65 Publications (Page 1 of 3)
2013
Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
Gangjee, Aleem⋅Namjoshi, Ojas A⋅Raghavan, Sudhir⋅Queener, Sherry F⋅Kisliuk, Roy L and Cody, Vivian
Journal of medicinal chemistry, vol. 56, (no. 11), pp. 4422-41, 2013/Jun/13. | Journal Article
 
Inhibitors of eIF2 alpha Dephosphorylation Slow Replication and Stabilize Latency in Toxoplasma gondii
Konrad, Christian⋅Queener, Sherry F⋅Wek, Ronald and Sullivan, William J
Antimicrobial Agents & Chemotherapy, vol. 57, (no. 4), pp. 1815-1822, 2013. | Journal Article
 
Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.
Konrad, Christian⋅Queener, Sherry F⋅Wek, Ronald C and Sullivan, William J
Antimicrobial agents and chemotherapy, vol. 57, (no. 4), pp. 1815-22, 2013/Apr. | Journal Article
 
Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants
Cody, Vivian⋅Pace, Jim⋅Queener, Sherry F⋅Adair, Ona O and Gangjee, Aleem
Antimicrobial Agents & Chemotherapy, vol. 57, (no. 6), pp. 2669-2677, 2013. | Journal Article
 
Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii.
Queener, Sherry F⋅Cody, Vivian⋅Pace, J⋅Torkelson, P and Gangjee, A
Antimicrobial agents and chemotherapy, vol. 57, (no. 10), pp. 4990-8, 2013/Oct. | Journal Article
2011
Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.
Cody, Vivian⋅Pace, Jim⋅Piraino, Jennifer and Queener, Sherry F
Journal of structural biology, vol. 176, (no. 1), pp. 52-9, 2011/Oct. | Journal Article
2010
2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.
Gangjee, Aleem⋅Jain, Hiteshkumar D⋅Phan, Jaclyn⋅Guo, Xin⋅Queener, Sherry F and Kisliuk, Roy L
Bioorganic & medicinal chemistry, vol. 18, (no. 2), pp. 953-61, 2010/Jan/15. | Journal Article
 
CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application.
Gangjee, Aleem⋅Lin, Xin⋅Biondo, Lisa R and Queener, Sherry F
Bioorganic & medicinal chemistry, vol. 18, (no. 4), pp. 1684-701, 2010/Feb/15. | Journal Article
 
Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens.
Bag, Seema⋅Tawari, Nilesh R⋅Degani, Mariam S and Queener, Sherry F
Bioorganic & medicinal chemistry, vol. 18, (no. 9), pp. 3187-97, 2010/May/1. | Journal Article
 
Phosphorylation of eukaryotic initiation factor-2[alpha] promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii
Joyce, Bradley R⋅Queener, Sherry F⋅Wek, Ronald and Sullivan, William J
Proceedings of the National Academy of Sciences of the United States of America, vol. 107, (no. 40), Oct 5, 2010. | Journal Article
 
Phosphorylation of eukaryotic initiation factor-2a promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii
Joyce, Bradley R⋅Queener, Sherry F⋅Wek, Ronald and Sullivan, William J
Proceedings of the National Academy of Sciences, USA, vol. 107, (no. 40), pp. 17200-17205, 2010. | Journal Article
 
Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms.
Bag, Seema⋅Tawari, Nilesh R⋅Queener, Sherry F and Degani, Mariam S
Journal of enzyme inhibition and medicinal chemistry, vol. 25, (no. 3), pp. 331-9, 2010/Jun. | Journal Article
2009
Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.
Cody, Vivian⋅Pace, Jim⋅Makin, Jennifer⋅Piraino, Jennifer⋅Queener, Sherry F and Rosowsky, Andre D
Biochemistry, vol. 48, (no. 8), pp. 1702-11, 2009/Mar/3. | Journal Article
 
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors
Gangjee, Aleem⋅Li, Wei⋅Lin, Lu⋅Zeng, Yibin⋅Ihnat, Michael⋅Warnke, Linda A⋅Green, Dixy W⋅Cody, Vivian⋅Pace, Jim and Queener, Sherry F
Bioorganic and Medicinal Chemistry, vol. 17, (no. 20), pp. 7324-7336, 2009. | Journal Article
 
