1. Injured renal cells generate a stress response that enables them to recover andsurvive. We are characterizing the molecular steps involved in the stress response ofrenal cells. The ultimate objective is to develop therapies that enhance the stressresponse of injured renal cells.
  2. We found two major adaptations of glucose transporting epithelia in diabetes: (1)greater surface area and (2) more glucose transporters. We are now looking at themolecular biology of these epithelial adaptations to diabetes. The ultimate goal is todesign therapies that interfere with these adaptations. We will then determine theirprotective role in renal disease of diabetes.
Past Affiliations

Professor Emeritus, Division of Nephrology, Department of Medicine, Indiana University School of Medicine

Cell Signaling and Communication

Department of Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

MD, Universidad Nacional Autónoma de México, Mexico, 1970
BA, 1962
usa, midwest digestive system diabetes digestive diseases and disorders kidney disease dialysis immunosuppression immunotherapy gene products membranes gene regulation nephrology urology kidney (renal) functions biochemistry & molecular biology ribonucleic acid, rna