Expertise

The laboratory focuses on mechanisms regulating proliferation, survival, self-renewal, metabolism, differentiation and homing/mobilization of hematopoietic, embryonic, and induced pluripotent stem cells at cellular, intracellular, and animal levels, as well as gene transfer, to influence these functions.

Dr. Broxmeyer's laboratory is interested in blood cell production (hematopoiesis) in the context of normal and abnormal cell regulation as assessed in vitro and in vivo.

Dr. Broxmeyer's research interests include:

  • Study of the mechanisms regulating blood cell production (hematopoiesis) of normal and abnormal cell regulation as assessed in vitro and in vivo at the level of proliferation/self-enewal/differentiation/apoptosis and homing/migration of hematopoietic stem and progenitor cells, as well as regulation in the context of oxygen tension and the microenvironment, and generation of induced pluripotent stem cells.
Past Affiliations

Co-Leader, Melvin and Bren Simon Cancer Center, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Professor, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Professor, Cancer Research, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Chairman, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Professor, Immunology, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Professor, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Professor, Gene Transfer/Gene Therapy, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Mary Margaret Walther Professor, Cancer Research, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Chairman, Cancer Research, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Division of Hematology/Oncology, Department of Medicine, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Co-Leader, Immunology, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Distinguished Professor, Immunology, Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Director, Walther Oncology Center

Communities
Oncology, Infectious Diseases and Immunology, Immunology, Microbiology
Degrees
PhD, New York University, 1973
MS, Long Island University Brooklyn Campus, 1969
BS, Brooklyn College, The City University of New York, 1966
Keywords
flow cytometry bone marrow cardiovascular system drug metabolism radioimmunoassay blood diseases pulmonary diseases respiratory diseases gene therapy molecular cloning recombinant dna cell cycle gene expression cardiology cardiopulmonary chest medicine cell differentiation phenotype macrophage iron