Research Areas:

  • Cellular & Molecular | Developmental Neurobiology

 My research is focused on the genetics and epigenetics of alcoholism including fetal alcohol spectrum disorders (FASD). In recent years, my research team have taken on the Neuroepigenetics mechanismof FASD by studying intrinsic DNA methylation program during brain development in response to prenatal alcohol exposure. We are analyzing neural development and defects at molecular and chromatic levels using high throughput analysis of DNA methylation and histone modification. 

The second focus of my current research is to investigate how familial drinking preference are carried across generations through genetic and reinforced by epigenetic mechanisms using high and low drinking rat model HAD/LAD line and P/NP line.

We are currently investigating the second arm of the genetics of alcoholism by looking into DMRs through inheritance and alcohol-induction using methyl-sequencing analysis.


  • Addiction Research
  • Neurodegenerative Disorders Research
  • Spinal Cord and Brain Injury Research
Neuroscience, Human Anatomy, Cell Biology, Psychology
PhD, City University of New York, Neuroanatomy, 1983
MPH, City University of New York, Biomedicine, 1982
MPhil, City University of New York, Anatomy, 1981
BS, National Taiwan Normal University, Biology, 1975
alcohol or alcoholism drugs or drug abuse image processing brain fetus nervous system central nervous system craniofacial disorders developmental disabilities mental health mental disorders neurological disorders spinal cord injury parkinson's disease fetal alcohol syndrome mental health services cell culture molecular cellular entities stem cells physiological or development process neuroanatomy neuropharmacology dopamine confocal microscopy
Chinese, Hakka, Chinese, Mandarin, English

Current Neurovascular Research (Editorial Board Member), 2003-2006

Editorial Board Member (Experimental Neurology), 2000-2002

American Society for Neural Transplantation and Repair
International Brain Research Organization
International Society of Biomedical Research on Alcoholism
Research Society of Alcoholism
Serotonin Club
Society for Chinese Bioscientists in North America
Society for Neuroscience