋅Ruusalepp, A.⋅Ruusalepp, Arno⋅Schadt, E.E.⋅Schadt, Eric E⋅Dudley, Joel T⋅Dudley, J.T.⋅Ren, Hongxia⋅Ren, H.⋅Kovacic, Jason C⋅Kovacic, J.C.⋅Giannarelli, C.⋅Giannarelli, Chiara⋅Li, Shuyu D⋅Li, S.D.⋅Björkegren, Johan L. M⋅Björkegren, J.L.M.⋅Chen, R. and Chen, Rong
BMC Medical Genomics, vol. 12, (no. 1), pp. 154, 2019-12-00. | Journal Article
 
Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding
Reilly, Austin M⋅Reilly, Austin M⋅Zhou, Shudi⋅Zhou, Shudi⋅Panigrahi, Sunil K⋅Panigrahi, Sunil K⋅Yan, Shijun⋅Yan, Shijun⋅Conley, Jason M⋅Conley, Jason M⋅Sheets, Patrick L⋅Sheets, Patrick L⋅Wardlaw, Sharon L⋅Wardlaw, Sharon L⋅Ren, Hongxia and Ren, Hongxia
Nutrition & Diabetes, vol. 9, (no. 1), 2019-12-00. | Journal Article
 
Gpr17 signaling decreases GLP-1 secretion in GLUTag cells
Stalbaum, Katherine⋅Yan, Shijun and Ren, Hongxia
Proceedings of IMPRS, vol. 2, (no. 1), 2019-10-09. | Journal Article
2018
Type 2 Diabetes Mouse Model: Insights into the Contribution of Metabolic Defects to Neurocognitive Decline
Loncharich, Alexa⋅Reilly, Austin⋅Yan, Shijun and Ren, Hongxia
Proceedings of IMPRS, vol. 1, (no. 1), 2018-12-07. | Journal Article
2015
Anorexia and Impaired Glucose Metabolism in Mice With Hypothalamic Ablation of Glut4 Neurons
Ren, Hongxia⋅Ren, Hongxia⋅Lu, Taylor Y⋅Lu, Taylor Y⋅McGraw, Timothy E⋅Mc Graw, Timothy E⋅Accili, Domenico and Accili, Domenico
Diabetes, vol. 64, (no. 2), pp. 417, 2015-Feb. | Journal Article
 
Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin
Ren, Hongxia⋅Cook, Joshua R⋅Kon, Ning and Accili, Domenico
Diabetes, vol. 64, (no. 11), pp. 3679, 2015-Nov. | Journal Article
2014
Glut4 expression defines an insulin-sensitive hypothalamic neuronal population
Ren, Hongxia⋅Ren, Hongxia⋅Yan, Shijun⋅Yan, Shijun⋅Zhang, Baifang⋅Zhang, Baifang⋅Lu, Taylor⋅Lu, Taylor Y⋅Arancio, Ottavio⋅Arancio, Ottavio⋅Accili, Domenico and Accili, Domenico
Molecular Metabolism, vol. 3, (no. 4), pp. 459, 2014. | Journal Article
2013
Blunted Refeeding Response and Increased Locomotor Activity in Mice Lacking FoxO1 in Synapsin-Cre-Expressing Neurons
Ren, Hongxia⋅Ren, Hongxia⋅Plum-Morschel, Leona⋅Plum-Morschel, Leona⋅Gutierrez Juarez, Roger⋅Gutierrez-Juarez, Roger⋅Lu, Taylor Y⋅Lu, Taylor Y⋅Kim-Muller, Ja Young⋅Kim-Muller, Ja Y⋅Heinrich, Garrett⋅Heinrich, Garrett⋅Wardlaw, Sharon L⋅Wardlaw, Sharon L⋅Silver, Rae⋅Silver, Rae⋅Accili, Domenico and Accili, Domenico
Diabetes, vol. 62, (no. 10), pp. 3383, 2013-Oct. | Journal Article
 
Common genetic variants regulating ADD3 gene expression alter biliary atresia risk
Cheng, Guo⋅Cheng, Guo⋅Tang, Clara⋅Tang, Clara S⋅Wong, Emily H⋅Wong, Emily⋅Cheng, William W⋅Cheng, William⋅So, Man-Ting⋅So, Man-Ting⋅Miao, Xiaoping⋅Miao, Xiaoping⋅Zhang, Ruizhong⋅Zhang, Ruizhong⋅Cui, Long⋅Cui, Long⋅Liu, Xuelai⋅Liu, Xuelai⋅Ngan, Elly⋅Ngan, Elly S⋅Lui, Vincent C⋅Lui, Vincent⋅Chung, Patrick H⋅Chung, Patrick⋅Chan, Ivy⋅Chan, Ivy H⋅Liu, Juncheng⋅Liu, Juncheng⋅Zhong, Wei⋅Zhong, Wei⋅Xia, Huimin⋅Xia, Huimin⋅Yu, Jiakang⋅Yu, Jiakang⋅Qiu, Xiu⋅Qiu, Xiu⋅Wu, Xuan-Zhao⋅Wu, Xuan-Zhao⋅Wang, Bin⋅Wang, Bin⋅Dong, Xiao⋅Dong, Xiao⋅Tou, Jinfa⋅Tou, Jinfa⋅Huang, Liuming⋅Huang, Liuming⋅Yi, Bin⋅Yi, Bin⋅Ren, Hongxia⋅Ren, Hongxia⋅Chan, Edwin⋅Chan, Edwin K⋅Ye, Kenny⋅Ye, Kenny⋅O′Reilly, Paul⋅O'Reilly, Paul F⋅Wong, Kenneth⋅Wong, Kenneth K⋅Sham, Pak Chung⋅Sham, Pak-Chung⋅Cherny, Stacey S⋅Cherny, Stacey⋅Tam, Paul⋅Tam, Paul K⋅Garcia-Barceló, Maria-Mercè and Garcia-Barceló, Maria-Mercè
Journal of Hepatology, vol. 59, (no. 6), pp. 1291, 2013. | Journal Article
 
Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells
Jiao, Shuang⋅Jiao, Shuang⋅Jiao, Shuang⋅Ren, Hongxia⋅Ren, Hongxia⋅Ren, Hongxia⋅Li, Yun⋅Li, Yun⋅Li, Yun⋅Zhou, Jianfeng⋅Zhou, Jianfeng⋅Zhou, Jianfeng⋅Duan, Cunming⋅Duan, Cunming⋅Duan, Cunming⋅Lu, Ling⋅Lu, Ling and Lu, Ling
Molecular and Cellular Biochemistry, vol. 373, (no. 1), pp. 113, 20130100. | Journal Article
 
FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake
Ren, Hongxia⋅Orozco, Ian J⋅Su, Ya⋅Suyama, Shigetomo⋅Gutiérrez-Juárez, Roger⋅Horvath, Tamas L⋅Wardlaw, Sharon L⋅Plum, Leona⋅Arancio, Ottavio and Accili, Domenico
Cell, vol. 153, (no. 5), pp. 1166, 2013-05-23. | Journal Article
2012
Controllable ring‐opening copolymerization of L‐lactide and (3S)‐benzyloxymethyl‐(6S)‐methyl‐morpholine‐2,5‐dione initiated by a biogenic compound creatinine acetate
Pang, Zibo⋅Li, Hong⋅He, Peiru⋅Wang, Yuqin⋅Ren, Hongxia⋅Wang, Hao and Zhu, X.X
Journal of Polymer Science Part A: Polymer Chemistry, vol. 50, (no. 19), pp. 4009, 1 October 2012. | Journal Article
 
FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake
Ren, Hongxia⋅Ren, Hongxia⋅Orozco, Ian J⋅Orozco, Ian J⋅Su, Ya⋅Su, Ya⋅Suyama, Shigetomo⋅Suyama, Shigetomo⋅Gutiérrez-Juárez, Roger⋅Gutierrez Juarez, Roger⋅Horvath, Tamas L⋅Horvath, Tamas L⋅Wardlaw, Sharon L⋅Wardlaw, Sharon L⋅Plum, Leona⋅Plum, Leona⋅Arancio, Ottavio⋅Arancio, Ottavio⋅Accili, Domenico and Accili, Domenico
Cell, vol. 149, (no. 6), pp. 1326, 2012-06-08. | Journal Article
2011
Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues
Lin, Hua V⋅Lin, Hua V⋅Ren, Hongxia⋅Ren, Hongxia⋅Samuel, Varman T⋅Samuel, Varman T⋅Lee, Hui-Young⋅Lee, Hui-Young⋅Lu, Taylor Y⋅Lu, Taylor Y⋅Shulman, Gerald I⋅Shulman, Gerald I⋅Accili, Domenico and Accili, Domenico
Diabetes, vol. 60, (no. 3), pp. 709, 2011-Mar. | Journal Article
2010
Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways
Ren, Hongxia⋅Ren, Hongxia⋅Accili, Domenico⋅Accili, Domenico⋅Duan, Cunming⋅Duan, Cunming and Semenza, Gregg
Proceedings of the National Academy of Sciences of the United States of America, vol. 107, (no. 13), pp. 5862, 20100330. | Journal Article
 
Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: Roles in skeletal muscle growth and differentiation
Duan, Cunming⋅Duan, Cunming⋅Ren, Hongxia⋅Ren, Hongxia⋅Gao, Shan and Gao, Shan
General and Comparative Endocrinology, vol. 167, (no. 3), pp. 351, 2010. | Journal Article
2008
IGFBP-5 Regulates Muscle Cell Differentiation by Binding to IGF-II and Switching on the IGF-II Auto-Regulation Loop
Ren, Hongxia⋅Ren, Hongxia⋅Yin, Ping⋅Yin, Ping⋅Duan, Cunming and Duan, Cunming
The Journal of Cell Biology, vol. 182, (no. 5), pp. 991, 20080908. | Journal Article
2006
OR03-6 HYPOXIA INHIBITS MUSCLE DIFFERENTIATION BY DOWN-REGULATING THE IGF SIGNALING PATHWAY THROUGH A HIF-DEPENDENT MECHANISM
Ren, Hongxia and Duan, Cunming
Growth Hormone & IGF Research, vol. 16, pp. S6, 2006. | Journal Article
2004
Dynamic Tracking of Acute Ischemic Tissue Fates Using Improved Unsupervised ISODATA Analysis of High-Resolution Quantitative Perfusion and Diffusion Data
Shen, Qiang⋅Shen, Qiang⋅Ren, Hongxia⋅Ren, Hongxia⋅Fisher, Marc⋅Fisher, Marc⋅Bouley, James⋅Bouley, James⋅Duong, Timothy Q and Duong, Timothy Q
Journal of Cerebral Blood Flow & Metabolism, vol. 24, (no. 8), pp. 897, 2004-08-00. | Journal Article
 
Partial‐volume effect on ischemic tissue‐fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model
Ren, Hongxia⋅Ren, Hongxia⋅Shen, Qiang⋅Shen, Qiang⋅Bardutzky, Juergen⋅Bardutzky, Juergen⋅Fisher, Marc⋅Fisher, Marc⋅Duong, Timothy Q and Duong, Timothy Q
Magnetic Resonance in Medicine, vol. 52, (no. 6), pp. 1335, December 2004. | Journal Article