Expertise

Current Research Interests: Mdm2 was initially described as an oncogene through its ability to transform cells. Clinically, Mdm2 is not detected in normal tissue but is detectable in 40-80% of various types of late stage cancers (adult and children). It remains unclear whether there are specific transcription factors that are necessary to elevate mdm2 gene expression in response to growth factors and cytokines, which are highly elevated in the tumor microenvironment. In addition, there are major voids in our understanding of how Mdm2 is regulated at the post-translational level to regulate proteins in tumor cells to promote metastasis in response to the growth factors and cytokines in the tumor microenvironment

His research focus was in Biochemistry and Molecular Biology focused on the regulation of Mdm2 oncogene.

Past Affiliations

Member, IU Melvin and Bren Simon Cancer Center, Centers and Institutes, Indiana University School of Medicine

Member, Herman B. Wells Center for Pediatric Research, Centers and Institutes, Indiana University School of Medicine

Assistant Professor, BSTP: Graduate Programs in Biomedical Sciences, School of Medicine, Case Western Reserve University (past)

Associate Professor, Department of Biochemistry and Molecular Biology

Assistant Professor, Case Comprehensive Cancer Center

Associate Professor, Pediatric Hematology/Oncology

Assistant Professor, Department of Biochemistry and Molecular Biology

Communities
Biochemistry, Molecular Biology, Pediatrics, Pediatrics, Cellular Biochemistry, Molecular Biochemistry
Degrees
PhD, Wright State University, Biomedical Sciences, 1997
BS, Indiana State University, Life Sciences, 1992