My laboratory investigates the regulatory mechanisms that control the expression and function of genes that control a cell's ability to proliferate. We are applying the knowledge gained from these investigations to better understand the mechanisms by which cancer cells evade the normal restrictions on proliferation that limit the growth of normal cells. These investigations have allowed us to design strategies for the inhibition of cancer cell proliferation through direct suppression of oncogene expression, induction of tumor suppressor gene expression and through gene therapy and modification of the immune response by recombinant autologous hybrid-dendritic cell fusion vaccine development.

Our goal is to employ knowledge of cancer genetics and immunity to develop better therapies for dogs with cancer and through this effort to translate successful therapies for use in human patients.

PhD, University of Toronto, Canada, Zoology, 1982
BS, McMaster University, Canada, Biology , 1977