18 Publications
2012
Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.
Goodwin, Charles B⋅Yang, Zhenyun⋅Yin, Fuqin⋅Yu, Menggang and Chan, Rebecca
Haematologica, vol. 97, (no. 7), pp. 1042-7, 2012/Jul. | Journal Article
2011
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K
Yang, Zhenyun⋅Yang, Zhenyun⋅Chen, Mia⋅Chen, Mia⋅Sitarski, Sarah⋅Sitarski, Sarah A⋅Saadatzadeh, Tirajeh⋅Saadatzadeh, Tirajeh⋅Yin, Fuqin⋅Yin, Fuqin⋅Yu, Menggang⋅Yu, Menggang⋅Yang, Feng Chun⋅Yang, Feng Chun⋅Chan, Rebecca and Chan, Rebecca
Leukemia Research, vol. 35, (no. 7), pp. 961-964, 2011. | Journal Article
 
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Mali, Raghuveer S⋅Mali, Raghuveer Singh⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Ma, Peilin⋅Ma, Peilin⋅Shi, Jianjian⋅Shi, Jianjian⋅Munugalavadla, Veerendra⋅Munugalavadla, Veerendra⋅Sims, Emily⋅Sims, Emily⋅Wei, Lei⋅Wei, Lei⋅Vemula, Sasidhar⋅Vemula, Sasidhar⋅Nabinger, Sarah C⋅Nabinger, Sarah C⋅Goodwin, Charles B⋅Goodwin, Charles B⋅Chan, Rebecca⋅Chan, Rebecca J⋅Traina, Fabiola⋅Traina, Fabiola⋅Visconte, Valeria⋅Visconte, Valeria⋅Tiu, Ramon V⋅Tiu, Ramon V⋅Lewis, Timothy A⋅Lewis, Timothy A⋅Stern, Andrew M⋅Stern, Andrew M⋅Wen, Qiang J⋅Wen, Qiang⋅Crispino, John D⋅Crispino, John⋅Boswell, H. Scott⋅Boswell, H. S⋅Kapur, Reuben and Kapur, Reuben
Cancer cell, vol. 20, (no. 3), pp. 357-69, 2011/Sep/13. | Journal Article
 
Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: a study of the Hoosier Oncology Group.
Sayar, Hamid⋅Chan, Rebecca⋅Orschell, Christie M⋅Chan, Edward M⋅Yu, Zhangsheng⋅Hood, Daniel⋅Plett, Artur⋅Yang, Zhenyun⋅Hui, Chua L⋅Nabinger, Sarah C⋅Kohlbacher, Kristopher J⋅West, Evan S⋅Walter, Amanda⋅Sampson, Carol⋅Wu, Jingwei and Cripe, Larry D
Leukemia research, vol. 35, (no. 8), pp. 1108-10, 2011/Aug. | Journal Article
2009
Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.
Yang, Zhenyun⋅Kondo, Takako⋅Voorhorst, Cara S⋅Nabinger, Sarah C⋅Ndong, Leila⋅Yin, Fuqin⋅Chan, Edward M⋅Yu, Menggang⋅Würstlin, Oliver⋅Kratz, Christian P⋅Niemeyer, Charlotte M⋅Flotho, Christian⋅Hashino, Eri and Chan, Rebecca
Molecular and cellular biology, vol. 29, (no. 16), pp. 4376-93, 2009/Aug. | Journal Article
2008
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1
Yan, Jincheng⋅Yan, Jincheng⋅Chen, Shi⋅Chen, Shi⋅Zhang, Yingze⋅Zhang, Yingze⋅Li, Xiaohong⋅Li, Xiaohong⋅Li, Yan⋅Li, Yan⋅Wu, Xiaohua⋅Wu, Xiaohua⋅Yuan, Jin⋅Yuan, Jin⋅Robling, Alexander⋅Robling, Alexander G⋅Kapur, Reuben⋅Kapur, Reuben⋅Chan, Rebecca⋅Chan, Rebecca J⋅Yang, Feng Chun and Yang, Feng Chun
Human Molecular Genetics, vol. 17, (no. 12), pp. 1876, Jun 15, 2008. | Journal Article
 
