7 Publications
2023
Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer ′s disease
 
TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo. Cells
Lee-Gosselin, Audrey⋅Jury-Garfe, Nur⋅You, Yanwen⋅Dabin, Luke⋅Soni, Disha⋅Dutta, Sayan⋅Rochet, Jean-Christophe⋅Kim, Jungsu⋅Oblak, Adrian L. and Lasagna-Reeves, Cristian A.
. | Journal Article
2022
The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease
Moutinho, Miguel⋅Moutinho, Miguel⋅Puntambekar, Shweta S.⋅Puntambekar, Shweta S.⋅Tsai, Andy P.⋅Tsai, Andy P.⋅Coronel, Israel⋅Coronel, Israel⋅Lin, Peter B.⋅Lin, Peter B.⋅Casali, Brad T.⋅Casali, Brad T.⋅Martinez, Pablo⋅Martinez, Pablo⋅Oblak, Adrian L.⋅Oblak, Adrian L.⋅Lasagna-Reeves, Cristian A.⋅Lasagna-Reeves, Cristian A.⋅Lamb, Bruce T.⋅Lamb, Bruce T.⋅Landreth, Gary E. and Landreth, Gary E.
Science Translational Medicine, vol. 14. | Journal Article
 
The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity. Brain Communications
2021
PATHOLOGICAL TAU AND REACTIVE ASTROGLIOSIS ARE ASSOCIATED WITH DISTINCT FUNCTIONAL DEFICITS IN A MOUSE MODEL OF TAUOPATHY.
Neurobiology of Aging. | Journal Article
2020
A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy
Taylor, Xavier⋅Cisternas, Pablo⋅You, Yanwen⋅You, Yingjian⋅Xiang, Shunian⋅Marambio, Yamil⋅Zhang, Jie⋅Vidal, Ruben and Lasagna-Reeves, Cristian A.
Journal of Neuroinflammation, vol. 17. | Journal Article
2019
P4‐131: TAU AS A MEDIATOR OF NEUROTOXICITY ASSOCIATED TO CEREBRAL AMYLOID ANGIOPATHY
You, Yingjian⋅You, Yingjian⋅Perkins, Abigail⋅Perkins, Abigail⋅Cisternas, Pablo⋅Cisternas, Pablo⋅Munoz, Braulio⋅Munoz, Braulio⋅Taylor, Xavier⋅Taylor, Xavier⋅You, Yanwen⋅You, Yanwen⋅Oblak, Adrian L⋅Oblak, Adrian L⋅Atwood, Brady⋅Atwood, Brady⋅Vidal, Ruben⋅Vidal, Ruben⋅Lasagna Reeves, Cristian A and Lasagna Reeves, Cristian A
Alzheimer's & Dementia, vol. 15, pp. P1326, July 2019. | Journal Article