Tumor pathobiology and immunology; characterization of tumor antigens associated with spontaneous cancer in animals; application of monoclonal antibodies to immunodiagnosis.
The major efforts of my research group are focused on tumor-associated antigens (TAA) in canine cancer. We have generated a number of monoclonal antibodies (MAbs) which recognize TAA expressed by selected tumor types. Ongoing projects involve characterization of TAA, modulation of antigenic expression by biological response modifiers, and antibody-targeted delivery of therapeutic agents. Resource development is a continuing effort of our group with regard to establishment of tumor cell lines (about 30 established to date), generation of MAbs to TAA, and maintaining a bank of serum samples from cancer patients.
