42 Publications (Page 1 of 2)
2022
A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer. Cancers
 
Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.
S, Chitre⋅AM, Ray⋅M, Stevens⋅EH, Doud⋅H, Liechty⋅A, Washburn⋅K, Tepper⋅J, Sivinski⋅HM, O’Hagan⋅MM, Georgiadis⋅E, Chapman and SM, Johnson
Bioorganic & medicinal chemistry. | Journal Article
 
Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene.
Allen, Jawara⋅Rosendahl Huber, Axel⋅Pleguezuelos-Manzano, Cayetano⋅Puschhof, Jens⋅Wu, Shaoguang⋅Wu, Xinqun⋅Boot, Charelle⋅Saftien, Aurelia⋅O'Hagan, Heather M⋅Wang, Hao⋅van Boxtel, Ruben⋅Clevers, Hans and Sears, Cynthia L
Microbiology spectrum. | Journal Article
 
Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer.
Journal of translational medicine. | Journal Article
 
Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatment.
S, Sriramkumar⋅TX, Metcalfe⋅T, Lai⋅X, Zong⋅F, Fang⋅HM, O’Hagan and KP, Nephew
PloS one. | Journal Article
2021
Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy.
DeStefano Shields, Christina E⋅DeStefano Shields, Christina E⋅White, James R⋅White, James R⋅Chung, Liam⋅Chung, Liam⋅Wenzel, Alyssa⋅Wenzel, Alyssa⋅Hicks, Jessica L⋅Hicks, Jessica L⋅Tam, Ada J⋅Tam, Ada J⋅Chan, June L⋅Chan, June L⋅Dejea, Christine M⋅Dejea, Christine M⋅Fan, Hongni⋅Fan, Hongni⋅Michel, John⋅Michel, John⋅Maiuri, Ashley R⋅Maiuri, Ashley R⋅Sriramkumar, Shruthi⋅Sriramkumar, Shruthi⋅Podicheti, Ram⋅Podicheti, Ram⋅Rusch, Douglas B⋅Rusch, Douglas B⋅Wang, Hao⋅Wang, Hao⋅De Marzo, Angelo M⋅De Marzo, Angelo M⋅Besharati, Sepideh⋅Besharati, Sepideh⋅Anders, Robert A⋅Anders, Robert A⋅Baylin, Stephen B⋅Baylin, Stephen B⋅O'Hagan, Heather M⋅O'Hagan, Heather M⋅Housseau, Franck⋅Housseau, Franck⋅Sears, Cynthia L and Sears, Cynthia L
Cancer discovery. | Journal Article
 
Consensus molecular subtyping of colorectal cancers is influenced by goblet cell content.
Cancer genetics. | Journal Article
 
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.
Ray, Anne-Marie⋅Salim, Nilshad⋅Stevens, Mckayla⋅Chitre, Siddhi⋅Abdeen, Sanofar⋅Washburn, Alex⋅Sivinski, Jared⋅O'Hagan, Heather M⋅Chapman, Eli and Johnson, Steven M
Bioorganic & medicinal chemistry. | Journal Article
 
How Epigenetic Therapy Beats Adverse Genetics in Monosomy Karyotype AML.
Cancer research. | Journal Article
 
LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support BRAF-Mutant Colorectal Cancer.
Cancer research. | Journal Article
2020
Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer.
Sriramkumar, Shruthi⋅S, Sriramkumar⋅TD, Matthews⋅Matthews, Timothy D.⋅AH, Ghobashi⋅Ghobashi, Ahmed H.⋅Miller, Samuel A.⋅SA, Miller⋅VanderVere-Carozza, Pamela S.⋅PS, VanderVere-Carozza⋅KS, Pawelczak⋅Pawelczak, Katherine S.⋅Nephew, Kenneth P.⋅KP, Nephew⋅JJ, Turchi⋅Turchi, John J⋅O’Hagan, Heather M. and HM, O’Hagan
Molecular cancer research : MCR. | Journal Article
2019
Dietary antioxidants remodel DNA methylation patterns in chronic disease.
Beetch, Megan⋅M, Beetch⋅S, Harandi-Zadeh⋅Harandi-Zadeh, Sadaf⋅K, Shen⋅Shen, Kate⋅K, Lubecka⋅Lubecka, Katarzyna⋅Kitts, David D⋅DD, Kitts⋅HM, O’Hagan⋅O'Hagan, Heather M⋅Stefanska, Barbara and B, Stefanska
British journal of pharmacology. | Journal Article
 
DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis.
AR, Maiuri⋅SS, Savant⋅R, Podicheti⋅DB, Rusch and HM, O’Hagan
Epigenetics. | Journal Article
 
JAK2 regulates mismatch repair protein-mediated epigenetic alterations in response to oxidative damage.
N, Ding⋅SA, Miller⋅SS, Savant and HM, O’Hagan
Environmental and molecular mutagenesis. | Journal Article
 
Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer.
SA, Miller⋅SA, Miller⋅RA, Policastro⋅RA, Policastro⋅SS, Savant⋅SS, Savant⋅S, Sriramkumar⋅S, Sriramkumar⋅N, Ding⋅N, Ding⋅X, Lu⋅X, Lu⋅HP, Mohammad⋅HP, Mohammad⋅S, Cao⋅S, Cao⋅JH, Kalin⋅JH, Kalin⋅PA, Cole⋅PA, Cole⋅GE, Zentner⋅GE, Zentner⋅HM, O’Hagan and HM, O’Hagan
Molecular cancer research : MCR. | Journal Article
 
Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells
Pulliam, Nicholas⋅Pulliam, Nicholas⋅Pulliam, Nicholas⋅Tang, Jessica⋅Tang, Jessica⋅Tang, Jessica⋅Wang, Weini⋅Wang, Weini⋅Wang, Weini⋅Fang, Fang⋅Fang, Fang⋅Fang, Fang⋅Sood, Riddhi⋅Sood, Riddhi⋅Sood, Riddhi⋅O'Hagan, Heather M⋅O'Hagan, Heather M⋅⋅Miller, Kathy D⋅Miller, Kathy D⋅Miller, Kathy D⋅Clarke, Robert⋅Clarke, Robert⋅Clarke, Robert⋅Nephew, Kenneth P⋅Nephew, Kenneth P and Nephew, Kenneth P
Cancers. | Journal Article
2018
DVL regulation of tissue-specific aromatase transcripts in breast cancer.
HM, O’Hagan
Oncotarget. | Journal Article
 
Epigenetic Targeting of Adipocytes Inhibits High-Grade Serous Ovarian Cancer Cell Migration and Invasion.
Tang, Jessica⋅J, Tang⋅N, Pulliam⋅Pulliam, Nicholas⋅A, Özeş⋅Özeş, Ali⋅Buechlein, Aaron⋅A, Buechlein⋅Ding, Ning⋅N, Ding⋅H, Keer⋅Keer, Harold⋅Rusch, Doug⋅D, Rusch⋅O'Hagan, Heather⋅H, O’Hagan⋅Stack, M Sharon⋅MS, Stack⋅KP, Nephew and Nephew, Kenneth P
Molecular cancer research : MCR. | Journal Article
 
Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors.
AR, Maiuri⋅H, Li⋅BD, Stein⋅JM, Tennessen and HM, O’Hagan
Cancer & metabolism. | Journal Article
 
The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer
Cancers. | Journal Article
2017
Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.
M, Vaz⋅SY, Hwang⋅I, Kagiampakis⋅J, Phallen⋅A, Patil⋅HM, O’Hagan⋅L, Murphy⋅CA, Zahnow⋅E, Gabrielson⋅VE, Velculescu⋅HP, Easwaran and SB, Baylin
Cancer cell. | Journal Article
 
Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis.
Maiuri, Ashley R⋅AR, Maiuri⋅M, Peng⋅Peng, Michael⋅R, Podicheti⋅S, Sriramkumar⋅CM, Kamplain⋅Sears, Cynthia L⋅DB, Rusch⋅O'Hagan, Heather M⋅CE, DeStefano Shields⋅CL, Sears and HM, O’Hagan
Cancer research. | Journal Article
 
The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases.
N, Ding⋅AR, Maiuri and HM, O’Hagan
Mutation research. | Journal Article
2016
Interplay Between Inflammation and Epigenetic Changes in Cancer.
AR, Maiuri and HM, O’Hagan
Progress in molecular biology and translational science. | Journal Article
 
Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.
CE, DeStefano Shields⋅Destefano Shields, C.E.⋅SW, Van Meerbeke⋅Van Meerbeke, S.W.⋅F, Housseau⋅Housseau, F.⋅H, Wang⋅Wang, H.⋅DL, Huso⋅Huso, D.L.⋅RA, Casero⋅Casero, R.A.⋅O’Hagan, H.M.⋅HM, O’Hagan⋅CL, Sears and Sears, C.L.
The Journal of infectious diseases. | Journal Article