The mechanism of action of interferon, cancer gene therapy with adenovirus and adeno-associated virus vectors carrying the interferon genes and the genes of other cytokines, and identification of specific tumor markers using PCR and DNA array. Cell culture techniques. I have taught cell culture and virology lab and lecture for the last 25 years;
Gene therapy using adenovirus
Molecular Biology, particularly of viruses and RNA
Interferon : mode of action. Interaction with other cytokines
Role of Indoleamine 2,3 dioxygenase in the interferon response and in immunity
DNA micro-arrays ( affymetrix)
Research into hepatitis C, and clinical response to treatment
Cell culture techniques. I have taught cell culture and virology lab and lecture for the last 25 years;
Gene therapy using adenovirus
Molecular Biology, particularly of viruses and RNA
Interferon : mode of action. Interaction with other cytokines
Role of Indoleamine 2,3 dioxygenase in the interferon response and in immunity
DNA micro-arrays ( affymetrix)
Research into hepatitis C, and clinical response to treatment
Gene Therapy with Adenovirus
Somatic cell genetics
Purine metabolism
Biology, Cellular, Biotechnology, Birth/Congenital Defects, Dengue Virus, Disease Entities/Medical Problems, Behavior, Genetic Manipulation, Hepatitis C, Immunology, Immunotherapy, Interferons, Metabolic Diseases
Have worked at Amgen in licensing and administration
Consultant for NGI. Have been consultant for other companies
DNA microarrays may identify novel genes of clinical use
Perform DNA microarrays and cytokine assays to examine differential responses to interferontherapy in hepatitis C patients
Synergy between interferon gamma and interferon alpha