Expertise

A second research focus in the lab is on the role the inflammatory response plays in the development of ovarian cancer.

Research Interests:

  • Elucidation of cellular and molecular mechanisms used to achieve specificity in growth factor/cytokine-specific changes in gene expression
  • Pathophysiology associated with chronic non-infectious inflammatory diseases, cardiovascular diseases, diabetes and certain cancers
  • Interleukin-1 signaling using basic cell biology and genetic approaches
  • Functional significance of mPLK/IRAK-1 in the context of TNF(alpha) signaling and development of cancers
  • Determination of the molecular mechanism through which SIMPL mediates the synergistic enhancement of p65 activity
Past Affiliations

Adjunct Faculty, Department of Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Professor, Department of Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Professor, Melvin and Bren Simon Cancer Center, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Melvin and Bren Simon Cancer Center, Indiana University-Purdue University Indianapolis, School of Medicine (past)
current

Communities
Biochemistry, Molecular Biology, Oncology, Cellular Biochemistry, Physiology, Molecular Biochemistry
Degrees
PhD, University of North Carolina at Chapel Hill, Pharmacology, 1985
MS, University of Texas School of Public Health in Dallas, Population Studies, 1980
BS, Purdue University, Nutritional Sciences, 1978
Keywords
bone marrow connective tissue endocrine system fetus mechanism of action (medical) cell & developmental biology biochemistry & molecular biology biochemistry, proteins