My laboratory is focused on targeting the proteasome for the treatment of cancer.

We are focusing on acute lymphoblastic leukemia (ALL) and triple-negative breast cancer (TNBC) because cell lines derived from these cancers are as sensitive to bortezomib as multipel myeloma cells. We are pursuing several projects:

  • Nanoparticle formulations of proteasome inhibitors to solid tumors
  • Immunoproteasome inhibitors for the treatment of hematologic malignancies
  • Mechanism of recovery of proteasome activity after treatments with inhibitors
  • Mechanistic basis of sensitivity of non-myeloma cells to proteasome inhibitors
  • Novel proteasome inhibitors
PhD, Moscow State University, Russia, 1995
MS, Moscow State University, Russia, Chemistry, 1991