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Yan, Jincheng⋅Yan, Jincheng⋅Chen, Shi⋅Chen, Shi⋅Zhang, Yingze⋅Zhang, Yingze⋅Li, Xiaohong⋅Li, Xiaohong⋅Li, Yan⋅Li, Yan⋅Wu, Xiaohua⋅Wu, Xiaohua⋅Yuan, Jin⋅Yuan, Jin⋅Robling, Alexander⋅Robling, Alexander G⋅Kapur, Reuben⋅Karpur, Reuben⋅Chan, Rebecca J⋅Chan, Rebecca⋅Yang, Feng Chun and Yang, Feng Chun
Human molecular genetics, vol. 17, (no. 7), pp. 936-48, 2008/Apr/1. | Journal Article
2007
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
Chan, Rebecca and Feng, Gen Sheng
Blood, vol. 109, (no. 3), pp. 862-7, 2007/Feb/1. | Journal Article
2006
Reduction of Shp-2 Expression by Small Interfering RNA Reduces Murine Embryonic Stem Cell-Derived In Vitro Hematopoietic Differentiation
Zou, Gang-Ming⋅Chan, Rebecca⋅Shelley, WChristopher and Yoder, Mervin C
Stem Cells, vol. 24, (no. 3), pp. 587-594, 2006. | Journal Article
 
Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal.
Chan, Rebecca⋅Li, Yanjun⋅Hass, Meredith N⋅Walter, Amanda⋅Voorhorst, Cara S⋅Shelley, W C⋅Yang, Zhenyun⋅Orschell, Christie M and Yoder, Mervin C
Experimental hematology, vol. 34, (no. 9), pp. 1230-9, 2006/Sep. | Journal Article
2005
Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.
Chan, Rebecca J⋅Chan, Rebecca⋅Leedy, Melissa B⋅Leedy, Melissa B⋅Munugalavadla, Veerendra⋅Munugalavadla, Veerendra⋅Voorhorst, Cara S⋅Voorhorst, Cara S⋅Li, Yanjun⋅Li, Yanjun⋅Yu, Menggang⋅Yu, Menggang⋅Kapur, Reuben and Kapur, Reuben
Blood, vol. 105, (no. 9), pp. 3737-42, 2005/May/1. | Journal Article
2004
Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells.
Zhong, Li⋅Li, Weiming⋅Yang, Zuocheng⋅Qing, Keyun⋅Tan, Mengqun⋅Hansen, Jonathan⋅Li, Yanjun⋅Chen, Linyuan⋅Chan, Rebecca⋅Bischof, Daniela⋅Maina, Njeri⋅Weigel-Kelley, Kirsten A⋅Zhao, Weihong⋅Larsen, Steven H⋅Yoder, Mervin C⋅Shou, Weinian and Srivastava, Arun
Human gene therapy, vol. 15, (no. 12), pp. 1207-18, 2004/Dec. | Journal Article
 
Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo.
Zhong, Li⋅Chen, Linyuan⋅Li, Yanjun⋅Qing, Keyun⋅Weigel-Kelley, Kirsten A⋅Chan, Rebecca⋅Yoder, Mervin C and Srivastava, Arun
Molecular therapy : the journal of the American Society of Gene Therapy, vol. 10, (no. 5), pp. 950-7, 2004/Nov. | Journal Article
2003
A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis.
Chan, Rebecca⋅Johnson, Scott A⋅Li, Yanjun⋅Yoder, Mervin C and Feng, Gen Sheng
Blood, vol. 102, (no. 6), pp. 2074-80, 2003/Sep/15. | Journal Article
 
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.
Xie, Xiaodong⋅Chan, Rebecca⋅Johnson, Scott A⋅Starr, Mark⋅McCarthy, Jennifer⋅Kapur, Reuben and Yoder, Mervin C
Blood, vol. 101, (no. 4), pp. 1329-35, 2003/Feb/15. | Journal Article
2002
Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation.
Xie, Xiaodong⋅Chan, Rebecca and Yoder, Mervin C
FEBS letters, vol. 529, (no. 2-3), pp. 361-4, 2002/Oct/9. | Journal Article
2001
Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis.
Palis, James⋅Chan, Rebecca⋅Koniski, A⋅Patel, R⋅Starr, M and Yoder, Mervin C
Proceedings of the National Academy of Sciences of the United States of America, vol. 98, (no. 8), pp. 4528-33, 2001/Apr/10. | Journal Article
1995
Regulation of preproenkephalin A gene expression (Dissertation)
Chan, Rebecca (1995).