Research Interests:
- Stem Cell Engineering
- Cell Aging
- Cancer Cell Migration
- Microfluidics
- Vascular Tissue Engineering
Keywords:
- Stem Cell Engineering, Cell Aging, Cancer Cell Migration, Microfluidics, Vascular Tissue Engineering
Our research explores the use of engineering biophysics, cell and molecular biology and biochemistry to address critical issues in aging, cardiovascular diseases and cancer metastasis. Our key contributions are: 1) the development of a method to reverse stem cell aging for vascular rejuvenation; 2) the discovery of intracellular mechanisms regulating cell mechanosensing in confinement; 3) the development of a reporter-based system for quantifying gene and pathway activation.
We are particularly interested in exploring how biochemical and biophysical cues affect fundamental cellular processes such as migration, differentiation and gene expression in order to develop therapeutic interventions against the initiation and progression of cardiovascular diseases, cellular/organismal aging and cancer.
