238 Publications (Page 1 of 10)
2020
Early Data on Long-Term Efficacy and Safety of Inotersen in Patients With Hereditary Transthyretin Amyloidosis: A 2-Year Update From the Open-Label Extension of the NEURO-TTR Trial
Brannagan, 3rd, Thomas H⋅Wang, Annabel K⋅Coelho, Teresa⋅Waddington Cruz, Marcia⋅Polydefkis, Michael J⋅Dyck, Peter J⋅Plante-Bordeneuve, Violaine⋅Berk, John L⋅Barroso, Fabio⋅Merlini, Giampaolo⋅Conceição, Isabel⋅Hughes, Steven G⋅Kwoh, Jesse⋅Jung, Shiangtung W⋅Guthrie, Spencer⋅Pollock, Michael⋅Benson, Merrill D and Gertz, Morie
European journal of neurology, 2020-Apr-28. | Journal Article
 
Editorial Commentary: Advances in transthyretin amyloid cardiomyopathy
Benson, Merrill D⋅Benson, Merrill D⋅Dasgupta, Noel R and Dasgupta, Noel R
Trends in Cardiovascular Medicine, 2020-Jan-07. | Journal Article
 
Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis
Coelho, Teresa⋅Coelho, Teresa⋅⋅⋅Waddington-Cruz, Marcia⋅Waddington-Cruz, Marcia⋅White, Michelle K⋅White, Michelle K⋅Lovley, Andrew⋅Lovley, Andrew⋅Pollock, Michael⋅Pollock, Michael⋅Guthrie, Spencer⋅Guthrie, Spencer⋅Ackermann, Elizabeth J⋅Ackermann, Elizabeth J⋅Hughes, Steven G⋅Hughes, Steven G⋅Obici, Laura⋅Obici, Laura⋅Schmidt, Hartmut H⋅Schmidt, Hartmut H⋅Polydefkis, Michael⋅Polydefkis, Michael⋅Benson, Merrill D⋅Benson, Merrill D⋅Berk, John L and Berk, John L
Journal of Neurology, vol. 267, (no. 4), pp. 1070-1079, Apr 2020. | Journal Article
 
Inotersen therapy of transthyretin amyloid cardiomyopathy
Dasgupta, Noel R⋅Dasgupta, Noel R⋅Dasgupta, Noel R⋅Rissing, Stacy M⋅Rissing, Stacy M⋅Rissing, Stacy M⋅Smith, Jessica⋅Smith, Jessica⋅Smith, Jessica⋅Jung, Jeesun⋅Jung, Jeesun⋅Jung, Jeesun⋅Benson, Merrill D⋅Benson, Merrill D and Benson, Merrill D
Amyloid, vol. 27, (no. 1), pp. 58, 1/2/2020. | Journal Article
2019
A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH
Ueda, Mitsuharu⋅Okada, Masamitsu⋅Mizuguchi, Mineyuki⋅Kluve-Beckerman, Barbara⋅Kanenawa, Kyosuke⋅Isoguchi, Aito⋅Misumi, Yohei⋅Tasaki, Masayoshi⋅Ueda, Akihiko⋅Kanai, Akinori⋅Sasaki, Ryoko⋅Masuda, Teruaki⋅Inoue, Yasuteru⋅Nomura, Toshiya⋅Shinriki, Satoru⋅Shuto, Tsuyoshi⋅Kai, Hirofumi⋅Yamashita, Taro⋅Matsui, Hirotaka⋅Benson, Merrill D and Ando, Yukio
The Journal of biological chemistry, vol. 294, (no. 29), pp. 11275, 2019-07-19. | Journal Article
 
ALECT2 and NASH
Cummings, Oscar W⋅Cummings, Oscar W⋅Dasgupta, Noel R⋅Dasgupta, Noel R⋅Benson, Merrill D and Benson, Merrill D
Amyloid: Proceedings of the XVI International Symposium on Amyloidosis Kumamoto, Japan 26-29 March 2018, vol. 26, (no. sup1), pp. 159, 3/29/2019. | Journal Article
 
