63 Publications (Page 1 of 3)
2019
266-LB: Evidence for a Hexosamine Biosynthesis Pathway-Mediated Sp1 Cholesterolgenic Response Being an Early Etiological Factor of Insulin Resistance
GRICE, BRIAN A⋅COVERT, JACOB D⋅KREILACH, ALEC M⋅THORNBURG, MATTHEW⋅TACKETT, LIXUAN⋅MCCLAIN, DON and Elmendorf, Jeffrey S
Diabetes, vol. 68, (no. Supplement 1), pp. 266, 2019-06-00. | Journal Article
 
Excess membrane cholesterol is an early contributing reversible aspect of skeletal muscle insulin resistance in C57BL/6NJ mice fed a Western-style high-fat diet
Grice, Brian A⋅Barton, Kelly J⋅Covert, Jacob D⋅Kreilach, Alec M⋅Tackett, Lixuan⋅Brozinick, Joseph T and Elmendorf, Jeffrey S
American journal of physiology. Endocrinology and metabolism, vol. 317, (no. 2), pp. E373, 2019-08-01. | Journal Article
2018
Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants
Li, Wei⋅Li, Wei⋅Li, Wei⋅Li, Wei⋅Li, Wei⋅Li, W.⋅Risacher, Shannon L⋅Risacher, Shannon L⋅Risacher, S.L.⋅Risacher, Shannon L⋅Risacher, Shannon L⋅Risacher, Shannon L⋅Gao, S.⋅Gao, Sujuan⋅Gao, Sujuan⋅Gao, Sujuan⋅Gao, Sujuan⋅Gao, Sujuan⋅Boehm, Stephen L⋅Boehm, Stephen L⋅Boehm, Stephen L⋅Boehm, S.L.⋅Boehm, Stephen L⋅Boehm, Stephen L⋅Elmendorf, Jeffrey S⋅Elmendorf, Jeffrey S⋅Elmendorf, Jeffrey S⋅Elmendorf, Jeffrey S⋅Elmendorf, Jeffrey S⋅Elmendorf, J.S.⋅Saykin, Andrew J⋅Saykin, Andrew J⋅Saykin, A.J.⋅Saykin, Andrew J⋅Saykin, Andrew J and Saykin, Andrew J
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 10, (no. 1), pp. 98, 2018. | Journal Article
2017
Exercise training prevents skeletal muscle plasma membrane cholesterol accumulation, cortical actin filament loss, and insulin resistance in C57BL/6J mice fed a western‐style high‐fat diet
Ambery, Ashley G⋅Tackett, Lixuan⋅Penque, Brent A⋅Brozinick, Joseph T and Elmendorf, Jeffrey S
Physiological Reports, vol. 5, (no. 16), pp. n/a, August 2017. | Journal Article
 
New Aspects of Cellular Cholesterol Regulation on Blood Glucose Control—Review and Perspective on the Impact of Statin Medications on Metabolic Health
Grice, Brian A and Elmendorf, Jeffrey S
US Endocrinology, vol. 13, (no. 2), pp. 63, 2017-00-00. | Journal Article
 
The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)–mediated glucose uptake into skeletal muscle cells
Tunduguru, Ragadeepthi⋅Zhang, Jing⋅Aslamy, Arianne⋅Salunkhe, Vishal A⋅Brozinick, Joseph T⋅Elmendorf, Jeffrey S and Thurmond, Debbie C
The Journal of biological chemistry, vol. 292, (no. 46), pp. 19043, 2017-Nov-17. | Journal Article
2015
Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach.
Han, X⋅Quinney, S K⋅Wang, Z⋅Zhang, P⋅Duke, J⋅Desta, Z⋅Elmendorf, J S⋅Flockhart, D A and Li, L
Clinical pharmacology and therapeutics, vol. 98, (no. 3), pp. 321-327, September 2015. | Journal Article
2014
Chromium enhances insulin responsiveness via AMPK.
Hoffman, N.J.⋅Hoffman, Nolan J⋅Hoffman, N.J.⋅Penque, B.A.⋅Penque, Brent A⋅Penque, B.A.⋅Habegger, K.M.⋅Habegger, Kirk M⋅Habegger, K.M.⋅Sealls, W.⋅Sealls, W.⋅Sealls, Whitney⋅Tackett, Lixuan⋅Tackett, L.⋅Tackett, L.⋅Elmendorf, Jeffrey S⋅Elmendorf, J.S. and Elmendorf, J.S.
The Journal of nutritional biochemistry, vol. 25, (no. 5), pp. 565-72, 2014/May. | Journal Article
 
