Our research encompasses experimental approaches at all levels – clinical, whole animal, organ, tissue, cell, and molecular. Our clinical study in human diabetics on intravascular ultrasound imaging of coronary atherosclerosis guides our studies in swine that superbly mimic human atherosclerosis. We primarily study ion transport adaptations in cardiac and vascular endothelial and smooth muscle cells after several in vivo manipulations: 1) exercise training, 2) dyslipidemia, 3) metabolic syndrome (“pre-diabetes”), and 4) diabetes. Each condition requires chronic treatment of intact animals and study of isolated tissues and single cells from these animals.
Research Interests:
- Cellular and molecular mechanisms for in vivo cardiovascular phenomena
- Ion transport adaptations in vascular endothelial and smooth muscle cells
- Diabetes-induced coronary artery disease
- Hyperlipidemia
- Exercise training
- Biomedical imaging
Subject area:
- Muscle/Bone Crosstalk
- Lifestyle Modification: Physical Activity and Nutrition
Research: Complication of Diabetes and Obesity