Amyloidosis: diagnosis and new therapies for a misunderstood and misdiagnosed disease
Thomas, Victoria E⋅Thomas, Victoria E⋅Smith, Justin⋅Smith, Justin⋅Benson, Merrill D⋅Benson, Merrill D⋅Dasgupta, Noel R and Dasgupta, Noel R
Neurodegenerative disease management, vol. 9, (no. 6), pp. 289, 2019-12-00. | Journal Article
 
A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils
Saelices, Lorena⋅Nguyen, Binh⋅Chung, Kevin⋅Wang, Yifei⋅Ortega, Alfredo⋅Lee, Ji⋅Coelho, Teresa⋅Bijzet, Johan⋅Benson, Merrill and Eisenberg, David
Journal of Biological Chemistry, vol. 294, (no. 15), pp. 6141, 2019-04-12. | Journal Article
 
A transgenic mouse model reproduces human hereditary systemic amyloidosis
Chabert, Michèle⋅Chabert, Michèle⋅Rousset, Xavier⋅Rousset, Xavier⋅Colombat, Magali⋅Colombat, Magali⋅Lacasa, Michel⋅Lacasa, Michel⋅Kakanakou, Hermine⋅Kakanakou, Hermine⋅Bourderioux, Mathilde⋅Bourderioux, Mathilde⋅Brousset, Pierre⋅Brousset, Pierre⋅Burlet-Schiltz, Odile⋅Burlet-Schiltz, Odile⋅Liepnieks, Juris J⋅Liepnieks, Juris J⋅Kluve-Beckerman, Barbara⋅Kluve-Beckerman, Barbara⋅Lambert, Gilles⋅Lambert, Gilles⋅Châtelet, François P⋅Châtelet, François P⋅Benson, Merrill D⋅Benson, Merrill D⋅Kalopissis, Athina D and Kalopissis, Athina D
Kidney International, vol. 96, (no. 3), pp. 641, September 2019. | Journal Article
 
IMPROVED SURVIVAL OF PATIENTS WITH TRANSTHYRETIN AMYLOID CARDIOMYOPATHY WITH INOTERSEN (TTR SPECIFIC ANTISENSE OLIGONUCLEOTIDE)
Dasgupta, Noel Rakhi⋅Dasgupta, Noel Rakhi⋅Benson, Merrill and Benson, Merrill
Journal of the American College of Cardiology, vol. 73, (no. 9), pp. 811, 2019-03-12. | Journal Article
 
Inotersen (transthyretin-specific antisense oligonucleotide) for treatment of transthyretin amyloidosis
Benson, Merrill D⋅Benson, Merrill D⋅Dasgupta, Noel R⋅Dasgupta, Noel R⋅Monia, Brett P and Monia, Brett P
Neurodegenerative Disease Management, vol. 9, (no. 1), pp. 30, 2019-02-00. | Journal Article
 
Inotersen treatment for ATTR amyloidosis
Benson, Merrill D
Amyloid: Proceedings of the XVI International Symposium on Amyloidosis Kumamoto, Japan 26-29 March 2018, vol. 26, (no. sup1), pp. 28, 3/29/2019. | Journal Article
 
'Misfolded' proteins are common cause of heart failure
Dasgupta, Noel and Benson, Merrill
Indianapolis Business Journal, vol. 39, (no. 49), pp. 19, 20190201. | Journal Article
 
Rationale and Design of a Phase 3 Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)
Falk, Rodney H⋅Gertz, Morie A⋅Benson, Merrill D⋅Buchele, Gustavo⋅Brambatti, Michela⋅Tsimikas, Sotirios⋅Viney, Nicholas J⋅Tai, Li-Jung⋅Monteiro, Cecilia⋅Yang, Qingqing⋅O'Dea, Louis St L⋅Karwatowska-Prokopczuk, Ewa⋅Schneider, Eugene⋅Geary, Richard S and Monia, Brett P
Blood, vol. 134, (no. Supplement_1), pp. 5764, 2019-11-13. | Journal Article
 