Selective Antifolates for Chemically Labeling Proteins in Mammalian Cells
Pedró Rosa, Laura E⋅Reddy, D. R⋅Queener, Sherry F and Miller, Lawrence W
Chembiochem., vol. 10, (no. 9), pp. 1462-1464, 2009. | Journal Article
2008
N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.
Gangjee, Aleem⋅Adair, Ona O⋅Pagley, Michelle and Queener, Sherry F
Journal of medicinal chemistry, vol. 51, (no. 19), pp. 6195-200, 2008/Oct/9. | Journal Article
 
Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo.
Mui, Ernest J⋅Schiehser, Guy A⋅Milhous, Wilbur⋅Hsu, Honghue⋅Roberts, Craig⋅Kirisits, Michael⋅Muench, Stephen⋅Rice, David⋅Dubey, J P⋅Fowble, Joseph W⋅Rathod, Pradipsinh K⋅Queener, Sherry F⋅Liu, Susan R⋅Jacobus, David P and McLeod, Rima
PLoS neglected tropical diseases, vol. 2, (no. 3), pp. e190, 2008. | Journal Article
 
Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo
Mui, Ernest J⋅Mui, Ernest J⋅Mui, Ernest J⋅Schiehser, Guy A⋅Schiehser, Guy A⋅Schiehser, Guy A⋅Milhous, Wilbur K⋅Milhous, Wilbur⋅Milhous, Wilbur K⋅Hsu, Honghue⋅Hsu, Honghue⋅Hsu, Honghue⋅Roberts, Craig⋅Roberts, Craig W⋅Roberts, Craig W⋅Kirisits, Michael⋅Kirisits, Michael⋅Kirisits, Michael⋅Muench, Stephen⋅Muench, Stephen⋅Muench, Stephen⋅Rice, David⋅Rice, David⋅Rice, David⋅Dubey, JP⋅Dubey, J P⋅Dubey, J.P.⋅Fowble, Joseph W⋅Fowble, Joseph W⋅Fowble, Joseph W⋅Rathod, Pradipsinh K⋅Rathod, Pradipsinh K⋅Rathod, Pradipsinh K⋅Queener, Sherry F⋅Queener, Sherry F⋅Queener, Sherry F⋅Liu, Susan R⋅Liu, Susan R⋅Liu, Susan R⋅Jacobus, David P⋅Jacobus, David P⋅Jacobus, David P⋅McLeod, Rima⋅Mc Leod, Rima and McLeod, Rima
PLoS neglected tropical diseases., 2008. | Journal Article
 
Recombinant bovine dihydrofolate reductase produced by mutagenesis and nested PCR of murine dihydrofolate reductase cDNA
Cody, Vivian⋅Mao, Qilong and Queener, Sherry F
Protein Expression and Purification, vol. 62, (no. 1), pp. 104-110, 2008. | Journal Article
 
The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
Gangjee, Aleem⋅Jain, Hiteshkumar D⋅Queener, Sherry F and Kisliuk, Roy L
Journal of medicinal chemistry, vol. 51, (no. 15), pp. 4589-600, 2008/Aug/14. | Journal Article
2007
Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.
Gangjee, Aleem⋅Zeng, Yibin⋅Talreja, Tina⋅Mc Guire, John⋅Kisliuk, Roy L and Queener, Sherry F
Journal of medicinal chemistry, vol. 50, (no. 13), pp. 3046-53, 2007/Jun/28. | Journal Article
 
Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation
Reynolds, RC⋅Campbell, S. R⋅Fairchild, RG⋅Kisliuk, Roy L⋅Micca, PL⋅Queener, Sherry F⋅Riordan, JM⋅Sedwick, WD⋅Waud, WR⋅Leung, AKW⋅Dixon, RW⋅Suling, WJ and Borhani, DW
Journal of Medicinal Chemistry, vol. 50, (no. 14), pp. 3283-3289, 2007. | Journal Article
 
Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii
Smith, Aaron T⋅Livingston, Meredith R⋅Mai, Antonello⋅Filetici, Patrizia⋅Queener, Sherry F and Sullivan, William J
Antimicrobial Agents & Chemotherapy, vol. 51, (no. 3), pp. 1109-1111, 2007. | Journal Article
2006
Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3- d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents
Gangjee, Aleem⋅Yang, Jie and Queener, Sherry F
Bioorganic and Medicinal Chemistry, vol. 14, (no. 24), pp. 8341-8351, 2006. | Journal Article
2005
Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
Chan, David C⋅Fu, Hongning⋅Forsch, Ronald A⋅Queener, Sherry F and Rosowsky, Andre
Journal of medicinal chemistry, vol. 48, (no. 13), pp. 4420-31, 2005/Jun/30. | Journal Article