My lab is interested in understanding mechanisms responsible for changes in synaptic connectivity in the nervous system. We study synaptic rearrangements at a model synapse, the neuromuscular junction between motoneurons and muscle fibers, due to its large size, experimental accessibility, and ease of manipulation.
A second area of focus involves understanding cellular mechanisms of synapse and motoneuron loss in a mouse model of amyotrophic lateral sclerosis (ALS or Lou Gherig's Disease).
Expertise: Spinal Cord and Brain Injury Research
