58 Publications (Page 1 of 3)
2023
Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue.
Prabhu, Lakshmi⋅Prabhu, Lakshmi⋅Martin, Matthew⋅Martin, Matthew⋅Chen, Lan⋅Chen, Lan⋅Demir, Özlem⋅Demir, Özlem⋅Jin, Jiamin⋅Jin, Jiamin⋅Huang, Xiumei⋅Huang, Xiumei⋅Motolani, Aishat⋅Motolani, Aishat⋅Sun, Mengyao⋅Sun, Mengyao⋅Jiang, Guanglong⋅Jiang, Guanglong⋅Nakshatri, Harikrishna⋅Nakshatri, Harikrishna⋅Fishel, Melissa L.⋅Fishel, Melissa L⋅Sun, Steven⋅Sun, Steven⋅Safa, Ahmad⋅Safa, Ahmad⋅Amaro, Rommie E⋅Amaro, Rommie E.⋅Kelley, Mark R⋅Kelley, Mark R.⋅Liu, Yunlong⋅Liu, Yunlong⋅Zhang, Zhong-Yin⋅Zhang, Zhong Yin⋅Lu, Tao and Lu, Tao
Genes & diseases, vol. 10, (no. 1), pp. 267-283, January 2023. | Journal Article
2022
A complex signature network that controls the upregulation of PRMT5 in colorectal cancer.
Wei, Han⋅Hartley, Antja-Voy⋅Motolani, Aishat⋅Jiang, Guanglong⋅Safa, Ahmad⋅Prabhu, Lakshmi⋅Liu, Yunlong and Lu, Tao
Genes & diseases, vol. 9, (no. 2), pp. 285-287, March 2022. | Journal Article
2021
The Structure and Functions of PRMT5 in Human Diseases.
Motolani, Aishat⋅Martin, Matthew⋅Sun, Mengyao and Lu, Tao
Life (Basel, Switzerland), vol. 11, (no. 10), October 12, 2021. | Journal Article
2020
Modulating the modulators: regulation of protein arginine methyltransferases by post-translational modifications.
Hartley, Antja-Voy and Lu, Tao
Drug discovery today, vol. 25, (no. 9), pp. 1735-1743, September 2020. | Journal Article
2019
PRMTs and miRNAs: functional cooperation in cancer and beyond.
Jin, Jiamin⋅Martin, Matthew⋅Hartley, Antja-Voy and Lu, Tao
Cell cycle (Georgetown, Tex.), pp. 1-11, June 24, 2019. | Journal Article
2017
Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers.
Prabhu, Lakshmi⋅Prabhu, Lakshmi⋅Wei, Han⋅Wei, Han⋅Chen, Lan⋅Chen, Lan⋅Demir, Özlem⋅Demir, Özlem⋅Sandusky, George⋅Sandusky, George⋅Sun, Emily⋅Sun, Emily⋅Wang, John⋅Wang, John⋅Mo, Jessica⋅Mo, Jessica⋅Zeng, Lifan⋅Zeng, Lifan⋅Fishel, Melissa⋅Fishel, Melissa⋅Safa, Ahmad⋅Safa, Ahmad⋅Amaro, Rommie⋅Amaro, Rommie⋅Korc, Murray⋅Korc, Murray⋅Zhang, Zhong-Yin⋅Zhang, Zhong Yin⋅Lu, Tao and Lu, Tao
Oncotarget, vol. 8, (no. 25), pp. 39963-39977, June 20, 2017. | Journal Article
 
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB
Chen, Mengqian⋅Liang, Jiaxin⋅Ji, Hao⋅Yang, Zhengguan⋅Altilia, Serena⋅Hu, Bing⋅Schronce, Adam⋅McDermott, Martina⋅Schools, Gary⋅Lim, Chang-uk⋅Oliver, David⋅Shtutman, Michael⋅Lu, Tao⋅Stark, George⋅Porter, Donald⋅Broude, Eugenia and Roninson, Igor
Proceedings of the National Academy of Sciences of the United States of America, vol. 114, (no. 38), pp. 10213, 20170919. | Journal Article
 
Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases.
Prabhu, Lakshmi⋅Prabhu, Lakshmi⋅Chen, Lan⋅Chen, Lan⋅Wei, Han⋅Wei, Han⋅Demir, Özlem⋅Demir, Özlem⋅Safa, Ahmad⋅Safa, Ahmad⋅Zeng, Lifan⋅Zeng, Lifan⋅Amaro, Rommie E⋅Amaro, Rommie E⋅O'Neil, Bert H⋅O'Neil, Bert H⋅Zhang, Zhon-Yin⋅Zhang, Zhon-Yin⋅Lu, Tao and Lu, Tao
Molecular bioSystems, November 3, 2017. | Journal Article
 
Novel Serine 176 phosphorylation of YBX1 activates NF-κB in colon cancer.
Martin, Matthew⋅Hua, Laiqing⋅Wang, Benlian⋅Wei, Han⋅Prabhu, Lakshmi⋅Hartley, Antja-Voy⋅Jiang, Guanglong⋅Liu, Yunlong and Lu, Tao
The Journal of biological chemistry, January 11, 2017. | Journal Article
2016
Targeting microenvironment in cancer therapeutics.
Martin, Matthew⋅Wei, Han and Lu, Tao
Oncotarget, June 5, 2016. | Journal Article
2015
Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer.
Prabhu, Lakshmi⋅Mundade, Rasika⋅Wang, Benlian⋅Wei, Han⋅Hartley, Antja-Voy⋅Martin, Matthew⋅McElyea, Kyle⋅Temm, Constance J⋅Sandusky, George⋅Liu, Yunlong and Lu, Tao
Oncotarget, vol. 6, (no. 30), pp. 29396-29412, October 6, 2015. | Journal Article
 
