My research interests relate to the technical hurdles associated with creating transmitochondrial research animals (i.e., animals harboring engineered mutations in the mitochondrial genome) and gene therapy approaches for treating human diseases of the mtDNA. Another area of research uses rodent models of mitochondrial complex I inhibition for testing proprietary carnitinoid antioxidants for potential therapeutic use in human mitochondrial dysfunction and in neurodegenerative diseases such as Parkinson’s and Alzheimer’s.
His work focused on isolation and peptide sequencing of a novel cell adhesion molecule present on reactive astrocytes that plays an important role in scar formation after CNS injury.
