The Evans research group is engaged in the exploration and development of reactive intermediates for the expeditious synthesis of complex biologically important natural products. Specifically, we are developing diastereoselective radical cyclizations, temporary silicon-tethered ring-closing metathesis, and a variety of new asymmetric transition-metal catalyzed cross-coupling and carbocyclization reactions.
- Catalysis
- Natural Product Synthesis
- Organic Chemistry
- Organometallic Chemistry
- Synthetic Chemistry
The Evans research group is engaged in the exploration and development of reactive intermediates for the expeditious synthesis of complex biologically important natural products. Specifically, we are developing diastereoselective radical cyclizations, temporary silicon-tethered ring-closing metathesis, and a variety of new asymmetric transition-metal catalyzed cross-coupling and carbocyclization reactions.
The first area of investigation is currently focused on the application of free radical cyclization reactions to the total synthesis of complex biologically important polycyclic guanidine-containing alkaloids.
We are also interested in transition-metal-catalyzed cross-coupling and carbocyclization reactions. In the course of these studies, we were intrigued by the problem of controlling regiochemistry in allylic systems.