NF-κB: Regulation by Methylation.
Lu, Tao and Stark, George R
Cancer research, vol. 75, (no. 18), pp. 3692-3695, September 15, 2015. | Journal Article
 
Role of Novel Serine 316 Phosphorylation of the p65 Subunit of NF-κB in Differential Gene Regulation.
Wang, Benlian⋅Wei, Han⋅Prabhu, Lakshmi⋅Zhao, Wei⋅Martin, Matthew⋅Hartley, Antja-Voy and Lu, Tao
The Journal of biological chemistry, vol. 290, (no. 33), pp. 20336-20347, August 14, 2015. | Journal Article
 
Role of post-translational modification of the Y box binding protein 1 in human cancers.
Prabhu, Lakshmi⋅Hartley, Antja-Voy⋅Martin, Matthew⋅Warsame, Fadumo⋅Sun, Emily and Lu, Tao
Genes & diseases, vol. 2, (no. 3), pp. 240-246, September 2015. | Journal Article
 
Using sequential immunoprecipitation and mass spectrometry to identify methylation of NF-κB.
Lu, Tao and Stark, George R
Methods in molecular biology (Clifton, N.J.), vol. 1280, pp. 383-393, 2015. | Journal Article
2014
Critical role of NF-κB in pancreatic cancer.
Prabhu, Lakshmi⋅Mundade, Rasika⋅Korc, Murray⋅Loehrer, Patrick J and Lu, Tao
Oncotarget, vol. 5, (no. 22), pp. 10969-10975, November 30, 2014. | Journal Article
 
DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway.
Pang, Yingxin⋅Si, Manfei⋅Sun, Bin⋅Niu, Leilei⋅Xu, Xia⋅Lu, Tao⋅Yuan, Huiqing and Lou, Hongxiang
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, vol. 69, pp. 163-174, July 2014. | Journal Article
 
Genetic pathways, prevention, and treatment of sporadic colorectal cancer.
Mundade, Rasika⋅Imperiale, Thomas F⋅Prabhu, Lakshmi⋅Loehrer, Patrick J and Lu, Tao
Oncoscience, vol. 1, (no. 6), pp. 400-406, 2014. | Journal Article
 
Protein arginine methylation of non-histone proteins and its role in diseases.
Wei, Han⋅Mundade, Rasika⋅Lange, Kevin C and Lu, Tao
Cell cycle (Georgetown, Tex.), vol. 13, (no. 1), pp. 32-41, 2014/Jan/1. | Journal Article
 
Role of ChIP-seq in the discovery of transcription factor binding sites, differential gene regulation mechanism, epigenetic marks and beyond.
Mundade, Rasika⋅Ozer, Hatice Gulcin⋅Wei, Han⋅Prabhu, Lakshmi and Lu, Tao
Cell cycle (Georgetown, Tex.), vol. 13, (no. 18), pp. 2847-2852, 2014. | Journal Article
2013
PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.
Zhang, Tiejun⋅Park, Kyeong Ah⋅Li, Yuwen⋅Byun, Hee Sun⋅Jeon, Juhee⋅Lee, Yoonjung⋅Hong, Jang Hee⋅Kim, Jin Man⋅Huang, Song-Mei⋅Choi, Seung-Won⋅Kim, Seon-Hwan⋅Sohn, Kyung-Cheol⋅Ro, Hyunju⋅Lee, Ji Hoon⋅Lu, Tao⋅Stark, George R⋅Shen, Han-Ming⋅Liu, Zheng-Gang⋅Park, Jongsun and Hur, Gang Min
Nature communications, vol. 4, pp. 2062, 2013. | Journal Article
 
PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB.
Wei, Han⋅Wang, Benlian⋅Miyagi, Masaru⋅She, Yun⋅Gopalan, Banu⋅Huang, De-Bin⋅Ghosh, Gourisankar⋅Stark, George R and Lu, Tao
Proceedings of the National Academy of Sciences of the United States of America, vol. 110, (no. 33), pp. 13516-21, 2013/Aug/13. | Journal Article
 
Role of lysine methylation of NF-?B in differential gene regulation
Lu, Tao⋅Yang, Maojing⋅Huang, De-Bin⋅Wei, Han⋅Ozer, Gulcin H⋅Ghosh, Gourisankar and Stark, George R
Proceedings of the National Academy of Sciences of the United States of America, vol. 110, (no. 33), Aug 13, 2013. | Journal Article
 
Role of lysine methylation of NF-κB in differential gene regulation.
Lu, Tao⋅Yang, Maojing⋅Huang, De-Bin⋅Wei, Han⋅Ozer, Gulcin H⋅Ghosh, Gourisankar and Stark, George R
Proceedings of the National Academy of Sciences of the United States of America, vol. 110, (no. 33), pp. 13510-5, 2013/Aug/13. | Journal Article
2012
Cytokine-induced human islet cell death in vitro correlates with a persistently high phosphorylation of STAT-1, but not with NF-κB activation.
Hindlycke, Henrietta⋅Lu, Tao and Welsh, Nils
Biochemical and biophysical research communications, vol. 418, (no. 4), pp. 845-850, February 24, 2012. | Journal Article