My primary research interest centers on the bacterial pathogens of farm-raised channel catfish including Edwardsiella ictaluri, Flavobacterium columnare and Aeromonas hydrophila. We have defined various aspects of the pathogenesis of enteric septicemia of catfish and characterized various components of the outer membrane of E. ictaluri. In addition, research in my lab has partially characterized the metalloprotease(s) of F. columnare. These metalloproteases are believed to play important roles in the pathogenesis of this disease in catfish and a variety of other freshwater fish species. We are also investigating the pathogenesis and pathology of an emerging virulent A. hydrophila that is causing significant morbidity and mortality in the catfish industry of western Alabama and eastern Mississippi.