75 Publications (Page 1 of 3)
A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1
Das, DebanuDas, DebanuDuncton, Matthew AGeorgiadis, Taxiarchis MPellicena, PatriciaClark, JenniferSobol, Robert WGeorgiadis, Millie MKing-Underwood, JohnJobes, David VChang, CalebGao, YangDeacon, Ashley M and WilsonIII, David M
International Journal of Molecular Sciences, vol. 24, (no. 23), 2023. | Journal Article
Building better enzymes: Molecular basis of improved non‐natural nucleobase incorporation by an evolved DNA polymerase
Ouaray, ZahraSingh, IshaGeorgiadis, Millie M and Richards, Nigel G. J
Protein Science, vol. 29, (no. 2), pp. 468, February 2020. | Journal Article
Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1
Trilles, RichardTrilles, RichardBeglov, DmitriBeglov, DmitriChen, QiujiaChen, QiujiaHe, HongzhenHe, HongzhenWireman, RandallWireman, RandallReed, AprilReed, AprilChennamadhavuni, SpandanChennamadhavuni, SpandanPanek, James SPanek, James SBrown, Lauren EBrown, Lauren EVajda, SandorVajda, SandorPorco, Jr, John APorco, Jr, John AKelley, Mark RKelley, Mark RGeorgiadis, Millie M and Georgiadis, Millie M
Journal of medicinal chemistry, vol. 62, (no. 4), pp. 1988, 2019-02-28. | Journal Article
Hachimoji DNA and RNA: A genetic system with eight building blocks
Hoshika, ShuichiLeal, Nicole AKim, Myong-JungKim, Myong-SangKaralkar, Nilesh BKim, Hyo-JoongBates, Alison MWatkins, Jr, Norman ESantaLucia, Holly AMeyer, Adam JDasGupta, SaurjaPiccirilli, Joseph AEllington, Andrew DSantaLucia, Jr, JohnGeorgiadis, Millie M and Benner, Steven A
Science (New York, N.Y.), vol. 363, (no. 6429), pp. 887, 2019-02-22. | Journal Article
"Skinny" and "Fat" DNA: Two New Double Helices.
Hoshika, ShuichiSingh, IshaSwitzer, ChristopherMolt, Robert WLeal, Nicole AKim, Myong-JungKim, Myong-SangKim, Hyo-JoongGeorgiadis, Millie M and Benner, Steven A
Journal of the American Chemical Society, September 10, 2018. | Journal Article
Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide.
Singh, IshaLaos, RobertoHoshika, ShuichiBenner, Steven A and Georgiadis, Millie M
Nucleic acids research, July 9, 2018. | Journal Article
Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulations
Molt, Jr, Robert WGeorgiadis, Millie M and Richards, Nigel G J
Nucleic acids research, vol. 45, (no. 7), pp. 3653, 2017-04-20. | Journal Article
Structure and Biophysics for a Six Letter DNA Alphabet that Includes Imidazo[1,2‑a]‑1,3,5-triazine-2(8H)‑4(3H)‑dione (X) and 2,4-Diaminopyrimidine (K)
Singh, IshaKim, Myong-JungMolt, Robert WHoshika, ShuichiBenner, Steven A and Georgiadis, Millie M
ACS Synthetic Biology, vol. 6, (no. 11), pp. 2129, 20171117. | Journal Article
Toward an Expanded Genome: Structural and Computational Characterization of an Artificially Expanded Genetic Information System
Richards, Nigel G. J and Georgiadis, Millie M
Accounts of Chemical Research, vol. 50, (no. 6), pp. 1382, 20170620. | Journal Article
Crystallization of and selenomethionine phasing strategy for a SETMAR–DNA complex
Chen, Qiujia and Georgiadis, Millie
Acta Crystallographica Section F, vol. 72, (no. 9), pp. 719, September 2016. | Journal Article
Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons
Georgiadis, Millie MGeorgiadis, Millie MChen, QiujiaChen, QiujiaMeng, JingweiMeng, JingweiGuo, ChunluGuo, ChunluWireman, RandallWireman, RandallReed, AprilReed, AprilVasko, Michael RVasko, Michael RKelley, Mark R and Kelley, Mark R
DNA Repair, vol. 41, pp. 41, May 2016. | Journal Article
Crystal structures of GCN2 C-terminal domain: Insight into GCN2 regulation
Singh, IshaHe, HongzhenWek, ShereeDey, SouvikBaird, ThomasWek, Ronald and Georgiadis, Millie
Acta Crystallographica Section A Foundations and Advances, vol. 70, (no. a1), pp. C1407, 2014-08-05. | Journal Article
Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals
He, HongzhenHe, HongzhenSingh, IshaSingh, IshaWek, Sheree AWek, Sheree ADey, SouvikDey, SouvikBaird, Thomas DBaird, Thomas DWek, Ronald CWek, Ronald CGeorgiadis, Millie M and Georgiadis, Millie M
The Journal of biological chemistry, vol. 289, (no. 21), pp. 15034, 2014-May-23. | Journal Article
High-Resolution Crystal Structures Reveal Plasticity in the Metal Binding Site of Apurinic/Apyrimidinic Endonuclease I
He, HongzhenChen, Qiujia and Georgiadis, Millie M
Biochemistry, vol. 53, (no. 41), pp. 6529, 20141021. | Journal Article
Preliminary crystallographic analysis of SETMAR bound to DNA
Chen, QiujiaLee, Suk-Hee and Georgiadis, Millie
Acta Crystallographica Section A Foundations and Advances, vol. 70, (no. a1), pp. C206, 2014-08-05. | Journal Article
The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart.
