For nearly 40 years, Dr. Reynolds’ research program has focused on improving both fertility (the ability to conceive and to establish a pregnancy) and pregnancy outcomes (i.e., healthy offspring) in livestock. These problems have major scientific, socioeconomic, and health implications for humans as well.
Dr. Reynolds and collaborators in the U.S., Australia, Europe, and South America helped establish that placental (uterine and umbilical) blood flows are key to normal placental function (i.e., transport capacity) throughout gestation. Subsequently, they were the first to show that the placenta produces angiogenic factors, which drive its dramatic vascular development. Recognizing that placental growth also is critical, they were among the first to develop methods to evaluate the rate of cell turnover (cell proliferation and apoptosis) of tissues in vivo. More recently, Dr. Reynolds and co-workers have shown that placental vascular development and function are key mediators by which maternal stressors such as malnutrition, environmental factors, age, etc., affect pre- and postnatal well-being, and were among the first to recognize and investigate the potential impact of ‘developmental programming’ in livestock. They also have shown profound effects of assisted reproductive technologies such as in vitro fertilization on placental vascular development very early in pregnancy. They currently are investigating therapeutic and management strategies to improve fertility and pregnancy outcomes, and also the role of the fetal and maternal steroid metabolome in the processes of fetal organ maturation and birth.
Dr. Reynolds has been PI or Co-I on 36 federal grants from NIH, NSF, and USDA (approx. $12.6 million total). He has published more than 200 book chapters and journal articles including 26 invited reviews (see My Bibliography at NCBI). His publications have been cited more than 9,300 times (h-index 52). He has received the American Society of Animal Science’s Animal Growth and Development Award, the ASAS’s Animal Physiology and Endocrinology Award, the Eugene R. Dahl Excellence in Research Award at NDSU, and the 51st NDSU Faculty Lectureship.
Dr. Reynolds has taught more than 20 different undergraduate and graduate courses in cell biology, endocrinology, growth biology, and reproductive biology. He has mentored more than 35 undergraduate research interns, 13 graduate students, and 30 postdoctoral fellows, visiting scientists and junior faculty. He also is Co-Director of the Frontiers in Reproduction advanced summer course at the Marine Biological Lab in Woods Hole, MA.
Dr. Reynolds has co-organized or spoken at 45 national/international symposia and held 15 Visiting Professorships and Keynote Speakerships throughout the world. Since 1986, he has served on or chaired more than 50 federal grant-review panels for NIH and USDA. He also is involved with a national effort promoting farm animals as dual-use models for agricultural and biomedical research. From 2005 to 2008, Dr. Reynolds served as Editor-in-Chief of the Journal of Animal Science, the world’s top-ranked Animal Science journal. He was named ‘University Distinguished Professor of Animal Sciences’ at NDSU in 2008.
Dr. Reynolds is a founding Director of the Center for Nutrition and Pregnancy at NDSU, and is involved with national/international efforts to highlight the importance of funding for livestock research, which is critical to food security and agricultural sustainability