10 Publications
2021
‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues
Jarosinski, Mark A.⋅Jarosinski, Mark A.⋅Dhayalan, Balamurugan⋅Dhayalan, Balamurugan⋅Rege, Nischay⋅Rege, Nischay⋅Chatterjee, Deepak⋅Chatterjee, Deepak⋅Weiss, Michael A. and Weiss, Michael A.
Diabetologia, vol. 64, (no. 5), pp. 1029, 2021-05-01. | Journal Article
2019
Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin
Weil‐Ktorza, Orit⋅Rege, Nischay⋅Lansky, Shifra⋅Shalev, Deborah E.⋅Shoham, Gil⋅Weiss, Michael A. and Metanis, Norman
Chemistry : a European journal, vol. 25, (no. 36), pp. 8521, June 26, 2019. | Journal Article
2018
An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein
Glidden, Michael D⋅Glidden, Michael D.⋅Aldabbagh, Khadijah⋅Aldabbagh, Khadijah⋅Phillips, Nelson B.⋅Phillips, Nelson B⋅Carr, Kelley⋅Carr, Kelley⋅Chen, Yen-Shan⋅Chen, Yen-Shan⋅Whittaker, Jonathan⋅Whittaker, Jonathan⋅Phillips, Manijeh⋅Phillips, Manijeh⋅Wickramasinghe, Nalinda P.⋅Wickramasinghe, Nalinda P⋅Rege, Nischay⋅Rege, Nischay⋅Swain, Mamuni⋅Swain, Mamuni⋅Peng, Yi⋅Peng, Yi⋅Yang, Yanwu⋅Yang, Yanwu⋅Lawrence, Michael C.⋅Lawrence, Michael C⋅Yee, Vivien C⋅Yee, Vivien C.⋅Ismail-Beigi, Faramarz⋅Ismail-Beigi, Faramarz⋅Weiss, Michael A and Weiss, Michael A.
The Journal of biological chemistry, vol. 293, (no. 1), pp. 68, 2018-01-05. | Journal Article
 
Biosynthesis, structure, and folding of the insulin precursor protein
Liu, Ming⋅Weiss, Michael A.⋅Arunagiri, Anoop⋅Yong, Jing⋅Rege, Nischay⋅Sun, Jinhong⋅Haataja, Leena⋅Kaufman, Randal J. and Arvan, Peter
Diabetes, obesity & metabolism, vol. 20, (no. S2), pp. 50, September 2018. | Journal Article
 
Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic–aromatic interactions
Rege, Nischay K⋅Rege, Nischay K.⋅Wickramasinghe, Nalinda P⋅Wickramasinghe, Nalinda P.⋅Tustan, Alisar N.⋅Tustan, Alisar N⋅Phillips, Nelson F.B.⋅Phillips, Nelson F B⋅Yee, Vivien C.⋅Yee, Vivien C⋅Ismail-Beigi, Faramarz⋅Ismail-Beigi, Faramarz⋅Weiss, Michael A. and Weiss, Michael A
The Journal of biological chemistry, vol. 293, (no. 28), pp. 10910, 2018-07-13. | Journal Article
2017
Development of glucose-responsive ‘smart’ insulin systems
Rege, Nischay K⋅Rege, Nischay K⋅Phillips, Nelson F B⋅Phillips, Nelson F B⋅Weiss, Michael A and Weiss, Michael A
Current opinion in endocrinology, diabetes, and obesity, vol. 24, (no. 4), pp. 278, 2017-Aug. | Journal Article
 
Glucose-responsive insulin by molecular and physical design
Bakh, Naveed A⋅Bakh, Naveed A⋅Bakh, Naveed A⋅Bakh, Naveed A⋅Cortinas, Abel B⋅Cortinas, Abel B⋅Cortinas, Abel B⋅Cortinas, Abel B⋅Weiss, Michael A⋅Weiss, Michael A⋅Weiss, Michael A⋅Weiss, Michael A⋅Langer, Robert S⋅Langer, Robert S⋅Langer, Robert S⋅Langer, Robert S⋅Anderson, Daniel G⋅Anderson, Daniel G⋅Anderson, Daniel G⋅Anderson, Daniel G⋅Gu, Zhen⋅Gu, Zhen⋅Gu, Zhen⋅Gu, Zhen⋅Dutta, Sanjoy⋅Dutta, Sanjoy⋅Dutta, Sanjoy⋅Dutta, Sanjoy⋅Strano, Michael S⋅Strano, Michael S⋅Strano, Michael S and Strano, Michael S
Nature chemistry, vol. 9, (no. 10), pp. 944, 2017-09-22. | Journal Article
 
Scope and Limitations of Fmoc Chemistry SPPS‐Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin
Dhayalan, Balamurugan⋅Kent, Stephen⋅Mandal, Kalyaneswar⋅Dhayalan, Balamurugan⋅Mandal, Kalyaneswar⋅Rege, Nischay⋅Weiss, Michael A.⋅Rege, Nischay⋅Weiss, Michael⋅Eitel, Simon H.⋅Eitel, Simon⋅Meier, Thomas⋅Meier, Thomas⋅Schoenleber, Ralph O.⋅Kent, Stephen B. H. and Schoenleber, Ralph
Chemistry : a European journal, vol. 23, (no. 7), pp. 1716, January 31, 2017. | Journal Article
2016
Contribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE
Pandyarajan, Vijay⋅Phillips, Nelson B⋅Rege, Nischay⋅Lawrence, Michael C⋅Whittaker, Jonathan and Weiss, Michael A
The Journal of biological chemistry, vol. 291, (no. 25), pp. 12990, 2016-Jun-17. | Journal Article
 
Efficient Total Chemical Synthesis of (13) C=(18) O Isotopomers of Human Insulin for Isotope-Edited FTIR
Dhayalan, Balamurugan⋅Dhayalan, Balamurugan⋅Fitzpatrick, Ann⋅Fitzpatrick, Ann⋅Mandal, Kalyaneswar⋅Mandal, Kalyaneswar⋅Whittaker, Jonathan⋅Whittaker, Jonathan⋅Weiss, Michael A⋅Weiss, Michael A⋅Tokmakoff, Andrei⋅Tokmakoff, Andrei⋅Kent, Stephen B H and Kent, Stephen B H
Chembiochem : a European journal of chemical biology, vol. 17, (no. 5), pp. 420, 2016-Mar-02. | Journal Article