Kim, Hyun-SukChen, QiujiaKim, Sung-KyungNickoloff, Jac AHromas, RobertGeorgiadis, Millie M and Lee, Suk-Hee
The Journal of biological chemistry, vol. 289, (no. 15), pp. 10930-8, 2014/Apr/11. | Journal Article
The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition
Singh, IshaSingh, IshaJian, YajunLian, YajunLi, LeiLian, YajunLi, LeiGeorgiadis, Millie M and Georgiadis, Millie M
Acta Crystallographica Section D, vol. 70, (no. 3), pp. 759, March 2014. | Journal Article
The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition. Corrigendum
Singh, IshaJian, YajunLi, Lei and Georgiadis, Millie M
Acta Crystallographica Section D, vol. 70, (no. 4), pp. 1173, April 2014. | Journal Article
Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.
Zhang, JunZhang, JunLuo, MeihuaLuo, MeihuaMarasco, DanielaMarasco, DanielaLogsdon, DerekLogsdon, DerekLa Favers, Kaice ALafavers, Kaice AChen, QiujiaChen, QiujiaReed, AprilReed, AprilKelley, MarkKelley, Mark RGross, Michael LGross, Michael LGeorgiadis, Millie M and Georgiadis, Millie M
Biochemistry, vol. 52, (no. 17), pp. 2955-66, 2013/Apr/30. | Journal Article
APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.
Kelley, MarkKelley, Mark RGeorgiadis, Millie MGeorgiadis, Millie MFishel, Melissa L and Fishel, Melissa L
Current molecular pharmacology, vol. 5, (no. 1), pp. 36-53, 2012/Jan. | Journal Article
APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1
Kelley, MarkKelley, MarkKelley, MarkGeorgiadis, MillieGeorgiadis, MillieGeorgiadis, MillieFishel, MelissaFishel, Melissa and Fishel, Melissa
Current Molecular Pharmacology, vol. 5, (no. 1), pp. 53, 2012-January. | Journal Article
Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.
Luo, MeihuaZhang, JunHe, HongzhenSu, DianChen, QiujiaGross, Michael LKelley, Mark and Georgiadis, Millie M
Biochemistry, vol. 51, (no. 2), pp. 695-705, 2012/Jan/17. | Journal Article
Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii
Onyango, David ONaguleswaran, ArunasalamDelaplane, SarahReed, AprilKelley, Mark RGeorgiadis, Millie M and Sullivan, William J
DNA Repair, vol. 10, (no. 5), pp. 466-475, 2011. | Journal Article
Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1
Kelley, Mark RLuo, M.Reed, A.Su, D.Delaplane, S.Borch, Rich FNyland, RL IGross, Michael L and Georgiadis, Millie M
Antioxidants and Redox Signaling, vol. 14, (no. 8), pp. 1387-1401, 2011. | Journal Article
Interactions of apurinic/apyrimidinic endonuclease with aoxidative half-reaction : evidence for an alternate conformation of the enzyme
Su, DianSu, DianVu, BichVu, BichKelley, MarkKelley, MarkGross, MichaelGross, MichaelGeorgiadis, MillieGeorgiadis, MillieDelaplane, SarahDelaplane, SarahLuo, MeihuaLuo, MeihuaRempel, Don and Rempel, Don
Biochemistry, vol. 50, (no. 1), pp. 82, 20110111. | Journal Article