Expertise

Some of our current projects in the laboratory include:

  • Human RBC (Ca+Mg)-ATPase and (Na+K)-ATPase preparation and isolation
  • Whole cell (passive) and vesicular (active) calcium transport studies
  • Effects of reversible and irreversible drug action on plasma membrane ATPase transport systems
  • Calcium ATPase active site modification with specific covalent amino acid ligands
  • Lipid modification of calcium homeostatic mechanisms in atherosclerosis
  • Effects of lipid peroxidation products on passive and active calcium transport
Molecular Pharmacology
Calcium Transport and Ion-motive ATPases
Human Erythrocyte Models
Endothelial and Neuronal Cell Cultures
Arteriosclerosis/Atherosclerosis
Enzymology
Lipoproteins and Lipid Metabolism
Mechanisms of Drug Action
Membrane Structure/Function
Membranes
Metabolism, Lipid; 4-hydroxynonenal; HNE
Molecular Probes
Pathogenesis
Pathophysiology
Pharmacology of Gamma-hydoxybutyrate, GHB Molecular Pharmacology
Calcium Transport and Ion-motive ATPases
Human Erythrocyte Models
Endothelial and Neuronal Cell Cultures
Arteriosclerosis/Atherosclerosis
Enzymology
Lipoproteins and Lipid Metabolism
Mechanisms of Drug Action
Membrane Structure/Function
Membranes
Metabolism, Lipid; 4-hydroxynonenal; HNE
Molecular Probes
Pathogenesis
Pathophysiology
Pharmacology of Gamma-hydoxybutyrate, GHB
Calcium Transport/ Homeostasis, Endothelial Function/dysfunction, GHB, Intracellular Calcium Homeostasis, NCB-20 Cell Cultures, Red Cell/ Erythrocyte Transport
Past Affiliations

Professor, Department of Pharmacology and Toxicology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Assistant Professor, Pharmacology & Toxicology
1982 - 1987

Graduate Student, Department of Pharmacology, School of Medicine, University of Washington (past)
1975 - 1980

Research Assistant, Department of Pharmacology, School of Medicine, University of Washington (past)
1975 - 1980

Research Technologist, Department of Pharmacology, School of Medicine, University of Washington (past)
1970 - 1975

Associate Professor, Pharmacology and Toxicology
1987 - 2001

Postdoctoral Fellow, Endocrinology, Department of Medicine, School of Medicine, University of Washington (past)
1980 - 1982

Research Technician, Pharmacology Institute, University of Bern (past)
1965 - 1967

Research Technologist, Radiation Biology & Biophysics, University of Rochester (past)
1967 - 1970

Professor, Pharmacology and Toxicology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Degrees
PhD, University of Washington, Pharmacology, 1980
PhD
Keywords
blood diseases arteriosclerosis immunological & bioassay methods cell components enzymes lipoproteins membranes pathology
Languages
English, French, German, Schwyzerdütsch