Expertise

Dr. Angela Calderón’s primary research interests are in six areas:

  • Biomedical applications of mass spectrometry in the discovery and development of bioactive natural products from plants for tuberculosis and tropical diseases particularly malaria.

    The developed in-house LC-MS based biological assays are available to identify inhibitors of key metabolic enzyme (shikimate kinase) of Mycobacterium tuberculosis and inhibitors of oxidative stress related enzymes (thioredoxin and glutathione reductases) in Plasmodium falciparum.

    LC-MS based structure elucidation of bioactive natural products.

    Determination of purity of bioactive natural products using LC-MS.

  • Quality, efficacy and safety of botanical dietary supplements.
  • Botanical-drug interactions
  • Development of LC-MS based analytical methods for the identification and quantitation of bioactive or marker/standard compounds and potentially toxic compounds in botanical dietary supplements.
  • qNMR based quantitative analysis of natural products in plant material and botanical dietary supplements.
  • In vitro assessment of stability, metabolism and bioavailability of bioactive natural products and synthetic compounds using LC-MS.
  • LC-MS based metabolomic studies of promising medicinal and edible plant species and biological fluids.
  • Identification and quantitative analysis of proteins and peptides using LC-MS.
Communities
Pharmacy
Degrees
PhD, University of Lausanne, Switzerland, Pharmacognosy, 2002
MS, University of Illinois at Chicago, Pharmacognosy , 1997
BS, University of Panama, Republic of Panama, Pharmacy, 1990
Keywords
infectious diseases proteomics mass spectrometry liquid chromatography natural products research natural products chemistry natural products biology natural products drug discovery botanical dietary supplements research pharmacognosy metabolomics cancer plant, marine, soil bacterial and fungal metabolites botanical-drug interactions
Languages
English, French, Spanish
Honors

Scholarship, Fulbright, 1994-1997

Associations
American Society of Pharmacognosy
American Society for Mass Spectrometry