Effect of Corncob bedding on feed conversion efficiency in a high-fat diet-induced prediabetic model in C57Bl/6J mice
Ambery, Ashley G⋅Ambery, Ashley⋅Tackett, Lixuan⋅Tackett, Lixuan⋅Penque, Brent A⋅Penque, Brent⋅Hickman, Debra L⋅Hickman, Debra⋅Elmendorf, Jeffrey and Elmendorf, Jeffrey S
Journal of the American Association for Laboratory Animal Science : JAALAS, vol. 53, (no. 5), pp. 451, 2014-Sep. | Journal Article
 
Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.
Tunduguru, Ragadeepthi⋅Chiu, Tim T⋅Ramalingam, Latha⋅Elmendorf, Jeffrey S⋅Klip, Amira and Thurmond, Debbie C
Biochemical pharmacology, vol. 92, (no. 2), pp. 380-388, November 15, 2014. | Journal Article
2013
Hexosamine biosynthesis impairs insulin action via a cholesterolgenic response.
Penque, Brent A⋅Hoggatt, April M⋅Herring, B. P and Elmendorf, Jeffrey S
Molecular endocrinology (Baltimore, Md.), vol. 27, (no. 3), pp. 536-47, 2013/Mar. | Journal Article
 
Trivalent Chromium Modulates Hexosamine Biosynthesis Pathway Transcriptional Activation of Cholesterol Synthesis and Insulin Resistance
Penque, Brent A⋅Tackett, Lixuan and Elmendorf, Jeffrey S
Open Journal of Endocrine and Metabolic Diseases, vol. 3, (no. 4), pp. 8, 2013-00-00. | Journal Article
2012
AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol.
Habegger, Kirk M⋅Habegger, K.M.⋅Habegger, K.M.⋅Hoffman, N.J.⋅Hoffman, Nolan J⋅Hoffman, N.J.⋅Ridenour, C.M.⋅Ridenour, C.M.⋅Ridenour, Colin M⋅Brozinick, Joseph⋅Brozinick, J.T.⋅Brozinick, J.T.⋅Elmendorf, Jeffrey S⋅Elmendorf, J.S. and Elmendorf, J.S.
Endocrinology, vol. 153, (no. 5), pp. 2130-41, 2012/May. | Journal Article
 
Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle.
Habegger, K M⋅Habegger, K.M.⋅Habegger, K.M.⋅Penque, B.A.⋅Penque, B A⋅Penque, B.A.⋅Sealls, W⋅Sealls, W.⋅Sealls, W.⋅Tackett, L.⋅Tackett, L⋅Tackett, L.⋅Bell, L.N.⋅Bell, Lauren N⋅Bell, L.N.⋅Blue, E K⋅Blue, E.K.⋅Blue, E.K.⋅Gallagher, P.J.⋅Gallagher, P.J.⋅Gallagher, P J⋅Sturek, M.⋅Sturek, M⋅Sturek, M.⋅Alloosh, M A⋅Alloosh, M.A.⋅Alloosh, M.A.⋅Steinberg, H.O.⋅Steinberg, H O⋅Steinberg, H.O.⋅Considine, R.V.⋅Considine, R.V.⋅Considine, Robert V⋅Elmendorf, J S⋅Elmendorf, J.S. and Elmendorf, J.S.
Diabetologia, vol. 55, (no. 2), pp. 457-67, 2012/Feb. | Journal Article
 
Fretting about fat: a new look at the lipid droplet surface and the roundabout role of Plin2 in cellular lipid storage: focus on "Direct interaction of Plin2 with lipids on the surface of lipid droplets: a live cell FRET analysis".
Elmendorf, Jeffrey S
American journal of physiology. Cell physiology, vol. 303, (no. 7), pp. C713-4, 2012/Oct/1. | Journal Article
2011
Evidence coupling increased hexosamine biosynthesis pathway activity to membrane cholesterol toxicity and cortical filamentous actin derangement contributing to cellular insulin resistance.
Bhonagiri, P.⋅Bhonagiri, Padma⋅Bhonagiri, P.⋅Pattar, G.R.⋅Pattar, Guruprasad R⋅Pattar, G.R.⋅Habegger, K.M.⋅Habegger, Kirk M⋅Habegger, K.M.⋅McCarthy, A.M.⋅McCarthy, A.M.⋅McCarthy, Alicia M⋅Tackett, Lixuan⋅Tackett, L.⋅Tackett, L.⋅Elmendorf, Jeffrey S⋅Elmendorf, J.S. and Elmendorf, J.S.
Endocrinology, vol. 152, (no. 9), pp. 3373-84, 2011/Sep. | Journal Article
 
Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia--brief report.
Sealls, Whitney⋅Penque, Brent A and Elmendorf, Jeffrey S
Arteriosclerosis, thrombosis, and vascular biology, vol. 31, (no. 5), pp. 1139-40, 2011/May. | Journal Article
 
Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis
Jewell, Jenna L⋅Jewell, J. L.⋅Oh, Eunjin⋅Oh, E.⋅Ramalingam, Latha⋅Ramalingam, L.⋅Kalwat, Michael A⋅Kalwat, M. A.⋅Tagliabracci, Vincent S⋅Tagliabracci, V. S.⋅Tackett, L.⋅Tackett, Lixuan⋅Elmendorf, Jeffrey S⋅Elmendorf, J. S.⋅Thurmond, D. C. and Thurmond, Debbie
The Journal of Cell Biology, vol. 193, (no. 1), Apr 4, 2011. | Journal Article
 
Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis.
Hoffman, Nolan J and Elmendorf, Jeffrey S
Trends in endocrinology and metabolism: TEM, vol. 22, (no. 3), pp. 110-6, 2011/Mar. | Journal Article
2010
Monitoring Submicron and Micron-Size Membrane Compartments using Quantum Dots Monovalently Conjugated to Tracer Molecules
Siegel, Amanda P⋅Siegel, Amanda P.⋅Siegel, Amanda P⋅Minner, Daniel E.⋅Minner, Daniel E⋅Minner, Daniel E⋅Murcia, Michael J.⋅Murcia, Michael J⋅Murcia, Michael J⋅Elmendorf, Jeffrey S⋅Elmendorf, Jeffrey S.⋅Elmendorf, Jeffrey S⋅Ritchie, Kenneth⋅Ritchie, Kenneth⋅Ritchie, Kenneth⋅Naumann, Christoph A⋅Naumann, Christoph A. and Naumann, Christoph A
Biophysical Journal, vol. 98, (no. 3), pp. 667, 2010-01-00. | Journal Article
 
RETRACTED: A novel membrane-based anti-diabetic action of atorvastatin
Horvath, Emily M⋅Tackett, Lixuan and Elmendorf, Jeffrey S
Biochemical and Biophysical Research Communications, vol. 401, (no. 2), pp. 319, 2010-10-15. | Journal Article
2009
Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin.
Bhonagiri, P.⋅Bhonagiri, P.⋅Bhonagiri, Padma⋅Pattar, G.R.⋅Pattar, Guruprasad R⋅Pattar, G.R.⋅Horvath, E.M.⋅Horvath, E.M.⋅Horvath, Emily M⋅Habegger, K.M.⋅Habegger, Kirk M⋅Habegger, K.M.⋅McCarthy, A.M.⋅McCarthy, A.M.⋅McCarthy, Alicia M⋅Elmendorf, J.S.⋅Elmendorf, Jeffrey S and Elmendorf, J.S.
Endocrinology, vol. 150, (no. 4), pp. 1636-45, 2009/Apr. | Journal Article
2008
A novel membrane-based anti-diabetic action of atorvastatin.
Horvath, Emily M⋅Tackett, Lixuan and Elmendorf, Jeffrey S
Biochemical and biophysical research communications, vol. 372, (no. 4), pp. 639-43, 2008/Aug/8. | Journal Article
 
Antidiabetogenic effects of chromium mitigate hyperinsulinemia-induced cellular insulin resistance via correction of plasma membrane cholesterol imbalance.
Horvath, Emily M⋅Tackett, Lixuan⋅McCarthy, Alicia M⋅Raman, Priya⋅Brozinick, Joseph and Elmendorf, Jeffrey S
Molecular endocrinology (Baltimore, Md.), vol. 22, (no. 4), pp. 937-50, 2008/Apr. | Journal Article
2007
"Actin"g on GLUT4: membrane & cytoskeletal components of insulin action.
Brozinick, Joseph⋅Berkemeier, Bradley A and Elmendorf, Jeffrey S
Current diabetes reviews, vol. 3, (no. 2), pp. 111-22, 2007/May. | Journal Article