The overall focus of my laboratory over more than 20 years has been on understanding the transcriptional regulation of T helper cells as they regulate inflammatory immunity.
My laboratory’s multi-level approach, performing hard-core studies on transcription factor-dependent gene regulation, defining transcription factor-mediated changes in cell function in vitro and in vivo, and ultimately showing conservation in human samples and where possible, linkage to human disease, continues to be a strength in our studies.
Our laboratory focuses broadly on understanding the transcriptional regulation of T helper cell differentiation and the regulation of inflammation by effector T helper subsets.
Research:
- STAT proteins in regulation of inflammation
- IL-9 immunobiology
- Allergic disease
