Expertise

Our research encompasses experimental approaches at all levels – clinical, whole animal, organ, tissue, cell, and molecular. Our clinical study in human diabetics on intravascular ultrasound imaging of coronary atherosclerosis guides our studies in swine that superbly mimic human atherosclerosis. We primarily study ion transport adaptations in cardiac and vascular endothelial and smooth muscle cells after several in vivo manipulations: 1) exercise training, 2) dyslipidemia, 3) metabolic syndrome (“pre-diabetes”), and 4) diabetes. Each condition requires chronic treatment of intact animals and study of isolated tissues and single cells from these animals.

Research Interests:

  • Cellular and molecular mechanisms for in vivo cardiovascular phenomena
  • Ion transport adaptations in vascular endothelial and smooth muscle cells
  • Diabetes-induced coronary artery disease
  • Hyperlipidemia
  • Exercise training
  • Biomedical imaging

Subject area:

  • Muscle/Bone Crosstalk
  • Lifestyle Modification: Physical Activity and Nutrition

Research: Complication of Diabetes and Obesity

Past Affiliations

Member, Center for Diabetes and Metabolic Diseases, Centers and Institutes, Indiana University School of Medicine

Department Chair, Department of Cellular and Integrative Physiology, Indiana University School of Medicine

Professor, Department of Cellular and Integrative Physiology, Indiana University School of Medicine

Professor, Krannert Institute of Cardiology, Department of Medicine, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Professor, Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri-Columbia (past)

Communities
Biomedical Engineering, Human Anatomy, Cell Biology
Degrees
PhD, University of Iowa, Pharmacology, 1985
MS, Purdue University, Exercise Physiology, 1980
BA, Augustana College, Exercise Physiology, Psychology, 1979
Keywords
cardiovascular system electrophysiology blood diseases pulmonary diseases respiratory diseases exercise disease model cardiology cardiopulmonary chest medicine