18 Publications
Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.
Goodwin, Charles BYang, ZhenyunYin, FuqinYu, Menggang and Chan, Rebecca
Haematologica, vol. 97, (no. 7), pp. 1042-7, 2012/Jul. | Journal Article
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K
Yang, ZhenyunYang, ZhenyunChen, MiaChen, MiaSitarski, SarahSitarski, Sarah ASaadatzadeh, TirajehSaadatzadeh, TirajehYin, FuqinYin, FuqinYu, MenggangYu, MenggangYang, Feng ChunYang, Feng ChunChan, Rebecca and Chan, Rebecca
Leukemia Research, vol. 35, (no. 7), pp. 961-964, 2011. | Journal Article
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Mali, Raghuveer SMali, Raghuveer SinghRamdas, BaskarRamdas, BaskarMa, PeilinMa, PeilinShi, JianjianShi, JianjianMunugalavadla, VeerendraMunugalavadla, VeerendraSims, EmilySims, EmilyWei, LeiWei, LeiVemula, SasidharVemula, SasidharNabinger, Sarah CNabinger, Sarah CGoodwin, Charles BGoodwin, Charles BChan, RebeccaChan, Rebecca JTraina, FabiolaTraina, FabiolaVisconte, ValeriaVisconte, ValeriaTiu, Ramon VTiu, Ramon VLewis, Timothy ALewis, Timothy AStern, Andrew MStern, Andrew MWen, Qiang JWen, QiangCrispino, John DCrispino, JohnBoswell, H. ScottBoswell, H. SKapur, Reuben and Kapur, Reuben
Cancer cell, vol. 20, (no. 3), pp. 357-69, 2011/Sep/13. | Journal Article
Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: a study of the Hoosier Oncology Group.
Sayar, HamidChan, RebeccaOrschell, Christie MChan, Edward MYu, ZhangshengHood, DanielPlett, ArturYang, ZhenyunHui, Chua LNabinger, Sarah CKohlbacher, Kristopher JWest, Evan SWalter, AmandaSampson, CarolWu, Jingwei and Cripe, Larry D
Leukemia research, vol. 35, (no. 8), pp. 1108-10, 2011/Aug. | Journal Article
Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.
Yang, ZhenyunKondo, TakakoVoorhorst, Cara SNabinger, Sarah CNdong, LeilaYin, FuqinChan, Edward MYu, MenggangWürstlin, OliverKratz, Christian PNiemeyer, Charlotte MFlotho, ChristianHashino, Eri and Chan, Rebecca
Molecular and cellular biology, vol. 29, (no. 16), pp. 4376-93, 2009/Aug. | Journal Article
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1
Yan, JinchengYan, JinchengChen, ShiChen, ShiZhang, YingzeZhang, YingzeLi, XiaohongLi, XiaohongLi, YanLi, YanWu, XiaohuaWu, XiaohuaYuan, JinYuan, JinRobling, AlexanderRobling, Alexander GKapur, ReubenKapur, ReubenChan, RebeccaChan, Rebecca JYang, Feng Chun and Yang, Feng Chun
Human Molecular Genetics, vol. 17, (no. 12), pp. 1876, Jun 15, 2008. | Journal Article
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Yan, JinchengYan, JinchengChen, ShiChen, ShiZhang, YingzeZhang, YingzeLi, XiaohongLi, XiaohongLi, YanLi, YanWu, XiaohuaWu, XiaohuaYuan, JinYuan, JinRobling, AlexanderRobling, Alexander GKapur, ReubenKarpur, ReubenChan, Rebecca JChan, RebeccaYang, Feng Chun and Yang, Feng Chun
Human molecular genetics, vol. 17, (no. 7), pp. 936-48, 2008/Apr/1. | Journal Article
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
Chan, Rebecca and Feng, Gen Sheng
Blood, vol. 109, (no. 3), pp. 862-7, 2007/Feb/1. | Journal Article
Reduction of Shp-2 Expression by Small Interfering RNA Reduces Murine Embryonic Stem Cell-Derived In Vitro Hematopoietic Differentiation
Zou, Gang-MingChan, RebeccaShelley, WChristopher and Yoder, Mervin C
Stem Cells, vol. 24, (no. 3), pp. 587-594, 2006. | Journal Article
Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal.
Chan, RebeccaLi, YanjunHass, Meredith NWalter, AmandaVoorhorst, Cara SShelley, W CYang, ZhenyunOrschell, Christie M and Yoder, Mervin C
Experimental hematology, vol. 34, (no. 9), pp. 1230-9, 2006/Sep. | Journal Article
Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.
Chan, Rebecca JChan, RebeccaLeedy, Melissa BLeedy, Melissa BMunugalavadla, VeerendraMunugalavadla, VeerendraVoorhorst, Cara SVoorhorst, Cara SLi, YanjunLi, YanjunYu, MenggangYu, MenggangKapur, Reuben and Kapur, Reuben
Blood, vol. 105, (no. 9), pp. 3737-42, 2005/May/1. | Journal Article
Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells.
Zhong, LiLi, WeimingYang, ZuochengQing, KeyunTan, MengqunHansen, JonathanLi, YanjunChen, LinyuanChan, RebeccaBischof, DanielaMaina, NjeriWeigel-Kelley, Kirsten AZhao, WeihongLarsen, Steven HYoder, Mervin CShou, Weinian and Srivastava, Arun
Human gene therapy, vol. 15, (no. 12), pp. 1207-18, 2004/Dec. | Journal Article
Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo.
Zhong, LiChen, LinyuanLi, YanjunQing, KeyunWeigel-Kelley, Kirsten AChan, RebeccaYoder, Mervin C and Srivastava, Arun
Molecular therapy : the journal of the American Society of Gene Therapy, vol. 10, (no. 5), pp. 950-7, 2004/Nov. | Journal Article
A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis.
Chan, RebeccaJohnson, Scott ALi, YanjunYoder, Mervin C and Feng, Gen Sheng
Blood, vol. 102, (no. 6), pp. 2074-80, 2003/Sep/15. | Journal Article
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.
Xie, XiaodongChan, RebeccaJohnson, Scott AStarr, MarkMcCarthy, JenniferKapur, Reuben and Yoder, Mervin C
Blood, vol. 101, (no. 4), pp. 1329-35, 2003/Feb/15. | Journal Article
Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation.
Xie, XiaodongChan, Rebecca and Yoder, Mervin C
FEBS letters, vol. 529, (no. 2-3), pp. 361-4, 2002/Oct/9. | Journal Article
Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis.
Palis, JamesChan, RebeccaKoniski, APatel, RStarr, M and Yoder, Mervin C
Proceedings of the National Academy of Sciences of the United States of America, vol. 98, (no. 8), pp. 4528-33, 2001/Apr/10. | Journal Article
Regulation of preproenkephalin A gene expression (Dissertation)
Chan, Rebecca (1995).