Expertise

Activation of the receptor for advanced glycation endproducts (RAGE) is believed to be critically involved in diabetic complications, neurodegerative disorders, and several cancers by supporting tissue inflammation. RAGE can be activated by several structurally unrelated ligands including S100 proteins, amyloid forming peptides, and advanced glycation endproducts. We are working on understanding the ligand binding properties of RAGE using biophysical and biochemical methods. We are also interested in discovering and developing small molecules and peptides that can modulate RAGE activation.

Communities
Molecular Biology, Pharmacy
Degrees
PhD, Swiss Federal Institute of Technology, Zurich, Biochemistry, 1998
MS, Technische Universit├Ąt Braunschweig, Germany, Chemistry, 1994
Keywords
pharmacy