Our laboratory studies factors underlying tissue organization in embryonic development, wound healing, and regeneration. Our primary research projects examine the mechanisms that permit urodele amphibians to regenerate their spinal cords and limbs throughout their lives. We are currently interested in the role of resident stem cells in these processes and the mechanism through which the spinal cord prevents formation of a meningeal/fibrotic scar. We use tissue culture models systems, biochemical and molecular biological techniques to analyze the contributions of the cells, extracellular matrix remodeling and stem cell-related gene expression to amphibian regeneration.
