His research agenda focuses on understanding the molecular, cellular, and physiological adaptations that occur in different tissues, including skeletal muscle, cardiac muscle, adipose tissue, liver, etc. He examines the tissues during periods of different metabolic loads, such as exercise, inactivity, reproduction, lactation, etc. Specifically, he focuses on mitochondria because of their key role in bioenergetics and cellular metabolism. Mitochondria produce ATP, or energy, through the Krebs cycle. Kavazis studies the mitochondrial adaptations that occur during these various metabolic states.