I am currently interested in the functional significance of subunit stoichiometry and heterogeneity of a GTP-binding protein named Transducin, a cornerstone of the cyclic nucleotide cascade that underlies our ability to see. I am trying to determine how differences in Transducin stoichiometry affect its function. I am also examining the effect of different post-translational modifications of the beta subunit of Transducin on its function, including its interactions with other subunits, proteins and the photoreceptor disc membrane. I am also collaborating with other investigators in the analysis of proteins as biomarkers for cellular and tissue injury precipitated by environmental stressors.