SAFETY OF INOTERSEN TREATMENT IN PATIENTS WITH TRANSTHYRETIN AMYLOID CARDIOMYOPATHY
Dasgupta, Noel R⋅Dasgupta, Noel R⋅Falk, Rodney H⋅Falk, Rodney H⋅Drachman, Brian M⋅Drachman, Brian M⋅Maurer, Mathew S⋅Maurer, Mathew S⋅Whelan, Carol J⋅Whelan, Carol J⋅Brannagan, Thomas⋅Brannagan, Thomas⋅Coelho, Teresa⋅Coelho, Teresa⋅Cruz, Marcia Waddington⋅Cruz, Marcia Waddington⋅Damy, Thibaud⋅Damy, Thibaud⋅Hanna, Mazen⋅Hanna, Mazen⋅Berk, John L⋅Berk, John L⋅Merlini, Giampaolo⋅Merlini, Giampaolo⋅Conceição, Isabel⋅Conceição, Isabel⋅Hughes, Steven G⋅Hughes, Steven G⋅Kwoh, Jesse⋅Kwoh, Jesse⋅Jung, Shiangtung W⋅Jung, Shiangtung W⋅Guthrie, Spencer⋅Guthrie, Spencer⋅Pollock, Michael⋅Pollock, Michael⋅Gertz, Morie⋅Gertz, Morie⋅Benson, Merrill D⋅Benson, Merrill D⋅Heitner, Stephen and Heitner, Stephen
Journal of the American College of Cardiology, vol. 73, (no. 9), pp. 909, 2019-03-12. | Journal Article
 
Treatment of ATTR cardiomyopathy with a TTR specific antisense oligonucleotide, inotersen
Dasgupta, Noel R⋅Dasgupta, Noel R⋅Benson, Merrill D and Benson, Merrill D
Amyloid: Proceedings of the XVI International Symposium on Amyloidosis Kumamoto, Japan 26-29 March 2018, vol. 26, (no. sup1), pp. 21, 3/29/2019. | Journal Article
2018
Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee
Benson, Merrill D⋅Buxbaum, Joel N⋅Eisenberg, David S⋅Merlini, Giampaolo⋅Saraiva, Maria J. M⋅Sekijima, Yoshiki⋅Sipe, Jean D and Westermark, Per
Amyloid, vol. 25, (no. 4), pp. 219, 10/2/2018. | Journal Article
 
Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition
Zhang, Huina⋅Kirkman, Laura⋅Swanson, Larry⋅Saelices, Lorena⋅Swanson, Larry⋅Nuebler, Johannes⋅Chung, Kevin⋅Liu, Jian⋅Hahn, Joel⋅Fudenberg, Geoffrey⋅Hahn, Joel⋅Zhan, Wenhu⋅Jeub, Lucas⋅Jeub, Lucas⋅Lee, Ji⋅Imakaev, Maxim⋅Qu, Dan⋅Visone, Joseph⋅Abdennur, Nezar⋅Wang, Li⋅Dziedziech, Alexis⋅Fortunato, Santo⋅Fortunato, Santo⋅Cohn, Whitaker⋅Singh, Pradeep⋅Sporns, Olaf⋅Sporns, Olaf⋅Whitelegge, Julian⋅Mirny, Leonid A⋅Wong, Chi⋅Lau, Chi-Wai⋅Fan, Hao⋅Benson, Merrill⋅Huang, Yuhong⋅Eisenberg, David⋅Tong, Xinran⋅Bruzual, Igor⋅Wang, Yi⋅Hara, Ryoma⋅Huang, Huihui⋅Kawasaki, Masanori⋅Xia, Yin⋅Xiang, Li⋅Imaeda, Toshihiro⋅Okamoto, Rei⋅Cai, Zongwei⋅Liu, Pingsheng⋅Sato, Kenjiro⋅Michino, Mayako⋅Wei, Yongxiang⋅Yao, Xiaoqiang⋅Alvaro, Elena⋅Ma, Ronald⋅Guiang, Liselle⋅Huang, Yu⋅Sanz, Laura⋅Mota, Daniel⋅Govindasamy, Kavitha⋅Wang, Rong⋅Ling, Yan⋅Tumwebaze, Patrick⋅Sukenick, George⋅Shi, Lei⋅Vendome, Jeremie⋅Bhanot, Purnima⋅Rosenthal, Philip⋅Aso, Kazuyoshi⋅Foley, Michael⋅Cooper, Roland⋅Kafsack, Bjorn⋅Doggett, J.⋅Nathan, Carl and Lin, Gang
Proceedings of the National Academy of Sciences of the United States, vol. 115, (no. 29), pp. 7463, 20180717. | Journal Article
 
Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition.
Saelices, Lorena⋅Chung, Kevin⋅Lee, Ji H⋅Cohn, Whitaker⋅Whitelegge, Julian P⋅Benson, Merrill D and Eisenberg, David S
Proceedings of the National Academy of Sciences of the United States of America, June 28, 2018. | Journal Article
 
Hereditary transthyretin amyloidosis: baseline characteristics of patients in the NEURO-TTR trial
Waddington-Cruz, Marcia⋅Waddington-Cruz, Marcia⋅Ackermann, Elizabeth J⋅Ackermann, Elizabeth J⋅Polydefkis, Michael⋅Polydefkis, Michael⋅Heitner, Stephen B⋅Heitner, Stephen B⋅Dyck, Peter J⋅Dyck, Peter J⋅Barroso, Fabio A⋅Barroso, Fabio A⋅Wang, Annabel K⋅Wang, Annabel K⋅Berk, John L⋅Berk, John L⋅Dyck, P James B⋅Dyck, P. James B⋅Monia, Brett P⋅Monia, Brett P⋅Hughes, Steven G⋅Hughes, Steven G⋅Tai, Li⋅Tai, Li⋅Jesse Kwoh, T⋅Jesse Kwoh, T⋅Jung, Shiangtung W⋅Jung, Shiangtung W⋅Coelho, Teresa⋅Coelho, Teresa⋅Benson, Merrill D⋅Benson, Merrill D⋅Gertz, Morie A and Gertz, Morie A
Amyloid, vol. 25, (no. 3), pp. 188, 7/3/2018. | Journal Article
 
INOTERSEN IMPROVES QUALITY OF LIFE IN PATIENTS WITH HEREDITARY TRANSTHYRETIN AMYLOIDOSIS WITH POLYNEUROPATHY AND CARDIOMYOPATHY: RESULTS OF THE PHASE 3 STUDY NEURO-TTR
Maurer, Mathew S⋅Heitner, Stephen⋅Drachman, Brian⋅Whelan, Carol⋅Guthrie, Spencer⋅Tai, Li⋅Hughes, Steve G⋅Monia, Brett P⋅Ackermann, Elizabeth J and Benson, Merrill D
Journal of the American College of Cardiology, vol. 71, (no. 11), pp. A658, 2018-03-10. | Journal Article
 
Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis
Benson, Merrill D⋅Benson, Merrill D⋅Benson, Merrill D⋅Waddington-Cruz, Márcia⋅Waddington-Cruz, Márcia⋅Waddington-Cruz, Márcia⋅Berk, John L⋅Berk, John L⋅Berk, John L⋅Polydefkis, Michael⋅Polydefkis, Michael⋅Polydefkis, Michael⋅Dyck, Peter J⋅Dyck, Peter J⋅Dyck, Peter J⋅Wang, Annabel K⋅Wang, Annabel K⋅Wang, Annabel K⋅Planté-Bordeneuve, Violaine⋅Planté-Bordeneuve, Violaine⋅Planté-Bordeneuve, Violaine⋅Barroso, Fabio A⋅Barroso, Fabio A⋅Barroso, Fabio A⋅Merlini, Giampaolo⋅Merlini, Giampaolo⋅Merlini, Giampaolo⋅Obici, Laura⋅Obici, Laura⋅Obici, Laura⋅Scheinberg, Morton⋅Scheinberg, Morton⋅Scheinberg, Morton⋅Brannagan, Thomas H⋅Brannagan, Thomas H⋅Brannagan, Thomas H⋅Litchy, William J⋅Litchy, William J⋅Litchy, William J⋅Whelan, Carol⋅Whelan, Carol⋅Whelan, Carol⋅Drachman, Brian M⋅Drachman, Brian M⋅Drachman, Brian M⋅Adams, David⋅Adams, David⋅Adams, David⋅Heitner, Stephen B⋅Heitner, Stephen B⋅Heitner, Stephen B⋅Conceição, Isabel⋅Conceição, Isabel⋅Conceição, Isabel⋅Schmidt, Hartmut H⋅Schmidt, Hartmut H⋅Schmidt, Hartmut H⋅Vita, Giuseppe⋅Vita, Giuseppe⋅Vita, Giuseppe⋅Campistol, Josep M⋅Campistol, Josep M⋅Campistol, Josep M⋅Gamez, Josep⋅Gamez, Josep⋅Gamez, Josep⋅Gorevic, Peter D⋅Gorevic, Peter D⋅Gorevic, Peter D⋅Gane, Edward⋅Gane, Edward⋅Gane, Edward⋅Shah, Amil M⋅Shah, Amil M⋅Shah, Amil M⋅Solomon, Scott D⋅Solomon, Scott D⋅Solomon, Scott D⋅Monia, Brett P⋅Monia, Brett P⋅Monia, Brett P⋅Hughes, Steven G⋅Hughes, Steven G⋅Hughes, Steven G⋅Kwoh, T Jesse⋅Kwoh, T Jesse⋅Kwoh, T. Jesse⋅McEvoy, Bradley W⋅McEvoy, Bradley W⋅McEvoy, Bradley W⋅Jung, Shiangtung W⋅Jung, Shiangtung W⋅Jung, Shiangtung W⋅Baker, Brenda F⋅Baker, Brenda F⋅Baker, Brenda F⋅Ackermann, Elizabeth J⋅Ackermann, Elizabeth J⋅Ackermann, Elizabeth J⋅Gertz, Morie A⋅Gertz, Morie A⋅Gertz, Morie A⋅Coelho, Teresa⋅Coelho, Teresa and Coelho, Teresa
The New England Journal of Medicine, vol. 379, (no. 1), pp. 31, 20180705. | Journal Article
 
Long-term Treatment with Inotersen for Amyloid Transthyretin Amyloidosis Cardiomyopathy
Dasgupta, Noel⋅Dasgupta, Noel⋅Benson, Merrill and Benson, Merrill
Journal of Cardiac Failure, vol. 24, (no. 8), pp. S59, August 2018. | Journal Article
 
Long-Term Update from the Open-Label Extension of the NEURO-TTR Study in Patients with Hereditary Transthyretin Amyloidosis
Brannagan, Thomas⋅Wang, Annabel K⋅Coelho, Teresa⋅Waddington Cruz, Marcia⋅Polydefkis, Michael J⋅Dyck, Peter J⋅Plante-Bordeneuve, Violaine⋅Berk, John L⋅Barroso, Fabio⋅Merlini, Giampaolo⋅Conceição, Isabel⋅Hughes, Steven G⋅Kwoh, Jesse G⋅Jung, Shiangtung W⋅Guthrie, Spencer⋅Pollock, Michael⋅Benson, Merrill D and Gertz, Morie A
Blood, vol. 132, (no. Supplement 1), pp. 498, 2018-11-29. | Journal Article
 
POTENTIAL REVERSAL OF TRANSTHYRETIN AMYLOID CARDIOMYOPATHY WITH TTR SPECIFIC ANTISENSE OLIGONUCLEOTIDE THERAPY
Dasgupta, Noel Rakhi⋅Dasgupta, Noel Rakhi⋅Benson, Merrill D and Benson, Merrill D
Journal of the American College of Cardiology, vol. 71, (no. 11), pp. A660, 2018-03-10. | Journal Article