Dr. John’s research focuses on malaria pathogenesis, immunology and epidemiology.

Key discoveries of his collaborative research team include:

  • 1) the first prospective studies to establish that severe malaria is associated with long-term cognitive impairment in children
  • 2) identification of immunologic factors that increase risk of severe malaria and cognitive impairment after severe malaria
  • 3) determination of geographic and immunologic factors that affect risk of malaria in areas of unstable malaria transmission
  • 4) the first studies to show that hydroxyurea treatment is safe and effective for children with sickle cell anemia who live in malaria endemic areas

Dr. John is an active clinician, specializing in pediatric infectious diseases and tropical medicine.


  • Malaria immunology and epidemiology, neurodevelopmental consequences of infection, severe malaria pathogenesis, severe malarial anemia and cerebral malaria, micronutrient deficiency and risk of malaria and other infections, malaria and other infections in children with sickle cell anemia.

Clinical Interests

  • Pediatric infectious disease; malaria diagnosis and treatment.

The lab of Chandy John, MD focus of research is on malaria, one of the leading causes of death and long-term morbidity in children under five years of age worldwide. Studies focus on malaria pathogenesis, immunology and epidemiology; the relationships between infection, nutrition and neurodevelopment; and infections in children with sickle cell anemia.

Infectious Diseases and Immunology, Infectious Diseases and Immunology, Pediatrics, Pediatrics, Immunology, Microbiology
MS, Case Western Reserve University, Epidemiology, 2001
MD, University of Michigan, 1988
BS, University of Michigan, 1986